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Dnajb14 DnaJ heat shock protein family (Hsp40) member B14 [ Mus musculus (house mouse) ]

Gene ID: 70604, updated on 8-Dec-2022

Summary

Official Symbol
Dnajb14provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member B14provided by MGI
Primary source
MGI:MGI:1917854
See related
Ensembl:ENSMUSG00000074212 AllianceGenome:MGI:1917854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730496F10Rik
Summary
Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DNAJB14 (DnaJ heat shock protein family (Hsp40) member B14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 8.5), cerebellum adult (RPKM 6.3) and 27 other tissues See more
Orthologs
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Genomic context

See Dnajb14 in Genome Data Viewer
Location:
3; 3 G3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (137572801..137619350)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (137867675..137916563)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 43403 Neighboring gene H2A.Z variant histone 1 Neighboring gene predicted gene, 40155 Neighboring gene protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) pseudogene Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 Neighboring gene dual adaptor for phosphotyrosine and 3-phosphoinositides 1 Neighboring gene predicted gene, 19708

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to misfolded protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily B member 14
Names
DnaJ (Hsp40) homolog, subfamily B, member 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033155.1NP_001028327.1  dnaJ homolog subfamily B member 14

    See identical proteins and their annotated locations for NP_001028327.1

    Status: VALIDATED

    Source sequence(s)
    AC125154, AC146607
    Consensus CDS
    CCDS51077.1
    UniProtKB/Swiss-Prot
    Q149L6, Q3UTE5
    Related
    ENSMUSP00000087641.6, ENSMUST00000090178.10
    Conserved Domains (3) summary
    COG0484
    Location:107214
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:108169
    DnaJ; DnaJ domain
    pfam09320
    Location:271371
    DUF1977; Domain of unknown function (DUF1977)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    137572801..137619350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163304.1XP_036019197.1  dnaJ homolog subfamily B member 14 isoform X2

    Conserved Domains (1) summary
    COG0484
    Location:107214
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
  2. XM_006502056.3XP_006502119.1  dnaJ homolog subfamily B member 14 isoform X3

    Conserved Domains (2) summary
    COG0484
    Location:40147
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam09320
    Location:204304
    DUF1977; Domain of unknown function (DUF1977)
  3. XM_006502055.3XP_006502118.1  dnaJ homolog subfamily B member 14 isoform X1

    UniProtKB/Swiss-Prot
    Q149L6
    Conserved Domains (2) summary
    COG0484
    Location:57164
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam09320
    Location:221321
    DUF1977; Domain of unknown function (DUF1977)