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WDR76 WD repeat domain 76 [ Homo sapiens (human) ]

Gene ID: 79968, updated on 23-Nov-2021

Summary

Official Symbol
WDR76provided by HGNC
Official Full Name
WD repeat domain 76provided by HGNC
Primary source
HGNC:HGNC:25773
See related
Ensembl:ENSG00000092470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDW14
Expression
Broad expression in lymph node (RPKM 6.6), bone marrow (RPKM 3.7) and 23 other tissues See more
Orthologs
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Genomic context

See WDR76 in Genome Data Viewer
Location:
15q15.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (43826977..43868419)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (44119200..44160610)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SERF2-C15orf63 readthrough Neighboring gene microfibril associated protein 1 Neighboring gene huntingtin interacting protein K Neighboring gene VISTA enhancer hs1881 Neighboring gene FERM domain containing 5 Neighboring gene peptidylprolyl cis/trans isomerase, NIMA-interacting 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12973

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in heterochromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167941.2NP_001161413.1  WD repeat-containing protein 76 isoform 2

    See identical proteins and their annotated locations for NP_001161413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AA743653, AC023356, AK023035, BC025247, BC051855, BX374706
    Consensus CDS
    CCDS53938.1
    UniProtKB/Swiss-Prot
    Q9H967
    UniProtKB/TrEMBL
    A0A0C4DFX7
    Conserved Domains (2) summary
    sd00039
    Location:252294
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:249460
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_024908.4NP_079184.2  WD repeat-containing protein 76 isoform 1

    See identical proteins and their annotated locations for NP_079184.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA743653, AC023356, AK023035, BC025247, DA439086
    Consensus CDS
    CCDS10106.1
    UniProtKB/Swiss-Prot
    Q9H967
    Related
    ENSP00000263795.6, ENST00000263795.11
    Conserved Domains (3) summary
    COG2319
    Location:242541
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:316358
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:313524
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    43826977..43868419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254680.3XP_005254737.1  WD repeat-containing protein 76 isoform X1

    See identical proteins and their annotated locations for XP_005254737.1

    UniProtKB/Swiss-Prot
    Q9H967
    UniProtKB/TrEMBL
    A0A0C4DFX7
    Related
    ENSP00000370645.2, ENST00000381246.6
    Conserved Domains (2) summary
    sd00039
    Location:252294
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:249460
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001751398.2 RNA Sequence

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