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JADE1 jade family PHD finger 1 [ Homo sapiens (human) ]

Gene ID: 79960, updated on 25-Nov-2025
Official Symbol
JADE1provided by HGNC
Official Full Name
jade family PHD finger 1provided by HGNC
Primary source
HGNC:HGNC:30027
See related
Ensembl:ENSG00000077684 MIM:610514; AllianceGenome:HGNC:30027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHF17
Summary
Enables transcription coactivator activity. Contributes to histone acetyltransferase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in several cellular components, including cytosol; microtubule organizing center; and nuclear speck. Part of histone acetyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in thyroid (RPKM 13.1), ovary (RPKM 12.4) and 25 other tissues See more
Orthologs
NEW
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See JADE1 in Genome Data Viewer
Location:
4q28.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (128809700..128875224)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (132113886..132179423)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (129730855..129796379)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3140 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129535873-129536374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129536375-129536874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:129560764-129561264 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129565349-129565848 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:129569028-129569766 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129573717-129574216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21893 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:129603876-129604400 Neighboring gene Sharpr-MPRA regulatory region 780 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129605286-129606025 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:129606954-129608153 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129613233-129613734 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74071 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_74072 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129654815-129655316 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:129655317-129655816 Neighboring gene small nucleolar RNA U13 Neighboring gene NANOG hESC enhancer GRCh37_chr4:129697052-129697573 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129723780-129724699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15690 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129734111-129734692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:129734693-129735274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21898 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:129752609-129753288 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:129753289-129753968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:129756920-129757462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21901 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21902 Neighboring gene chromosome 4 open reading frame 33 Neighboring gene CDRT15 pseudogene 11

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • FLJ22479, KIAA1807

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 
part_of histone acetyltransferase complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein Jade-1
Names
PHD finger protein 17
PHD protein Jade-1
gene for apoptosis and differentiation in epithelia
jade family PHD finger protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287437.2NP_001274366.1  protein Jade-1 isoform 3

    See identical proteins and their annotated locations for NP_001274366.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC093783, AK027620, AK127326, BI463062
    Consensus CDS
    CCDS75191.1
    UniProtKB/TrEMBL
    B4E2E2
    Related
    ENSP00000388015.2, ENST00000452328.6
    Conserved Domains (2) summary
    cd15671
    Location:246356
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
    cl26518
    Location:88517
    EPL1; Enhancer of polycomb-like
  2. NM_001287439.2NP_001274368.1  protein Jade-1 isoform 1

    See identical proteins and their annotated locations for NP_001274368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AC093783, AK304235, BN000287, DC308588
    Consensus CDS
    CCDS34062.1
    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2
    Related
    ENSP00000425730.1, ENST00000512960.5
    Conserved Domains (2) summary
    COG5141
    Location:99529
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:258368
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  3. NM_001287440.2NP_001274369.1  protein Jade-1 isoform 1

    See identical proteins and their annotated locations for NP_001274369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AC093783, BN000287, DA478923
    Consensus CDS
    CCDS34062.1
    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2
    Conserved Domains (2) summary
    COG5141
    Location:99529
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:258368
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  4. NM_001287441.2NP_001274370.1  protein Jade-1 isoform 2

    See identical proteins and their annotated locations for NP_001274370.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks two exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AF520952, AK074986, BC032376, BX107708, DA714593
    Consensus CDS
    CCDS47134.1
    UniProtKB/Swiss-Prot
    Q6IE81
    Related
    ENSP00000404211.2, ENST00000413543.6
    Conserved Domains (2) summary
    cd15704
    Location:255372
    ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
    cl26518
    Location:99503
    EPL1; Enhancer of polycomb-like
  5. NM_001287442.1NP_001274371.1  protein Jade-1 isoform 1

    See identical proteins and their annotated locations for NP_001274371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AC093783, BN000287, DA714593, DB293142
    Consensus CDS
    CCDS34062.1
    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2
    Related
    ENSP00000483219.1, ENST00000610919.4
    Conserved Domains (2) summary
    COG5141
    Location:99529
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:258368
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  6. NM_001287443.1NP_001274372.1  protein Jade-1 isoform 1

    See identical proteins and their annotated locations for NP_001274372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, compared to variant 1. Variants 1, 4, 5, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AC093783, AC108024, BN000287, DB085413
    Consensus CDS
    CCDS34062.1
    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2
    Related
    ENSP00000482212.1, ENST00000611140.4
    Conserved Domains (2) summary
    COG5141
    Location:99529
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:258368
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  7. NM_024900.5NP_079176.2  protein Jade-1 isoform 2

    See identical proteins and their annotated locations for NP_079176.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Variants 2 and 6 encode the same isoform.
    Source sequence(s)
    AF520952, AK027620, AK074986, BI463062, BX107708
    Consensus CDS
    CCDS47134.1
    UniProtKB/Swiss-Prot
    Q6IE81
    Related
    ENSP00000423737.1, ENST00000511647.5
    Conserved Domains (2) summary
    cd15704
    Location:255372
    ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
    cl26518
    Location:99503
    EPL1; Enhancer of polycomb-like
  8. NM_199320.4NP_955352.1  protein Jade-1 isoform 1

    See identical proteins and their annotated locations for NP_955352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, 5, 7, and 8 encode the same isoform.
    Source sequence(s)
    AC093783, AK027620, BI463062, BN000287
    Consensus CDS
    CCDS34062.1
    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2
    Related
    ENSP00000226319.6, ENST00000226319.11
    Conserved Domains (2) summary
    COG5141
    Location:99529
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:258368
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    128809700..128875224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008626.3XP_016864115.1  protein Jade-1 isoform X4

    Conserved Domains (2) summary
    cd15704
    Location:255372
    ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
    cl26518
    Location:99502
    EPL1; Enhancer of polycomb-like
  2. XM_024454219.2XP_024309987.1  protein Jade-1 isoform X3

    UniProtKB/TrEMBL
    B4E2E2
    Conserved Domains (2) summary
    cd15671
    Location:271381
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
    cl26518
    Location:112542
    EPL1; Enhancer of polycomb-like
  3. XM_017008627.2XP_016864116.1  protein Jade-1 isoform X4

    Conserved Domains (2) summary
    cd15704
    Location:255372
    ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
    cl26518
    Location:99502
    EPL1; Enhancer of polycomb-like
  4. XM_024454217.2XP_024309985.1  protein Jade-1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2
    Related
    ENSP00000557662.1, ENST00000887603.1
    Conserved Domains (2) summary
    COG5141
    Location:99529
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:258368
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  5. XM_024454221.2XP_024309989.1  protein Jade-1 isoform X4

    Conserved Domains (2) summary
    cd15704
    Location:255372
    ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
    cl26518
    Location:99502
    EPL1; Enhancer of polycomb-like
  6. XM_024454218.2XP_024309986.1  protein Jade-1 isoform X2

    UniProtKB/TrEMBL
    B4E2E2
    Related
    ENSP00000617651.1, ENST00000947592.1
    Conserved Domains (2) summary
    cd15704
    Location:270387
    ePHD_JADE1; Extended PHD finger found in protein Jade-1 and similar proteins
    cl26518
    Location:114544
    EPL1; Enhancer of polycomb-like
  7. XM_047416183.1XP_047272139.1  protein Jade-1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2
    Related
    ENSP00000557664.1, ENST00000887605.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    132113886..132179423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350862.1XP_054206837.1  protein Jade-1 isoform X4

  2. XM_054350859.1XP_054206834.1  protein Jade-1 isoform X3

    UniProtKB/TrEMBL
    B4E2E2
  3. XM_054350863.1XP_054206838.1  protein Jade-1 isoform X4

  4. XM_054350857.1XP_054206832.1  protein Jade-1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2
  5. XM_054350861.1XP_054206836.1  protein Jade-1 isoform X4

  6. XM_054350858.1XP_054206833.1  protein Jade-1 isoform X2

    UniProtKB/TrEMBL
    B4E2E2
  7. XM_054350860.1XP_054206835.1  protein Jade-1 isoform X1

    UniProtKB/Swiss-Prot
    D3DNY0, D3DNY1, Q4W5D5, Q6IE81, Q6ZSL7, Q8NC41, Q96JL8, Q96SQ1, Q9H692
    UniProtKB/TrEMBL
    B4E2E2