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Jade1 jade family PHD finger 1 [ Mus musculus (house mouse) ]

Gene ID: 269424, updated on 13-Oct-2022

Summary

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Official Symbol
Jade1provided by MGI
Official Full Name
jade family PHD finger 1provided by MGI
Primary source
MGI:MGI:1925835
See related
Ensembl:ENSMUSG00000025764 AllianceGenome:MGI:1925835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phf17; mKIAA1807; D530048A03Rik
Summary
Predicted to enable transcription coactivator activity. Predicted to be involved in histone acetylation and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in cytosol and nucleus. Is expressed in several structures, including early conceptus; embryo ectoderm; genitourinary system; head somite; and primitive streak. Orthologous to human JADE1 (jade family PHD finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 17.9), bladder adult (RPKM 5.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Jade1 in Genome Data Viewer
Location:
3; 3 B
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (41510169..41571299)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (41555734..41616864)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2400006E01 gene Neighboring gene pluripotency associated transcript 4 Neighboring gene uncharacterized LOC118568628 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene DNA segment, Chr 3, ERATO Doi 751, expressed

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. Wan G, et al. EMBO J, 2013 Oct 30. PMID 24097061, Free PMC Article
  2. Cell cycle-dependent chromatin shuttling of HBO1-JADE1 histone acetyl transferase (HAT) complex. Siriwardana NS, et al. Cell Cycle, 2014. PMID 24739512, Free PMC Article
  3. The von Hippel-Lindau tumor suppressor stabilizes novel plant homeodomain protein Jade-1. Zhou MI, et al. J Biol Chem, 2002 Oct 18. PMID 12169691
  4. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Foy RL, et al. Hum Mol Genet, 2012 Dec 15. PMID 23001567, Free PMC Article
  5. Noncanonical imprinting sustains embryonic development and restrains placental overgrowth. Matoba S, et al. Genes Dev, 2022 Apr 1. PMID 35483741, Free PMC Article

See all (38) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
    Title: Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression.
  2. lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis.
    Title: A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation.
  3. exhibits a regulated expression during embryogenesis and localizes to the nucleus and/or cytoplasm of different cell types
    Title: Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histone H4-K12 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone H4-K5 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone H4-K8 acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in histone modification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein Jade-1
Names
Jade1 PHD finger protein
PHD finger protein 17
jade family PHD finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130184.1 → NP_001123656.1  protein Jade-1

    See identical proteins and their annotated locations for NP_001123656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AV515494, BN000281, BY060282
    Consensus CDS
    CCDS17331.1
    UniProtKB/Swiss-Prot
    Q6ZPI0, Q8R362
    Related
    ENSMUSP00000026865.9, ENSMUST00000026865.15
    Conserved Domains (2) summary
    COG5141
    Location:100 → 528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259 → 369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

  2. NM_001130185.1 → NP_001123657.1  protein Jade-1

    See identical proteins and their annotated locations for NP_001123657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AV515494, BN000281, BY146568
    Consensus CDS
    CCDS17331.1
    UniProtKB/Swiss-Prot
    Q6ZPI0, Q8R362
    Related
    ENSMUSP00000127113.2, ENSMUST00000170711.8
    Conserved Domains (2) summary
    COG5141
    Location:100 → 528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259 → 369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

  3. NM_001130186.1 → NP_001123658.1  protein Jade-1

    See identical proteins and their annotated locations for NP_001123658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AV515494, BN000281, CD563805
    Consensus CDS
    CCDS17331.1
    UniProtKB/Swiss-Prot
    Q6ZPI0, Q8R362
    Related
    ENSMUSP00000131441.2, ENSMUST00000168086.7
    Conserved Domains (2) summary
    COG5141
    Location:100 → 528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259 → 369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

  4. NM_172303.4 → NP_758507.3  protein Jade-1

    See identical proteins and their annotated locations for NP_758507.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AV515494, BN000281, CJ060622
    Consensus CDS
    CCDS17331.1
    UniProtKB/Swiss-Prot
    Q6ZPI0, Q8R362
    Related
    ENSMUSP00000128152.2, ENSMUST00000163764.8
    Conserved Domains (2) summary
    COG5141
    Location:100 → 528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259 → 369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    41510169..41571299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252630.1 → XP_030108490.1  protein Jade-1 isoform X1

    UniProtKB/Swiss-Prot
    Q8R362
    Conserved Domains (2) summary
    COG5141
    Location:100 → 528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259 → 369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

  2. XM_030252631.2 → XP_030108491.1  protein Jade-1 isoform X1

    UniProtKB/Swiss-Prot
    Q8R362
    Conserved Domains (2) summary
    COG5141
    Location:100 → 528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259 → 369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

  3. XM_006500784.4 → XP_006500847.1  protein Jade-1 isoform X2

    Conserved Domains (2) summary
    COG5141
    Location:115 → 543
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:274 → 384
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZPI0.2 GenPept UniProtKB/Swiss-Prot:Q6ZPI0

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