U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Jade1 jade family PHD finger 1 [ Mus musculus (house mouse) ]

Gene ID: 269424, updated on 11-Jun-2025
Official Symbol
Jade1provided by MGI
Official Full Name
jade family PHD finger 1provided by MGI
Primary source
MGI:MGI:1925835
See related
Ensembl:ENSMUSG00000025764 AllianceGenome:MGI:1925835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Phf17; mKIAA1807; D530048A03Rik
Summary
Predicted to enable transcription coactivator activity. Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; regulation of cell growth; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Predicted to be located in several cellular components, including microtubule organizing center; nuclear speck; and plasma membrane. Predicted to be part of histone acetyltransferase complex. Is expressed in several structures, including early conceptus; embryo ectoderm; genitourinary system; head somite; and primitive streak. Orthologous to human JADE1 (jade family PHD finger 1). [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 17.9), bladder adult (RPKM 5.1) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table
See Jade1 in Genome Data Viewer
Location:
3 B; 3 19.88 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (41510169..41571299)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (41555734..41616864)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07488 Neighboring gene RIKEN cDNA 2400006E01 gene Neighboring gene pluripotency associated transcript 4 Neighboring gene STARR-seq mESC enhancer starr_07494 Neighboring gene uncharacterized LOC118568628 Neighboring gene sodium channel and clathrin linker 1 Neighboring gene STARR-seq mESC enhancer starr_07506 Neighboring gene STARR-seq mESC enhancer starr_07507 Neighboring gene STARR-seq mESC enhancer starr_07508 Neighboring gene STARR-seq mESC enhancer starr_07509 Neighboring gene STARR-positive B cell enhancer mm9_chr3:41546357-41546658 Neighboring gene DNA segment, Chr 3, ERATO Doi 751, expressed Neighboring gene STARR-seq mESC enhancer starr_07510

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to histone H3K14 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone H3K14 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone H3K14 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to histone H4K12 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone H4K12 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone H4K12 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT contributes_to histone H4K16 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to histone H4K5 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone H4K5 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone H4K5 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to histone H4K8 acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to histone H4K8 acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to histone H4K8 acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
 
part_of histone acetyltransferase complex ISO
Inferred from Sequence Orthology
more info
 
part_of histone acetyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein Jade-1
Names
Jade1 PHD finger protein
PHD finger protein 17
jade family PHD finger protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130184.1NP_001123656.1  protein Jade-1

    See identical proteins and their annotated locations for NP_001123656.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AV515494, BN000281, BY060282
    Consensus CDS
    CCDS17331.1
    UniProtKB/Swiss-Prot
    Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
    Related
    ENSMUSP00000026865.9, ENSMUST00000026865.15
    Conserved Domains (2) summary
    COG5141
    Location:100528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  2. NM_001130185.1NP_001123657.1  protein Jade-1

    See identical proteins and their annotated locations for NP_001123657.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AV515494, BN000281, BY146568
    Consensus CDS
    CCDS17331.1
    UniProtKB/Swiss-Prot
    Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
    Related
    ENSMUSP00000127113.2, ENSMUST00000170711.8
    Conserved Domains (2) summary
    COG5141
    Location:100528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  3. NM_001130186.1NP_001123658.1  protein Jade-1

    See identical proteins and their annotated locations for NP_001123658.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AV515494, BN000281, CD563805
    Consensus CDS
    CCDS17331.1
    UniProtKB/Swiss-Prot
    Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
    Related
    ENSMUSP00000131441.2, ENSMUST00000168086.7
    Conserved Domains (2) summary
    COG5141
    Location:100528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  4. NM_172303.4NP_758507.3  protein Jade-1

    See identical proteins and their annotated locations for NP_758507.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AV515494, BN000281, CJ060622
    Consensus CDS
    CCDS17331.1
    UniProtKB/Swiss-Prot
    Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
    Related
    ENSMUSP00000128152.2, ENSMUST00000163764.8
    Conserved Domains (2) summary
    COG5141
    Location:100528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    41510169..41571299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252630.1XP_030108490.1  protein Jade-1 isoform X1

    UniProtKB/Swiss-Prot
    Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
    Conserved Domains (2) summary
    COG5141
    Location:100528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  2. XM_030252631.2XP_030108491.1  protein Jade-1 isoform X1

    UniProtKB/Swiss-Prot
    Q6IE84, Q6ZPI0, Q8C7S6, Q8CFM2, Q8R362
    Conserved Domains (2) summary
    COG5141
    Location:100528
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:259369
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins
  3. XM_006500784.4XP_006500847.1  protein Jade-1 isoform X2

    Conserved Domains (2) summary
    COG5141
    Location:115543
    COG5141; PHD zinc finger-containing protein [General function prediction only]
    cd15671
    Location:274384
    ePHD_JADE; Extended PHD finger found in protein Jade-1, Jade-2, Jade-3 and similar proteins