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CEP76 centrosomal protein 76 [ Homo sapiens (human) ]

Gene ID: 79959, updated on 8-Jul-2021

Summary

Official Symbol
CEP76provided by HGNC
Official Full Name
centrosomal protein 76provided by HGNC
Primary source
HGNC:HGNC:25727
See related
Ensembl:ENSG00000101624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C18orf9; HsT1705
Summary
This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Broad expression in testis (RPKM 7.3), esophagus (RPKM 1.7) and 23 other tissues See more
Orthologs
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Genomic context

See CEP76 in Genome Data Viewer
Location:
18p11.21
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (12661956..12702777, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12661955..12702776, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371998 Neighboring gene high mobility group box 3 pseudogene 28 Neighboring gene spire type actin nucleation factor 1 Neighboring gene proteasome assembly chaperone 2 Neighboring gene long intergenic non-protein coding RNA 1882 Neighboring gene protein tyrosine phosphatase non-receptor type 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12542

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centrosomal protein of 76 kDa
Names
centrosomal protein 76kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271989.2NP_001258918.1  centrosomal protein of 76 kDa isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform (b) which is shorter than isoform a.
    Source sequence(s)
    AK298223, AK303117, AP005482, BC026307, DA476378
    Consensus CDS
    CCDS62390.1
    UniProtKB/Swiss-Prot
    Q8TAP6
    UniProtKB/TrEMBL
    B4DP81
    Related
    ENSP00000403074.1, ENST00000423709.6
    Conserved Domains (2) summary
    pfam01841
    Location:290336
    Transglut_core; Transglutaminase-like superfamily
    pfam15627
    Location:96183
    CEP76-C2; CEP76 C2 domain
  2. NM_024899.4NP_079175.2  centrosomal protein of 76 kDa isoform a

    See identical proteins and their annotated locations for NP_079175.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK298223, AP005482, BC026307, DA476378
    Consensus CDS
    CCDS11861.1
    UniProtKB/Swiss-Prot
    Q8TAP6
    UniProtKB/TrEMBL
    B4DP81
    Related
    ENSP00000262127.2, ENST00000262127.7
    Conserved Domains (1) summary
    pfam15627
    Location:101258
    CEP76-C2; CEP76 C2 domain

RNA

  1. NR_073537.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in internal exons and has an alternate 3' exon. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK298223, AK301964, BC026307, BC033026, BX505397
    Related
    ENST00000590143.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    12661956..12702777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258149.5XP_005258206.1  centrosomal protein of 76 kDa isoform X2

    Conserved Domains (2) summary
    pfam01841
    Location:365411
    Transglut_core; Transglutaminase-like superfamily
    pfam15627
    Location:101258
    CEP76-C2; CEP76 C2 domain
  2. XM_017025981.2XP_016881470.1  centrosomal protein of 76 kDa isoform X1

  3. XM_017025984.1XP_016881473.1  centrosomal protein of 76 kDa isoform X5

  4. XM_017025983.2XP_016881472.1  centrosomal protein of 76 kDa isoform X4

  5. XM_017025982.1XP_016881471.1  centrosomal protein of 76 kDa isoform X3

  6. XM_017025985.1XP_016881474.1  centrosomal protein of 76 kDa isoform X5

  7. XM_017025987.1XP_016881476.1  centrosomal protein of 76 kDa isoform X5

  8. XM_017025986.1XP_016881475.1  centrosomal protein of 76 kDa isoform X5

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