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CEP76 centrosomal protein 76 [ Homo sapiens (human) ]

Gene ID: 79959, updated on 12-Aug-2018

Summary

Official Symbol
CEP76provided by HGNC
Official Full Name
centrosomal protein 76provided by HGNC
Primary source
HGNC:HGNC:25727
See related
Ensembl:ENSG00000101624 Vega:OTTHUMG00000131701
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C18orf9; HsT1705
Summary
This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Expression
Broad expression in testis (RPKM 7.3), esophagus (RPKM 1.7) and 23 other tissues See more
Orthologs

Genomic context

See CEP76 in Genome Data Viewer
Location:
18p11.21
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 18 NC_000018.10 (12661956..12702777, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (12661748..12702776, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371998 Neighboring gene high mobility group box 3 pseudogene 28 Neighboring gene spire type actin nucleation factor 1 Neighboring gene proteasome assembly chaperone 2 Neighboring gene long intergenic non-protein coding RNA 1882 Neighboring gene protein tyrosine phosphatase, non-receptor type 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Pathways from BioSystems

  • AURKA Activation by TPX2, organism-specific biosystem (from REACTOME)
    AURKA Activation by TPX2, organism-specific biosystemTPX2 binds to aurora kinase A (AURKA) at centrosomes and promotes its activation by facilitating AURKA active conformation and autophosphorylation of the AURKA threonine residue T288 (Bayliss et al. ...
  • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
    Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Centrosome maturation, organism-specific biosystem (from REACTOME)
    Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • G2/M Transition, organism-specific biosystem (from REACTOME)
    G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
  • Loss of Nlp from mitotic centrosomes, organism-specific biosystem (from REACTOME)
    Loss of Nlp from mitotic centrosomes, organism-specific biosystemDuring interphase, Nlp interacts with gamma-tubulin ring complexes (gamma-TuRC), and is thought to contribute to the organization of interphase microtubules (Casenghi et al.,2003). Plk1 is activated...
  • Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystem (from REACTOME)
    Loss of proteins required for interphase microtubule organization from the centrosome, organism-specific biosystemIn addition to recruiting proteins and complexes necessary for increased microtubule nucleation, centrosomal maturation involves the loss of proteins involved in interphase microtubule organization ...
  • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
    Mitotic G2-G2/M phases, organism-specific biosystem
    Mitotic G2-G2/M phases
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
    Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
  • Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystem (from REACTOME)
    Regulation of PLK1 Activity at G2/M Transition, organism-specific biosystemThe kinase activity of PLK1 is required for cell cycle progression as PLK1 phosphorylates and regulates a number of cellular proteins during mitosis. Centrosomic AURKA (Aurora A kinase), catalyticall...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12542

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centriole IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centrosomal protein of 76 kDa
Names
centrosomal protein 76kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271989.1NP_001258918.1  centrosomal protein of 76 kDa isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform (b) which is shorter than isoform a.
    Source sequence(s)
    AK298223, AK303117, BC026307, DA476378
    Consensus CDS
    CCDS62390.1
    UniProtKB/Swiss-Prot
    Q8TAP6
    UniProtKB/TrEMBL
    B4DP81
    Related
    ENSP00000403074.1, OTTHUMP00000265604, ENST00000423709.6, OTTHUMT00000453513
    Conserved Domains (2) summary
    pfam01841
    Location:290336
    Transglut_core; Transglutaminase-like superfamily
    pfam15627
    Location:96183
    CEP76-C2; CEP76 C2 domain
  2. NM_024899.3NP_079175.2  centrosomal protein of 76 kDa isoform a

    See identical proteins and their annotated locations for NP_079175.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK298223, BC026307, DA476378
    Consensus CDS
    CCDS11861.1
    UniProtKB/Swiss-Prot
    Q8TAP6
    UniProtKB/TrEMBL
    B4DP81
    Related
    ENSP00000262127.2, OTTHUMP00000162484, ENST00000262127.6, OTTHUMT00000254611
    Conserved Domains (1) summary
    pfam15627
    Location:101258
    CEP76-C2; CEP76 C2 domain

RNA

  1. NR_073537.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in internal exons and has an alternate 3' exon. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK298223, AK301964, BC026307, BC033026, BX505397
    Related
    ENST00000590143.5, OTTHUMT00000453511

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p12 Primary Assembly

    Range
    12661956..12702777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258149.5XP_005258206.1  centrosomal protein of 76 kDa isoform X2

    Conserved Domains (2) summary
    pfam01841
    Location:365411
    Transglut_core; Transglutaminase-like superfamily
    pfam15627
    Location:101258
    CEP76-C2; CEP76 C2 domain
  2. XM_017025981.2XP_016881470.1  centrosomal protein of 76 kDa isoform X1

  3. XM_017025984.1XP_016881473.1  centrosomal protein of 76 kDa isoform X5

  4. XM_017025983.2XP_016881472.1  centrosomal protein of 76 kDa isoform X4

  5. XM_017025982.1XP_016881471.1  centrosomal protein of 76 kDa isoform X3

  6. XM_017025985.1XP_016881474.1  centrosomal protein of 76 kDa isoform X5

  7. XM_017025987.1XP_016881476.1  centrosomal protein of 76 kDa isoform X5

  8. XM_017025986.1XP_016881475.1  centrosomal protein of 76 kDa isoform X5

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