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TNIP3 TNFAIP3 interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 79931, updated on 5-Aug-2022

Summary

Official Symbol
TNIP3provided by HGNC
Official Full Name
TNFAIP3 interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:19315
See related
Ensembl:ENSG00000050730 MIM:608019; AllianceGenome:HGNC:19315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIND; ABIN-3
Summary
Enables polyubiquitin modification-dependent protein binding activity. Involved in cellular response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB signaling; and toll-like receptor signaling pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in appendix (RPKM 1.2), lymph node (RPKM 0.4) and 11 other tissues See more
Orthologs
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Genomic context

See TNIP3 in Genome Data Viewer
Location:
4q27
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (121131408..121227483, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (124435731..124531810, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122052563..122148638, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 137 Neighboring gene neuron derived neurotrophic factor Neighboring gene NDNF antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6302 Neighboring gene RNA, U6 small nuclear 948, pseudogene Neighboring gene KIAA1191 pseudogene Neighboring gene pyroglutamylated RFamide peptide receptor Neighboring gene uncharacterized LOC107986309 Neighboring gene TUBB4B pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of TNFAIP3 interacting protein 3 (TNIP3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21162

General protein information

Preferred Names
TNFAIP3-interacting protein 3
Names
A20-binding inhibitor of NF-kappa-B activation 3
ABIN-3 beta
Listeria induced
TNFAIP3-interacting protein 3 beta
TNIP3 beta
listeria-induced gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128843.2NP_001122315.2  TNFAIP3-interacting protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001122315.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, and lacks an exon in the 3' coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 2) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AC105254, AK301058, DC389224
    Consensus CDS
    CCDS58925.1
    UniProtKB/Swiss-Prot
    Q96KP6
    Related
    ENSP00000427106.1, ENST00000507879.5
    Conserved Domains (2) summary
    cd09803
    Location:227313
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:173332
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  2. NM_001244764.2NP_001231693.1  TNFAIP3-interacting protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001231693.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, and lacks an exon in the 3' coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 3) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AC105254, AC108027, AK303192
    Consensus CDS
    CCDS58926.1
    UniProtKB/Swiss-Prot
    Q96KP6
    Related
    ENSP00000426613.1, ENST00000509841.1
    Conserved Domains (2) summary
    cd09803
    Location:234320
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:180339
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. NM_024873.6NP_079149.3  TNFAIP3-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_079149.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest protein (isoform 1).
    Source sequence(s)
    AC105254, AK024815, AK290409, CD367219
    Consensus CDS
    CCDS3718.1
    UniProtKB/Swiss-Prot
    Q96KP6, Q9H780
    Related
    ENSP00000057513.3, ENST00000057513.8
    Conserved Domains (2) summary
    cd09803
    Location:157243
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:103262
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    121131408..121227483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416182.1XP_047272138.1  TNFAIP3-interacting protein 3 isoform X4

  2. XM_011532257.4XP_011530559.1  TNFAIP3-interacting protein 3 isoform X3

    Conserved Domains (2) summary
    cd09803
    Location:264350
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    COG1196
    Location:140369
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  3. XM_011532256.3XP_011530558.1  TNFAIP3-interacting protein 3 isoform X1

    Conserved Domains (2) summary
    cd09803
    Location:264350
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:210369
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  4. XM_047416181.1XP_047272137.1  TNFAIP3-interacting protein 3 isoform X2

  5. XM_017008625.3XP_016864114.2  TNFAIP3-interacting protein 3 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    124435731..124531810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)