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TNIP3 TNFAIP3 interacting protein 3 [ Homo sapiens (human) ]

Gene ID: 79931, updated on 11-Sep-2019

Summary

Official Symbol
TNIP3provided by HGNC
Official Full Name
TNFAIP3 interacting protein 3provided by HGNC
Primary source
HGNC:HGNC:19315
See related
Ensembl:ENSG00000050730 MIM:608019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIND; ABIN-3
Expression
Biased expression in appendix (RPKM 1.2), lymph node (RPKM 0.4) and 11 other tissues See more
Orthologs

Genomic context

See TNIP3 in Genome Data Viewer
Location:
4q27
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (121131408..121227609, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122052563..122148624, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377400 Neighboring gene RN7SK pseudogene 137 Neighboring gene neuron derived neurotrophic factor Neighboring gene RNA, U6 small nuclear 948, pseudogene Neighboring gene KIAA1191 pseudogene Neighboring gene pyroglutamylated RFamide peptide receptor Neighboring gene uncharacterized LOC107986309 Neighboring gene tubulin beta 4B class IVb pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of TNFAIP3 interacting protein 3 (TNIP3) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Deubiquitination, organism-specific biosystem (from REACTOME)
    Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
    Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
    Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
TNFAIP3-interacting protein 3
Names
A20-binding inhibitor of NF-kappa-B activation 3
ABIN-3 beta
Listeria induced
TNFAIP3-interacting protein 3 beta
TNIP3 beta
listeria-induced gene protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128843.2NP_001122315.2  TNFAIP3-interacting protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001122315.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, and lacks an exon in the 3' coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 2) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AC105254, AK301058, DC389224
    Consensus CDS
    CCDS58925.1
    UniProtKB/Swiss-Prot
    Q96KP6
    Related
    ENSP00000427106.1, ENST00000507879.5
    Conserved Domains (2) summary
    cd09803
    Location:227313
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:173332
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  2. NM_001244764.2NP_001231693.1  TNFAIP3-interacting protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001231693.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, and lacks an exon in the 3' coding region which results in a frameshift compared to variant 1. The encoded protein (isoform 3) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AC105254, AC108027, AK303192
    Consensus CDS
    CCDS58926.1
    UniProtKB/Swiss-Prot
    Q96KP6
    Related
    ENSP00000426613.1, ENST00000509841.1
    Conserved Domains (2) summary
    cd09803
    Location:234320
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:180339
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. NM_024873.6NP_079149.3  TNFAIP3-interacting protein 3 isoform 1

    See identical proteins and their annotated locations for NP_079149.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest protein (isoform 1).
    Source sequence(s)
    AC105254, AK024815, AK290409, CD367219
    Consensus CDS
    CCDS3718.1
    UniProtKB/Swiss-Prot
    Q96KP6
    Related
    ENSP00000057513.3, ENST00000057513.8
    Conserved Domains (2) summary
    cd09803
    Location:157243
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:103262
    TACC; Transforming acidic coiled-coil-containing protein (TACC)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    121131408..121227609 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008621.2XP_016864110.1  TNFAIP3-interacting protein 3 isoform X4

  2. XM_011532257.3XP_011530559.1  TNFAIP3-interacting protein 3 isoform X7

    Conserved Domains (2) summary
    cd09803
    Location:264350
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:210369
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  3. XM_011532256.2XP_011530558.1  TNFAIP3-interacting protein 3 isoform X3

    Conserved Domains (2) summary
    cd09803
    Location:264350
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:210369
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  4. XM_017008619.2XP_016864108.1  TNFAIP3-interacting protein 3 isoform X1

  5. XM_017008623.2XP_016864112.1  TNFAIP3-interacting protein 3 isoform X6

  6. XM_017008620.2XP_016864109.1  TNFAIP3-interacting protein 3 isoform X2

  7. XM_017008622.2XP_016864111.1  TNFAIP3-interacting protein 3 isoform X5

  8. XM_017008624.2XP_016864113.1  TNFAIP3-interacting protein 3 isoform X8

    Conserved Domains (2) summary
    cd09803
    Location:157243
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:103262
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
  9. XM_017008625.2XP_016864114.1  TNFAIP3-interacting protein 3 isoform X8

    Conserved Domains (2) summary
    cd09803
    Location:157243
    UBAN; polyubiquitin binding domain of NEMO and related proteins
    pfam05010
    Location:103262
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
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