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ZC3H14 zinc finger CCCH-type containing 14 [ Homo sapiens (human) ]

Gene ID: 79882, updated on 7-Jun-2020

Summary

Official Symbol
ZC3H14provided by HGNC
Official Full Name
zinc finger CCCH-type containing 14provided by HGNC
Primary source
HGNC:HGNC:20509
See related
Ensembl:ENSG00000100722 MIM:613279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SUT2; MRT56; UKp68; MSUT-2; NY-REN-37
Summary
The protein encoded by this gene is a poly(A)-binding protein that can affect gene expression and poly(A) tail length. The encoded protein may influence mRNA stability, nuclear export, and translation. [provided by RefSeq, May 2016]
Expression
Broad expression in testis (RPKM 19.6), thyroid (RPKM 8.3) and 25 other tissues See more
Orthologs

Genomic context

See ZC3H14 in Genome Data Viewer
Location:
14q31.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (88562982..88627596)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (89029253..89079853)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 7 Neighboring gene protein tyrosine phosphatase non-receptor type 21 Neighboring gene uncharacterized LOC105370614 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene EMAP like 5 Neighboring gene RNA, U4 small nuclear 92, pseudogene Neighboring gene tetratricopeptide repeat domain 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11806, MGC26892

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 14
Names
mammalian suppressor of tau pathology-2
nuclear protein UKp68
renal carcinoma antigen NY-REN-37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050601.1 RefSeqGene

    Range
    5001..55601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001160103.2NP_001153575.1  zinc finger CCCH domain-containing protein 14 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (5) lacks one-aa near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AL162171, AL359625, BC011793, BC023641, BC034274, BX248769, DB452844
    UniProtKB/Swiss-Prot
    Q6PJT7
    Conserved Domains (1) summary
    pfam14608
    Location:621639
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  2. NM_001160104.2NP_001153576.1  zinc finger CCCH domain-containing protein 14 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two alternate in-frame splice sites in the 3' coding region, compared to variant 1. The resulting isoform (6) lacks a five-aa and a one-aa segment, compared to isoform 1.
    Source sequence(s)
    AK304275, AL162171, AL359625, BC011793, BC034274, BX248769, DB452844
    Consensus CDS
    CCDS55938.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000452475.1, ENST00000555755.5
    Conserved Domains (1) summary
    pfam14608
    Location:616634
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  3. NM_001326295.2NP_001313224.1  zinc finger CCCH domain-containing protein 14 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Consensus CDS
    CCDS86417.1
    UniProtKB/TrEMBL
    G3V256
    Related
    ENSP00000450474.1, ENST00000556945.5
    Conserved Domains (1) summary
    pfam14608
    Location:551567
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  4. NM_001326296.2NP_001313225.1  zinc finger CCCH domain-containing protein 14 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL162171
  5. NM_001326297.2NP_001313226.1  zinc finger CCCH domain-containing protein 14 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:587605
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  6. NM_001326298.2NP_001313227.1  zinc finger CCCH domain-containing protein 14 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:526542
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  7. NM_001326299.2NP_001313228.1  zinc finger CCCH domain-containing protein 14 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL162171
  8. NM_001326300.2NP_001313229.1  zinc finger CCCH domain-containing protein 14 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:527543
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  9. NM_001326301.2NP_001313230.1  zinc finger CCCH domain-containing protein 14 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL162171
  10. NM_001326302.2NP_001313231.1  zinc finger CCCH domain-containing protein 14 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:526542
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  11. NM_001326303.2NP_001313232.1  zinc finger CCCH domain-containing protein 14 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:491507
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  12. NM_001326304.2NP_001313233.1  zinc finger CCCH domain-containing protein 14 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:395411
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  13. NM_001326305.2NP_001313234.1  zinc finger CCCH domain-containing protein 14 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:502518
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  14. NM_001326306.2NP_001313235.1  zinc finger CCCH domain-containing protein 14 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:473489
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  15. NM_001326307.2NP_001313236.1  zinc finger CCCH domain-containing protein 14 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Consensus CDS
    CCDS86418.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000377150.5, ENST00000393514.9
    Conserved Domains (1) summary
    pfam14608
    Location:596614
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  16. NM_001326308.2NP_001313237.1  zinc finger CCCH domain-containing protein 14 isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:396412
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  17. NM_001326309.2NP_001313238.1  zinc finger CCCH domain-containing protein 14 isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:371387
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  18. NM_001326310.2NP_001313239.1  zinc finger CCCH domain-containing protein 14 isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:616634
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  19. NM_001326311.2NP_001313240.1  zinc finger CCCH domain-containing protein 14 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL162171
    UniProtKB/TrEMBL
    A0A024R6F2
    Related
    ENSP00000452370.1, ENST00000557607.5
    Conserved Domains (1) summary
    pfam14608
    Location:370386
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  20. NM_001326312.2NP_001313241.1  zinc finger CCCH domain-containing protein 14 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL162171
  21. NM_001326313.2NP_001313242.1  zinc finger CCCH domain-containing protein 14 isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:474490
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  22. NM_001326314.2NP_001313243.1  zinc finger CCCH domain-containing protein 14 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL162171
    Conserved Domains (1) summary
    pfam14608
    Location:501517
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  23. NM_001326315.2NP_001313244.1  zinc finger CCCH domain-containing protein 14 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) and variant 28 both encode the same isoform (27).
    Source sequence(s)
    AL162171
  24. NM_001326316.1NP_001313245.1  zinc finger CCCH domain-containing protein 14 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) and variant 27 both encode the same isoform (27).
    Source sequence(s)
    AL162171
    Related
    ENSP00000451054.1, ENST00000556000.5
  25. NM_024824.5NP_079100.2  zinc finger CCCH domain-containing protein 14 isoform 1

    See identical proteins and their annotated locations for NP_079100.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL162171, AL359625, BC011793, BC034274, BX248769, DB452844
    Consensus CDS
    CCDS32133.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000251038.5, ENST00000251038.10
    Conserved Domains (1) summary
    pfam14608
    Location:621639
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  26. NM_207660.4NP_997543.1  zinc finger CCCH domain-containing protein 14 isoform 2

    See identical proteins and their annotated locations for NP_997543.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons in the central coding region and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment and one-aa near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AL162171, AL359625, AY578061, BC034274, BX248769
    Consensus CDS
    CCDS32134.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000307025.8, ENST00000302216.12
    Conserved Domains (1) summary
    pfam14608
    Location:525541
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  27. NM_207661.2NP_997544.1  zinc finger CCCH domain-containing protein 14 isoform 3

    See identical proteins and their annotated locations for NP_997544.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter, uses a downstream start codon, and lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus and lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AF474376, AY578062, BC034274, BX248769
    Consensus CDS
    CCDS32135.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000338002.4, ENST00000336693.8
    Conserved Domains (1) summary
    pfam14608
    Location:517533
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  28. NM_207662.4NP_997545.2  zinc finger CCCH domain-containing protein 14 isoform 4

    See identical proteins and their annotated locations for NP_997545.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter, lacks two alternate exons in the central coding region, and uses an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, and lacks an internal segment and one-aa near the C-terminus, compared to isoform 1.
    Source sequence(s)
    AL162171, AL359625, BC027607, BC034274, BX248769, DB050247
    Consensus CDS
    CCDS32136.1
    UniProtKB/Swiss-Prot
    Q6PJT7
    Related
    ENSP00000327176.6, ENST00000318308.10
    Conserved Domains (1) summary
    pfam14608
    Location:252268
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

RNA

  1. NR_136936.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL162171

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    88562982..88627596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268070.5XP_005268127.1  zinc finger CCCH domain-containing protein 14 isoform X2

    See identical proteins and their annotated locations for XP_005268127.1

    Conserved Domains (1) summary
    pfam14608
    Location:490508
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  2. XM_011537161.3XP_011535463.1  zinc finger CCCH domain-containing protein 14 isoform X1

    Conserved Domains (1) summary
    pfam14608
    Location:569587
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  3. XM_011537162.3XP_011535464.1  zinc finger CCCH domain-containing protein 14 isoform X3

  4. XM_024449713.1XP_024305481.1  zinc finger CCCH domain-containing protein 14 isoform X6

    Conserved Domains (1) summary
    pfam14608
    Location:358374
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  5. XM_005268073.4XP_005268130.1  zinc finger CCCH domain-containing protein 14 isoform X4

    See identical proteins and their annotated locations for XP_005268130.1

    UniProtKB/TrEMBL
    G3V411
    Related
    ENSP00000451530.1, ENST00000555900.5
    Conserved Domains (1) summary
    pfam14608
    Location:384400
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  6. XM_006720257.3XP_006720320.1  zinc finger CCCH domain-containing protein 14 isoform X5

    Conserved Domains (1) summary
    pfam14608
    Location:359375
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
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