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Zc3h14 zinc finger CCCH type containing 14 [ Mus musculus (house mouse) ]

Gene ID: 75553, updated on 1-Mar-2024

Summary

Official Symbol
Zc3h14provided by MGI
Official Full Name
zinc finger CCCH type containing 14provided by MGI
Primary source
MGI:MGI:1919824
See related
Ensembl:ENSMUSG00000021012 AllianceGenome:MGI:1919824
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1010001P15Rik; 1700016A15Rik; 2700069A02Rik
Summary
Predicted to enable poly(A) binding activity. Predicted to be involved in negative regulation of mRNA polyadenylation and regulation of mRNA stability. Located in nuclear speck. Is expressed in cerebral cortex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ZC3H14 (zinc finger CCCH-type containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 36.2), CNS E11.5 (RPKM 18.5) and 24 other tissues See more
Orthologs
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Genomic context

See Zc3h14 in Genome Data Viewer
Location:
12 E; 12 49.88 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98708276..98754033)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98742017..98787774)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 7 Neighboring gene STARR-seq mESC enhancer starr_33000 Neighboring gene protein tyrosine phosphatase, non-receptor type 21 Neighboring gene STARR-positive B cell enhancer ABC_E9861 Neighboring gene echinoderm microtubule associated protein like 5 Neighboring gene predicted gene, 35463 Neighboring gene STARR-seq mESC enhancer starr_33001 Neighboring gene STARR-seq mESC enhancer starr_33002 Neighboring gene STARR-positive B cell enhancer ABC_E5348 Neighboring gene tetratricopeptide repeat domain 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables poly(A) binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of mRNA polyadenylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger CCCH domain-containing protein 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008506.2NP_001008506.2  zinc finger CCCH domain-containing protein 14 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC159193, AK048046, AK076066, AK160937
    Consensus CDS
    CCDS26099.1
    UniProtKB/Swiss-Prot
    Q8BJ05
    Related
    ENSMUSP00000105731.3, ENSMUST00000110104.10
    Conserved Domains (1) summary
    pfam14608
    Location:490508
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  2. NM_001160107.1NP_001153579.1  zinc finger CCCH domain-containing protein 14 isoform c

    See identical proteins and their annotated locations for NP_001153579.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons in the central coding region, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC159193, AK048046, AK076066, AK160937
    Consensus CDS
    CCDS49138.1
    UniProtKB/Swiss-Prot
    Q8BJ05
    Related
    ENSMUSP00000055879.10, ENSMUST00000057000.17
    Conserved Domains (1) summary
    pfam14608
    Location:525541
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  3. NM_001160108.1NP_001153580.1  zinc finger CCCH domain-containing protein 14 isoform d

    See identical proteins and their annotated locations for NP_001153580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and lacks two alternate exons in the central coding region, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform a.
    Source sequence(s)
    AC159193, AK006009, AK160937, BU936221
    Consensus CDS
    CCDS49139.1
    UniProtKB/Swiss-Prot
    Q8BJ05
    Related
    ENSMUSP00000021399.8, ENSMUST00000021399.9
    Conserved Domains (1) summary
    COG5084
    Location:179273
    YTH1; Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins [General function prediction only]
  4. NM_001364400.1NP_001351329.1  zinc finger CCCH domain-containing protein 14 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC159193
    Conserved Domains (1) summary
    pfam14608
    Location:677693
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  5. NM_001364401.1NP_001351330.1  zinc finger CCCH domain-containing protein 14 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC159193
    Conserved Domains (1) summary
    pfam14608
    Location:656672
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  6. NM_001364402.1NP_001351331.1  zinc finger CCCH domain-containing protein 14 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC159193
    Conserved Domains (1) summary
    pfam14608
    Location:546562
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  7. NM_001364403.1NP_001351332.1  zinc finger CCCH domain-containing protein 14 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC159193
    Conserved Domains (1) summary
    pfam14608
    Location:526542
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  8. NM_001364404.1NP_001351333.1  zinc finger CCCH domain-containing protein 14 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC159193
    Conserved Domains (1) summary
    pfam14608
    Location:395411
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  9. NM_001364405.1NP_001351334.1  zinc finger CCCH domain-containing protein 14 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC159193
    Conserved Domains (1) summary
    pfam14608
    Location:370386
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  10. NM_029334.2NP_083610.2  zinc finger CCCH domain-containing protein 14 isoform a

    See identical proteins and their annotated locations for NP_083610.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC159193, AK048046, AK076066, AK160937
    Consensus CDS
    CCDS26100.1
    UniProtKB/Swiss-Prot
    A0PJE7, A1A4A9, Q3TU70, Q8BIY8, Q8BJ05, Q8R3Q8, Q8R3R2, Q9DAA8
    Related
    ENSMUSP00000105732.3, ENSMUST00000110105.10
    Conserved Domains (1) summary
    pfam14608
    Location:621639
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

RNA

  1. NR_027648.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 5' coding region and three alternate exons in the central coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC159193, AK076066, AK160937

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    98708276..98754033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516327.4XP_006516390.3  zinc finger CCCH domain-containing protein 14 isoform X1

    Conserved Domains (1) summary
    pfam14608
    Location:739755
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  2. XM_006516328.4XP_006516391.3  zinc finger CCCH domain-containing protein 14 isoform X2

    Conserved Domains (1) summary
    pfam14608
    Location:714730
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  3. XM_006516330.4XP_006516393.3  zinc finger CCCH domain-containing protein 14 isoform X4

    Conserved Domains (1) summary
    pfam14608
    Location:583599
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  4. XM_006516329.4XP_006516392.3  zinc finger CCCH domain-containing protein 14 isoform X3

    Conserved Domains (1) summary
    pfam14608
    Location:608624
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  5. XM_030246973.2XP_030102833.1  zinc finger CCCH domain-containing protein 14 isoform X5

    Conserved Domains (1) summary
    pfam14608
    Location:501517
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger
  6. XM_006516333.3XP_006516396.1  zinc finger CCCH domain-containing protein 14 isoform X6

    Conserved Domains (1) summary
    pfam14608
    Location:386402
    zf-CCCH_2; RNA-binding, Nab2-type zinc finger

RNA

  1. XR_001780498.2 RNA Sequence

  2. XR_001780499.3 RNA Sequence