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RPAP2 RNA polymerase II associated protein 2 [ Homo sapiens (human) ]

Gene ID: 79871, updated on 3-May-2020

Summary

Official Symbol
RPAP2provided by HGNC
Official Full Name
RNA polymerase II associated protein 2provided by HGNC
Primary source
HGNC:HGNC:25791
See related
Ensembl:ENSG00000122484 MIM:611476
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Rtr1; C1orf82
Expression
Ubiquitous expression in thyroid (RPKM 2.5), endometrium (RPKM 2.0) and 25 other tissues See more
Orthologs

Genomic context

See RPAP2 in Genome Data Viewer
Location:
1p22.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (92299050..92402056)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (92764522..92853732)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 510 pseudogene Neighboring gene chromosome 1 open reading frame 146 Neighboring gene ACTB pseudogene 12 Neighboring gene glomulin, FKBP associated protein Neighboring gene RNA, 7SL, cytoplasmic 824, pseudogene Neighboring gene growth factor independent 1 transcriptional repressor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13150

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II CTD heptapeptide repeat phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II CTD heptapeptide repeat phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA polymerase core enzyme binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity EXP
Inferred from Experiment
more info
PubMed 
Process Evidence Code Pubs
dephosphorylation of RNA polymerase II C-terminal domain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dephosphorylation of RNA polymerase II C-terminal domain IMP
Inferred from Mutant Phenotype
more info
PubMed 
snRNA transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
RNA polymerase II, holoenzyme IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
NP_079089.2
XP_005271280.1
XP_011540469.1
XP_016857851.1
XP_016857852.1
XP_016857853.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024813.3NP_079089.2  putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

    See identical proteins and their annotated locations for NP_079089.2

    Status: VALIDATED

    Source sequence(s)
    AC104456, AI612918, AL451010, BC039014
    Consensus CDS
    CCDS740.1
    UniProtKB/Swiss-Prot
    Q8IXW5
    Related
    ENSP00000476948.1, ENST00000610020.2
    Conserved Domains (1) summary
    pfam04181
    Location:80152
    RPAP2_Rtr1; Rtr1/RPAP2 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    92299050..92402056
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271223.3XP_005271280.1  putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 isoform X5

    Conserved Domains (1) summary
    pfam04181
    Location:80152
    RPAP2_Rtr1; Rtr1/RPAP2 family
  2. XM_017002362.2XP_016857851.1  putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 isoform X1

  3. XM_017002363.2XP_016857852.1  putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 isoform X2

  4. XM_011542167.3XP_011540469.1  putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 isoform X3

    Conserved Domains (1) summary
    pfam04181
    Location:80152
    RPAP2_Rtr1; Rtr1/RPAP2 family
  5. XM_017002364.2XP_016857853.1  putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 isoform X4

    Conserved Domains (1) summary
    pfam04181
    Location:80152
    RPAP2_Rtr1; Rtr1/RPAP2 family

RNA

  1. XR_246295.3 RNA Sequence

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