Format

Send to:

Choose Destination

ARHGAP28 Rho GTPase activating protein 28 [ Homo sapiens (human) ]

Gene ID: 79822, updated on 24-Nov-2020

Summary

Official Symbol
ARHGAP28provided by HGNC
Official Full Name
Rho GTPase activating protein 28provided by HGNC
Primary source
HGNC:HGNC:25509
See related
Ensembl:ENSG00000088756 MIM:610592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 21.0), placenta (RPKM 7.7) and 10 other tissues See more
Orthologs

Genomic context

See ARHGAP28 in Genome Data Viewer
Location:
18p11.31
Exon count:
20
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (6729716..6915716)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (6729717..6915715)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1387 Neighboring gene uncharacterized LOC105371972 Neighboring gene uncharacterized LOC107985176 Neighboring gene RNA, 7SL, cytoplasmic 282, pseudogene Neighboring gene ARHGAP28 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 668 Neighboring gene RNA, U6 small nuclear 916, pseudogene Neighboring gene SCML2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10312, FLJ27160, DKFZp686A2038

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 28
Names
rho-type GTPase-activating protein 28

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010000.3NP_001010000.1  rho GTPase-activating protein 28 isoform a

    See identical proteins and their annotated locations for NP_001010000.1

    Status: VALIDATED

    Source sequence(s)
    AI435330, AK302026, AP005210, BX648684
    Consensus CDS
    CCDS32785.1
    UniProtKB/TrEMBL
    B4DXL2
    Related
    ENSP00000392660.2, ENST00000419673.6
    Conserved Domains (1) summary
    cd04391
    Location:218429
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
  2. NM_001366230.1NP_001353159.1  rho GTPase-activating protein 28 isoform c

    Status: VALIDATED

    Source sequence(s)
    AP005205, AP005210
    Related
    ENSP00000372964.4, ENST00000383472.8
    Conserved Domains (1) summary
    cd04391
    Location:377588
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
  3. NM_001366231.1NP_001353160.1  rho GTPase-activating protein 28 isoform d

    Status: VALIDATED

    Source sequence(s)
    AP005205, AP005210
    Related
    ENSP00000262227.3, ENST00000262227.7
    Conserved Domains (1) summary
    cd04391
    Location:377588
    RhoGAP_ARHGAP18; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    6729716..6915716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258146.2XP_005258203.1  rho GTPase-activating protein 28 isoform X3

    Conserved Domains (1) summary
    cd04391
    Location:395580
    RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030672.2: Suppressed sequence

    Description
    NM_030672.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center