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DNAI4 dynein axonemal intermediate chain 4 [ Homo sapiens (human) ]

Gene ID: 79819, updated on 1-Jun-2020

Summary

Official Symbol
DNAI4provided by HGNC
Official Full Name
dynein axonemal intermediate chain 4provided by HGNC
Primary source
HGNC:HGNC:26252
See related
Ensembl:ENSG00000152763
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIC4; WDR78
Expression
Biased expression in testis (RPKM 11.4), thyroid (RPKM 2.6) and 9 other tissues See more
Orthologs

Genomic context

See DNAI4 in Genome Data Viewer
Location:
1p31.3
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (66812885..66924856, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (67278568..67390907, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Tctex1 domain containing 1 Neighboring gene insulin like 5 Neighboring gene MIER1 transcriptional regulator Neighboring gene solute carrier family 35 member D1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23129

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dynein light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axonemal dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
WD repeat-containing protein 78
Names
WD repeat domain 78

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024763.5NP_079039.4  WD repeat-containing protein 78 isoform 1

    See identical proteins and their annotated locations for NP_079039.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL133617, BC126381, DA916550
    Consensus CDS
    CCDS635.1
    UniProtKB/Swiss-Prot
    Q5VTH9
    UniProtKB/TrEMBL
    A0AVI9
    Related
    ENSP00000360065.3, ENST00000371026.8
    Conserved Domains (3) summary
    COG2319
    Location:485845
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:707744
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:493775
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_207014.3NP_996897.2  WD repeat-containing protein 78 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC032406, DA916550
    Consensus CDS
    CCDS44157.1
    UniProtKB/Swiss-Prot
    Q5VTH9
    Related
    ENSP00000360062.3, ENST00000371023.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    66812885..66924856 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002354.1XP_016857843.1  WD repeat-containing protein 78 isoform X6

  2. XM_017002353.1XP_016857842.1  WD repeat-containing protein 78 isoform X5

  3. XM_005271212.3XP_005271269.1  WD repeat-containing protein 78 isoform X3

    Conserved Domains (3) summary
    COG2319
    Location:420780
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:642679
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:428710
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_011542161.2XP_011540463.1  WD repeat-containing protein 78 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:482816
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:678715
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:509746
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_024449820.1XP_024305588.1  WD repeat-containing protein 78 isoform X8

    Conserved Domains (2) summary
    COG2319
    Location:196536
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:418455
    7WD40; WD40 repeat [structural motif]
  6. XM_024449816.1XP_024305584.1  WD repeat-containing protein 78 isoform X4

    Conserved Domains (2) summary
    COG2319
    Location:413773
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:635672
    7WD40; WD40 repeat [structural motif]
  7. XM_024449817.1XP_024305585.1  WD repeat-containing protein 78 isoform X4

    Conserved Domains (2) summary
    COG2319
    Location:413773
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:635672
    7WD40; WD40 repeat [structural motif]
  8. XM_024449821.1XP_024305589.1  WD repeat-containing protein 78 isoform X8

    Conserved Domains (2) summary
    COG2319
    Location:196536
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:418455
    7WD40; WD40 repeat [structural motif]
  9. XM_017002355.1XP_016857844.1  WD repeat-containing protein 78 isoform X7

    Related
    ENSP00000433682.1, ENST00000464352.6
  10. XM_011542162.2XP_011540464.1  WD repeat-containing protein 78 isoform X2

    Conserved Domains (3) summary
    COG2319
    Location:488812
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:539583
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:538800
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_017002357.1XP_016857846.1  WD repeat-containing protein 78 isoform X9

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