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NSUN7 NOP2/Sun RNA methyltransferase family member 7 [ Homo sapiens (human) ]

Gene ID: 79730, updated on 23-Nov-2021

Summary

Official Symbol
NSUN7provided by HGNC
Official Full Name
NOP2/Sun RNA methyltransferase family member 7provided by HGNC
Primary source
HGNC:HGNC:25857
See related
Ensembl:ENSG00000179299 MIM:617185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 10.8), thyroid (RPKM 2.4) and 19 other tissues See more
Orthologs
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Genomic context

See NSUN7 in Genome Data Viewer
Location:
4p14
Exon count:
14
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (40749874..40815729)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (40751972..40813201)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 47 Neighboring gene microRNA 4802 Neighboring gene uncharacterized LOC107986225 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 2 Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene Sharpr-MPRA regulatory region 11490 Neighboring gene uncharacterized LOC107986273

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14001

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative methyltransferase NSUN7
Names
NOL1/NOP2/Sun domain family member 7
NOP2/Sun domain family, member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330648.3NP_001317577.1  putative methyltransferase NSUN7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC131953
    Consensus CDS
    CCDS82917.1
    UniProtKB/Swiss-Prot
    Q8NE18
    Related
    ENSP00000319127.5, ENST00000316607.5
  2. NM_024677.6NP_078953.4  putative methyltransferase NSUN7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131953
    Consensus CDS
    CCDS3461.2
    Related
    ENSP00000371201.2, ENST00000381782.7
    Conserved Domains (1) summary
    cl25484
    Location:131509
    Methyltr_RsmF_N; N-terminal domain of 16S rRNA methyltransferase RsmF

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    40749874..40815729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008611.2XP_016864100.1  putative methyltransferase NSUN7 isoform X1

  2. XM_017008612.2XP_016864101.1  putative methyltransferase NSUN7 isoform X2

  3. XM_017008613.1XP_016864102.1  putative methyltransferase NSUN7 isoform X3

  4. XM_017008615.1XP_016864104.1  putative methyltransferase NSUN7 isoform X4

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