U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NSUN7 NOP2/Sun RNA methyltransferase family member 7 [ Homo sapiens (human) ]

Gene ID: 79730, updated on 6-Nov-2022

Summary

Official Symbol
NSUN7provided by HGNC
Official Full Name
NOP2/Sun RNA methyltransferase family member 7provided by HGNC
Primary source
HGNC:HGNC:25857
See related
Ensembl:ENSG00000179299 MIM:617185; AllianceGenome:HGNC:25857
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable RNA binding activity and methyltransferase activity. Predicted to be involved in methylation. Predicted to act upstream of or within flagellated sperm motility and sperm mitochondrion organization. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 10.8), thyroid (RPKM 2.4) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See NSUN7 in Genome Data Viewer
Location:
4p14
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (40749955..40811184)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (40723823..40785135)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (40751972..40813201)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 47 Neighboring gene ribosomal protein L37 pseudogene 14 Neighboring gene microRNA 4802 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 2 Neighboring gene small nucleolar RNA U13 Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:40899403-40899903

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14001

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative methyltransferase NSUN7
Names
NOL1/NOP2/Sun domain family member 7
NOP2/Sun domain family, member 7

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330648.3NP_001317577.1  putative methyltransferase NSUN7 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC131953
    Consensus CDS
    CCDS82917.1
    UniProtKB/Swiss-Prot
    Q8NE18
    Related
    ENSP00000319127.5, ENST00000316607.5
  2. NM_024677.6NP_078953.4  putative methyltransferase NSUN7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131953
    Consensus CDS
    CCDS3461.2
    UniProtKB/Swiss-Prot
    Q9H815
    Related
    ENSP00000371201.2, ENST00000381782.7
    Conserved Domains (1) summary
    cl25484
    Location:131509
    Methyltr_RsmF_N; N-terminal domain of 16S rRNA methyltransferase RsmF

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    40749955..40811184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008611.3XP_016864100.1  putative methyltransferase NSUN7 isoform X1

  2. XM_047416171.1XP_047272127.1  putative methyltransferase NSUN7 isoform X3

  3. XM_017008612.3XP_016864101.1  putative methyltransferase NSUN7 isoform X2

  4. XM_047416175.1XP_047272131.1  putative methyltransferase NSUN7 isoform X6

  5. XM_017008615.2XP_016864104.1  putative methyltransferase NSUN7 isoform X5

  6. XM_047416172.1XP_047272128.1  putative methyltransferase NSUN7 isoform X4

  7. XM_047416174.1XP_047272130.1  putative methyltransferase NSUN7 isoform X4

  8. XM_047416173.1XP_047272129.1  putative methyltransferase NSUN7 isoform X4

RNA

  1. XR_007057964.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    40723823..40785135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)