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Nsun7 NOL1/NOP2/Sun domain family, member 7 [ Mus musculus (house mouse) ]

Gene ID: 70918, updated on 6-Jun-2024

Summary

Official Symbol
Nsun7provided by MGI
Official Full Name
NOL1/NOP2/Sun domain family, member 7provided by MGI
Primary source
MGI:MGI:1918168
See related
Ensembl:ENSMUSG00000029206 AllianceGenome:MGI:1918168
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921525L17Rik
Summary
This gene encodes a member of the NOL1/NOP2/sun domain RNA methyltransferase family. Mice with a mutation in this gene exhibit male sterility due to impaired sperm motility. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Expression
Biased expression in testis adult (RPKM 9.7), frontal lobe adult (RPKM 1.4) and 6 other tissues See more
Orthologs
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Genomic context

See Nsun7 in Genome Data Viewer
Location:
5 C3.1; 5 34.34 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (66417181..66457544)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (66259838..66299927)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700126H18 gene Neighboring gene predicted gene 43772 Neighboring gene STARR-seq mESC enhancer starr_13286 Neighboring gene STARR-seq mESC enhancer starr_13287 Neighboring gene STARR-seq mESC enhancer starr_13288 Neighboring gene predicted gene 15794 Neighboring gene STARR-seq mESC enhancer starr_13289 Neighboring gene STARR-seq mESC enhancer starr_13290 Neighboring gene STARR-seq mESC enhancer starr_13291 Neighboring gene amyloid beta precursor protein binding family B member 2 Neighboring gene STARR-seq mESC enhancer starr_13293 Neighboring gene STARR-seq mESC enhancer starr_13294 Neighboring gene predicted gene, 52775 Neighboring gene ubiquitin carboxy-terminal hydrolase L1, opposite strand Neighboring gene ubiquitin carboxy-terminal hydrolase L1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General protein information

Preferred Names
putative methyltransferase NSUN7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302833.2NP_001289762.1  putative methyltransferase NSUN7 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC131752
    Consensus CDS
    CCDS80290.1
    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    UniProtKB/TrEMBL
    E9QL78, E9QPI2
    Related
    ENSMUSP00000031109.5, ENSMUST00000031109.7
    Conserved Domains (1) summary
    cl17173
    Location:346460
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001302834.2NP_001289763.1  putative methyltransferase NSUN7 isoform 2

    See identical proteins and their annotated locations for NP_001289763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region and differs in the 3' exon structure, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC131752
    Consensus CDS
    CCDS80291.1
    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    Related
    ENSMUSP00000144498.2, ENSMUST00000202994.4
    Conserved Domains (1) summary
    cl17173
    Location:346426
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_001400914.1NP_001387843.1  putative methyltransferase NSUN7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC131752
    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
  4. NM_027602.3NP_081878.1  putative methyltransferase NSUN7 isoform 3

    See identical proteins and their annotated locations for NP_081878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks the 5' terminal exon and uses an alternate splice site in the 3' terminal exon resulting in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC131752
    Consensus CDS
    CCDS19314.1
    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    UniProtKB/TrEMBL
    A0A0J9YV71
    Conserved Domains (1) summary
    COG0144
    Location:338515
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    66417181..66457544
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321098.2XP_017176587.1  putative methyltransferase NSUN7 isoform X4

  2. XM_011240769.4XP_011239071.1  putative methyltransferase NSUN7 isoform X2

    See identical proteins and their annotated locations for XP_011239071.1

    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    UniProtKB/TrEMBL
    A0A0J9YV71
    Related
    ENSMUSP00000144520.2, ENSMUST00000201100.4
    Conserved Domains (1) summary
    COG0144
    Location:338515
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  3. XM_006504102.5XP_006504165.1  putative methyltransferase NSUN7 isoform X1

    See identical proteins and their annotated locations for XP_006504165.1

    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    Conserved Domains (1) summary
    COG0144
    Location:338515
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  4. XM_030254806.2XP_030110666.1  putative methyltransferase NSUN7 isoform X3

    UniProtKB/Swiss-Prot
    Q14AW5, Q8BS48, Q9D5S9
    Conserved Domains (1) summary
    COG0144
    Location:203380
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  5. XM_006504105.5XP_006504168.1  putative methyltransferase NSUN7 isoform X5

    See identical proteins and their annotated locations for XP_006504168.1

    Conserved Domains (1) summary
    COG0144
    Location:35212
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
  6. XM_006504106.5XP_006504169.1  putative methyltransferase NSUN7 isoform X5

    See identical proteins and their annotated locations for XP_006504169.1

    Conserved Domains (1) summary
    COG0144
    Location:35212
    RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

RNA

  1. XR_004942559.1 RNA Sequence