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MORC4 MORC family CW-type zinc finger 4 [ Homo sapiens (human) ]

Gene ID: 79710, updated on 6-Nov-2022

Summary

Official Symbol
MORC4provided by HGNC
Official Full Name
MORC family CW-type zinc finger 4provided by HGNC
Primary source
HGNC:HGNC:23485
See related
Ensembl:ENSG00000133131 MIM:300970; AllianceGenome:HGNC:23485
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZCW4; ZCWCC2; dJ75H8.2
Summary
In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
Expression
Broad expression in placenta (RPKM 38.5), adrenal (RPKM 15.2) and 18 other tissues See more
Orthologs
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Genomic context

See MORC4 in Genome Data Viewer
Location:
Xq22.3
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (106940738..107000212, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (105377254..105436736, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106183968..106243442, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 8B Neighboring gene ripply transcriptional repressor 1 Neighboring gene claudin 2 Neighboring gene Sharpr-MPRA regulatory region 10711 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 40 Neighboring gene RNA binding motif protein 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11565

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MORC family CW-type zinc finger protein 4
Names
zinc finger CW-type coiled-coil domain protein 2
zinc finger CW-type domain protein 4
zinc finger, CW type with coiled-coil domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016392.1 RefSeqGene

    Range
    5033..64507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001085354.3NP_001078823.1  MORC family CW-type zinc finger protein 4 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the CDS compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AK300305, BQ101064, CA448781, CB989767, EF125209
    Consensus CDS
    CCDS48146.1
    UniProtKB/Swiss-Prot
    Q8TE76
    UniProtKB/TrEMBL
    B4DTP6
    Related
    ENSP00000255495.7, ENST00000255495.7
    Conserved Domains (3) summary
    pfam06625
    Location:762814
    DUF1151; Protein of unknown function (DUF1151)
    pfam07496
    Location:425469
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:50170
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins
  2. NM_024657.5NP_078933.3  MORC family CW-type zinc finger protein 4 isoform a

    See identical proteins and their annotated locations for NP_078933.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK300305, BQ101064, CA448781, CB989767, EF125209
    Consensus CDS
    CCDS14525.2
    UniProtKB/Swiss-Prot
    Q8TE76, Q9HAI7
    UniProtKB/TrEMBL
    B4DTP6
    Related
    ENSP00000347821.4, ENST00000355610.9
    Conserved Domains (3) summary
    pfam06625
    Location:762814
    DUF1151; Protein of unknown function (DUF1151)
    pfam07496
    Location:425469
    zf-CW; CW-type Zinc Finger
    cl00075
    Location:50170
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    106940738..107000212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    105377254..105436736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)