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ZMAT4 zinc finger matrin-type 4 [ Homo sapiens (human) ]

Gene ID: 79698, updated on 11-Jun-2021

Summary

Official Symbol
ZMAT4provided by HGNC
Official Full Name
zinc finger matrin-type 4provided by HGNC
Primary source
HGNC:HGNC:25844
See related
Ensembl:ENSG00000165061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in thyroid (RPKM 4.9) and brain (RPKM 1.9) See more
Orthologs
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Genomic context

See ZMAT4 in Genome Data Viewer
Location:
8p11.21
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (40522766..40897828, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (40388109..40755345, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379388 Neighboring gene SIRT1 regulating lncRNA tumor promoter Neighboring gene uncharacterized LOC107986938 Neighboring gene uncharacterized LOC105379389 Neighboring gene uncharacterized LOC105379390

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide association with diabetes-related traits in the Framingham Heart Study.
GeneReviews: Not available
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13842

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger matrin-type protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135731.2NP_001129203.1  zinc finger matrin-type protein 4 isoform b

    See identical proteins and their annotated locations for NP_001129203.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC048387, AK023904, BC019598
    Consensus CDS
    CCDS47848.1
    UniProtKB/Swiss-Prot
    Q9H898
    Related
    ENSP00000319785.7, ENST00000315769.11
    Conserved Domains (3) summary
    smart00451
    Location:72106
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:7799
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam19088
    Location:122153
    TUTase; TUTase nucleotidyltransferase domain
  2. NM_024645.3NP_078921.1  zinc finger matrin-type protein 4 isoform a

    See identical proteins and their annotated locations for NP_078921.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC048387, AK023904, BC019598
    Consensus CDS
    CCDS34885.1
    UniProtKB/Swiss-Prot
    Q9H898
    Related
    ENSP00000297737.6, ENST00000297737.11
    Conserved Domains (3) summary
    smart00451
    Location:142176
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:147169
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:198222
    zf-met; Zinc-finger of C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    40522766..40897828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447276.1XP_024303044.1  zinc finger matrin-type protein 4 isoform X3

    Conserved Domains (3) summary
    smart00451
    Location:96130
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:101123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:152176
    zf-met; Zinc-finger of C2H2 type
  2. XM_024447277.1XP_024303045.1  zinc finger matrin-type protein 4 isoform X3

    Conserved Domains (3) summary
    smart00451
    Location:96130
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:101123
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12874
    Location:152176
    zf-met; Zinc-finger of C2H2 type
  3. XM_017013837.2XP_016869326.1  zinc finger matrin-type protein 4 isoform X2

    Conserved Domains (2) summary
    smart00451
    Location:96130
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:3153
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. XM_017013836.2XP_016869325.1  zinc finger matrin-type protein 4 isoform X1

  5. XM_017013838.2XP_016869327.1  zinc finger matrin-type protein 4 isoform X2

    Conserved Domains (2) summary
    smart00451
    Location:96130
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:3153
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_024447275.1XP_024303043.1  zinc finger matrin-type protein 4 isoform X2

    Conserved Domains (2) summary
    smart00451
    Location:96130
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:3153
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_017013840.1XP_016869329.1  zinc finger matrin-type protein 4 isoform X4

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