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PANK3 pantothenate kinase 3 [ Homo sapiens (human) ]

Gene ID: 79646, updated on 1-Jun-2020

Summary

Official Symbol
PANK3provided by HGNC
Official Full Name
pantothenate kinase 3provided by HGNC
Primary source
HGNC:HGNC:19365
See related
Ensembl:ENSG00000120137 MIM:606161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is expressed most abundantly in the liver. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 27.0), colon (RPKM 21.4) and 25 other tissues See more
Orthologs

Genomic context

See PANK3 in Genome Data Viewer
Location:
5q34
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (168548495..168579368, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (167982628..168006614, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene arginyl-tRNA synthetase 1 Neighboring gene solute carrier family 2 member 3 pseudogene 1 Neighboring gene microRNA 103a-1 Neighboring gene microRNA 103b-1 Neighboring gene fibrillarin like 1 Neighboring gene ribosomal protein L10 pseudogene 9 Neighboring gene slit guidance ligand 3 Neighboring gene SLIT3 antisense RNA 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of pantothenate kinase 3 (PANK3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12899, MGC16863, DKFZp686O22247

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
acetyl-CoA binding IDA
Inferred from Direct Assay
more info
PubMed 
pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pantothenate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
pantothenate kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
vitamin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
coenzyme A biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
coenzyme A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pantothenate kinase 3
Names
hPanK3
pantothenic acid kinase 3
NP_078870.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024594.4NP_078870.1  pantothenate kinase 3

    See identical proteins and their annotated locations for NP_078870.1

    Status: REVIEWED

    Source sequence(s)
    AA831520, AC020894, BC013705, CB045475
    Consensus CDS
    CCDS4368.1
    UniProtKB/Swiss-Prot
    Q9H999
    Related
    ENSP00000239231.6, ENST00000239231.7
    Conserved Domains (1) summary
    pfam03630
    Location:14362
    Fumble; Fumble

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    168548495..168579368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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