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EFL1 elongation factor like GTPase 1 [ Homo sapiens (human) ]

Gene ID: 79631, updated on 12-Oct-2019

Summary

Official Symbol
EFL1provided by HGNC
Official Full Name
elongation factor like GTPase 1provided by HGNC
Primary source
HGNC:HGNC:25789
See related
Ensembl:ENSG00000140598 MIM:617538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIA1; SDS2; EFTUD1; FAM42A; HsT19294
Expression
Ubiquitous expression in testis (RPKM 7.4), small intestine (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See EFL1 in Genome Data Viewer
Location:
15q25.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (82130220..82262763, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (82422561..82555104, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene mex-3 RNA binding family member B Neighboring gene uncharacterized LOC105370924 Neighboring gene long intergenic non-protein coding RNA 1583 Neighboring gene RNA, U1 small nuclear 77, pseudogene Neighboring gene stabilizer of axonemal microtubules 2 Neighboring gene ADAMTS7 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of elongation factor Tu GTP binding domain containing 1 (EFTUD1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
GTP metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
mature ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mature ribosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational elongation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
elongation factor-like GTPase 1
Names
elongation factor Tu GTP binding domain containing 1
elongation factor Tu GTP-binding domain-containing protein 1
elongation factor-like 1
ribosome assembly 1 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040610.2NP_001035700.1  elongation factor-like GTPase 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC026624, AC026956, BC014628
    Consensus CDS
    CCDS42070.1
    UniProtKB/Swiss-Prot
    Q7Z2Z2
    Related
    ENSP00000352418.3, ENST00000359445.7
    Conserved Domains (6) summary
    cd01681
    Location:636935
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd04096
    Location:9321010
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:11052
    PTZ00416; elongation factor 2; Provisional
    cd16268
    Location:451549
    EF2_II; Domain II of Elongation Factor 2
    cd16261
    Location:565636
    EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)
    cl21455
    Location:20202
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001322844.1NP_001309773.1  elongation factor-like GTPase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC026624, AC026956
    Conserved Domains (4) summary
    cd01681
    Location:424723
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd04096
    Location:720798
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    cd16268
    Location:239337
    EF2_II; Domain II of Elongation Factor 2
    cd16261
    Location:353424
    EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)
  3. NM_001322845.1NP_001309774.1  elongation factor-like GTPase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC026624, AC026956
    Consensus CDS
    CCDS42071.1
    UniProtKB/Swiss-Prot
    Q7Z2Z2
    Conserved Domains (6) summary
    cd01885
    Location:20253
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:687986
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd04096
    Location:9831061
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:11103
    PTZ00416; elongation factor 2; Provisional
    cd16268
    Location:502600
    EF2_II; Domain II of Elongation Factor 2
    cd16261
    Location:616687
    EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)
  4. NM_024580.6NP_078856.4  elongation factor-like GTPase 1 isoform 1

    See identical proteins and their annotated locations for NP_078856.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the the longest isoform (1).
    Source sequence(s)
    AC026624, AC026956, BC014628
    Consensus CDS
    CCDS42071.1
    UniProtKB/Swiss-Prot
    Q7Z2Z2
    Related
    ENSP00000268206.7, ENST00000268206.12
    Conserved Domains (6) summary
    cd01885
    Location:20253
    EF2; Elongation Factor 2 (EF2) in archaea and eukarya
    cd01681
    Location:687986
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd04096
    Location:9831061
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    PTZ00416
    Location:11103
    PTZ00416; elongation factor 2; Provisional
    cd16268
    Location:502600
    EF2_II; Domain II of Elongation Factor 2
    cd16261
    Location:616687
    EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)

RNA

  1. NR_136410.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026624, AC026956
    Related
    ENST00000650113.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    82130220..82262763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522000.1XP_011520302.1  elongation factor-like GTPase 1 isoform X1

    See identical proteins and their annotated locations for XP_011520302.1

    Conserved Domains (4) summary
    cd01681
    Location:424723
    aeEF2_snRNP_like_IV; This family represents domain IV of archaeal and eukaryotic elongation factor 2 (aeEF-2) and of an evolutionarily conserved U5 snRNP-specific protein. U5 snRNP is a GTP-binding factor closely related to the ribosomal translocase EF-2. In complex with GTP, ...
    cd04096
    Location:720798
    eEF2_snRNP_like_C; eEF2_snRNP_like_C: this family represents a C-terminal domain of eukaryotic elongation factor 2 (eEF-2) and a homologous domain of the spliceosomal human 116kD U5 small nuclear ribonucleoprotein (snRNP) protein (U5-116 kD) and, its yeast counterpart ...
    cd16268
    Location:239337
    EF2_II; Domain II of Elongation Factor 2
    cd16261
    Location:353424
    EF2_snRNP_III; Domain III of Elongation Factor 2 (EF2)
  2. XM_024450048.1XP_024305816.1  elongation factor-like GTPase 1 isoform X2

    Conserved Domains (1) summary
    cl27769
    Location:29567
    GTP_EFTU; Elongation factor Tu GTP binding domain
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