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OGFRL1 opioid growth factor receptor like 1 [ Homo sapiens (human) ]

Gene ID: 79627, updated on 12-Aug-2022

Summary

Official Symbol
OGFRL1provided by HGNC
Official Full Name
opioid growth factor receptor like 1provided by HGNC
Primary source
HGNC:HGNC:21378
See related
Ensembl:ENSG00000119900 AllianceGenome:HGNC:21378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ331H24.1
Summary
Predicted to enable opioid growth factor receptor activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 22.5), esophagus (RPKM 15.1) and 24 other tissues See more
Orthologs
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Genomic context

See OGFRL1 in Genome Data Viewer
Location:
6q13
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (71288811..71309059)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (72469249..72489496)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (71998514..72018762)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901338 Neighboring gene uncharacterized LOC124901339 Neighboring gene coiled-coil domain containing 112 pseudogene Neighboring gene origin of replication 343 Neighboring gene microRNA 30c-2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21079, MGC102783

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables opioid growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
opioid growth factor receptor-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324266.2NP_001311195.1  opioid growth factor receptor-like protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AI800853, AK124833, AK308623, AL137346, BC018688, BX379107, BX420584, BX488500, CK819012, DA151056, DA330565, DA852679
    UniProtKB/Swiss-Prot
    Q5TC84
    Conserved Domains (2) summary
    pfam04664
    Location:114320
    OGFr_N; Opioid growth factor receptor (OGFr) conserved region
    cl15483
    Location:254434
    Hid1; High-temperature-induced dauer-formation protein
  2. NM_024576.5NP_078852.3  opioid growth factor receptor-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_078852.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AI800853, AK124833, AK308623, AL137346, BC018688, BX488500, CK819012, DA151056, DA330565, DA852679
    Consensus CDS
    CCDS34482.1
    UniProtKB/Swiss-Prot
    Q5TC84, Q9H7B5
    Related
    ENSP00000359464.3, ENST00000370435.5
    Conserved Domains (2) summary
    pfam04664
    Location:113319
    OGFr_N; Opioid growth factor receptor (OGFr) conserved region
    cl15483
    Location:253433
    Hid1; High-temperature-induced dauer-formation protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    71288811..71309059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419365.1XP_047275321.1  opioid growth factor receptor-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A3B3IRI0
    Related
    ENSP00000496790.1, ENST00000650315.1
  2. XM_017011305.3XP_016866794.1  opioid growth factor receptor-like protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    72469249..72489496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)