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NDNF neuron derived neurotrophic factor [ Homo sapiens (human) ]

Gene ID: 79625, updated on 11-Jun-2021

Summary

Official Symbol
NDNFprovided by HGNC
Official Full Name
neuron derived neurotrophic factorprovided by HGNC
Primary source
HGNC:HGNC:26256
See related
Ensembl:ENSG00000173376 MIM:616506
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HH25; NORD; C4orf31
Expression
Biased expression in lung (RPKM 64.4), placenta (RPKM 31.0) and 9 other tissues See more
Orthologs
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Genomic context

See NDNF in Genome Data Viewer
Location:
4q27
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (121029293..121072535, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (121956768..121993690, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene PR/SET domain 5 Neighboring gene uncharacterized LOC105377399 Neighboring gene SET pseudogene 12 Neighboring gene RN7SK pseudogene 137 Neighboring gene NDNF antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 6302 Neighboring gene TNFAIP3 interacting protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of neuron-derived neurotrophic factor (NDNF; C4orf31) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycosaminoglycan binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to fibroblast growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular matrix organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gonadotrophin-releasing hormone neuronal migration to the hypothalamus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nitric oxide mediated signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to ischemia IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein NDNF
Names
fibronectin type-III domain-containing protein C4orf31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024574.4NP_078850.3  protein NDNF precursor

    See identical proteins and their annotated locations for NP_078850.3

    Status: VALIDATED

    Source sequence(s)
    AC105254, AK026844, AY358821, BC019351, BX359842, DA807168
    Consensus CDS
    CCDS3717.2
    UniProtKB/Swiss-Prot
    Q8TB73
    Related
    ENSP00000369014.4, ENST00000379692.9
    Conserved Domains (1) summary
    pfam10179
    Location:291383
    DUF2369; Uncharacterized conserved protein (DUF2369)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    121029293..121072535 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454213.1XP_024309981.1  protein NDNF isoform X1

    Conserved Domains (1) summary
    pfam10179
    Location:291383
    DUF2369; Uncharacterized conserved protein (DUF2369)
  2. XM_024454212.1XP_024309980.1  protein NDNF isoform X1

    Conserved Domains (1) summary
    pfam10179
    Location:291383
    DUF2369; Uncharacterized conserved protein (DUF2369)
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