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MRPL24 mitochondrial ribosomal protein L24 [ Homo sapiens (human) ]

Gene ID: 79590, updated on 9-Jun-2025
Official Symbol
MRPL24provided by HGNC
Official Full Name
mitochondrial ribosomal protein L24provided by HGNC
Primary source
HGNC:HGNC:14037
See related
Ensembl:ENSG00000143314 MIM:611836; AllianceGenome:HGNC:14037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L24mt; uL24m; MRP-L18; MRP-L24
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 29.6), adrenal (RPKM 28.7) and 25 other tissues See more
Orthologs
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See MRPL24 in Genome Data Viewer
Location:
1q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156737303..156742716, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155874136..155878130, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156707095..156710880, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156674429-156674930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156676520-156677196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156677875-156678551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156682885-156683400 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1434 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene methyltransferase like 25B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156711011-156711988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717051-156717748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717749-156718446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156718447-156719143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156721068-156721842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156729657-156730190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156730191-156730723 Neighboring gene heparin binding growth factor Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156736100-156736726 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156736727-156737352 Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene Sharpr-MPRA regulatory region 3718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156774267-156774768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156778787-156779288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156783176-156783722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1438 Neighboring gene SH2 domain containing 2A Neighboring gene neurotrophic receptor tyrosine kinase 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Mammalian mitochondrial ribosomal proteins (4). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 2000 Jun 16. PMID 10751423
  2. GRSF1 regulates RNA processing in mitochondrial RNA granules. Jourdain AA, et al. Cell Metab, 2013 Mar 5. PMID 23473034, Free PMC Article
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634
  4. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  5. TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment. Tian X, et al. Biochim Biophys Acta Mol Cell Res, 2023 Oct. PMID 37506885

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Replication interactions

Interaction Pubs
Knockdown of mitochondrial ribosomal protein L24 (MRPL24) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9831, FLJ20917, MGC22737

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
large ribosomal subunit protein uL24m
Names
39S ribosomal protein L24, mitochondrial
mitochondrial large ribosomal subunit protein uL24m

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024540.4 → NP_078816.2  large ribosomal subunit protein uL24m

    See identical proteins and their annotated locations for NP_078816.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. It encodes the same protein as variant 1.
    Source sequence(s)
    AA730909, BC012440
    Consensus CDS
    CCDS1155.1
    UniProtKB/Swiss-Prot
    D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
    UniProtKB/TrEMBL
    X6RJ73
    Related
    ENSP00000357194.4, ENST00000368211.8
    Conserved Domains (1) summary
    cd06089
    Location:59 → 122
    KOW_RPL26; KOW motif of Ribosomal Protein L26

  2. NM_145729.3 → NP_663781.1  large ribosomal subunit protein uL24m

    See identical proteins and their annotated locations for NP_663781.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the same protein as variant 2.
    Source sequence(s)
    AA730909, BC016700, BG706700
    Consensus CDS
    CCDS1155.1
    UniProtKB/Swiss-Prot
    D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
    UniProtKB/TrEMBL
    X6RJ73
    Related
    ENSP00000354525.2, ENST00000361531.6
    Conserved Domains (1) summary
    cd06089
    Location:59 → 122
    KOW_RPL26; KOW motif of Ribosomal Protein L26

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    156737303..156742716 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509982.3 → XP_011508284.1  large ribosomal subunit protein uL24m isoform X1

    See identical proteins and their annotated locations for XP_011508284.1

    UniProtKB/Swiss-Prot
    D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
    UniProtKB/TrEMBL
    X6RJ73
    Conserved Domains (1) summary
    cd06089
    Location:59 → 122
    KOW_RPL26; KOW motif of Ribosomal Protein L26

  2. XM_011509981.3 → XP_011508283.1  large ribosomal subunit protein uL24m isoform X1

    See identical proteins and their annotated locations for XP_011508283.1

    UniProtKB/Swiss-Prot
    D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
    UniProtKB/TrEMBL
    X6RJ73
    Conserved Domains (1) summary
    cd06089
    Location:59 → 122
    KOW_RPL26; KOW motif of Ribosomal Protein L26

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    155874136..155878130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338733.1 → XP_054194708.1  large ribosomal subunit protein uL24m isoform X1

    UniProtKB/Swiss-Prot
    D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
    UniProtKB/TrEMBL
    X6RJ73

  2. XM_054338732.1 → XP_054194707.1  large ribosomal subunit protein uL24m isoform X1

    UniProtKB/Swiss-Prot
    D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
    UniProtKB/TrEMBL
    X6RJ73
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A35.1 GenPept UniProtKB/Swiss-Prot:Q96A35

Gene LinkOut

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