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MRPL24 mitochondrial ribosomal protein L24 [ Homo sapiens (human) ]

Gene ID: 79590, updated on 9-Dec-2018

Summary

Official Symbol
MRPL24provided by HGNC
Official Full Name
mitochondrial ribosomal protein L24provided by HGNC
Primary source
HGNC:HGNC:14037
See related
Ensembl:ENSG00000143314 MIM:611836
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L24mt; MRP-L18; MRP-L24
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in fat (RPKM 29.6), adrenal (RPKM 28.7) and 25 other tissues See more
Orthologs

Genomic context

See MRPL24 in Genome Data Viewer
Location:
1q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (156737302..156741267, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156707094..156710923, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene ribosomal RNA adenine dimethylase domain containing 1 Neighboring gene heparin binding growth factor Neighboring gene proline rich mitotic checkpoint control factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of mitochondrial ribosomal protein L24 (MRPL24) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Ribosome, organism-specific biosystem (from KEGG)
    Ribosome, organism-specific biosystem
    Ribosome
  • Ribosome, conserved biosystem (from KEGG)
    Ribosome, conserved biosystem
    Ribosome

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9831, FLJ20917, MGC22737

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L24, mitochondrial
Names
mitochondrial large ribosomal subunit protein uL24m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024540.3NP_078816.2  39S ribosomal protein L24, mitochondrial

    See identical proteins and their annotated locations for NP_078816.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. It encodes the same protein as variant 1.
    Source sequence(s)
    AA730909, BC012440, BG706700
    Consensus CDS
    CCDS1155.1
    UniProtKB/Swiss-Prot
    Q96A35
    Related
    ENSP00000357194.4, ENST00000368211.8
    Conserved Domains (1) summary
    cd06089
    Location:59122
    KOW_RPL26; KOW motif of Ribosomal Protein L26
  2. NM_145729.3NP_663781.1  39S ribosomal protein L24, mitochondrial

    See identical proteins and their annotated locations for NP_663781.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it encodes the same protein as variant 2.
    Source sequence(s)
    AA730909, BC016700, BG706700
    Consensus CDS
    CCDS1155.1
    UniProtKB/Swiss-Prot
    Q96A35
    Related
    ENSP00000354525.2, ENST00000361531.6
    Conserved Domains (1) summary
    cd06089
    Location:59122
    KOW_RPL26; KOW motif of Ribosomal Protein L26

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    156737302..156741267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509982.2XP_011508284.1  39S ribosomal protein L24, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011508284.1

    UniProtKB/Swiss-Prot
    Q96A35
    Conserved Domains (1) summary
    cd06089
    Location:59122
    KOW_RPL26; KOW motif of Ribosomal Protein L26
  2. XM_011509981.2XP_011508283.1  39S ribosomal protein L24, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011508283.1

    UniProtKB/Swiss-Prot
    Q96A35
    Conserved Domains (1) summary
    cd06089
    Location:59122
    KOW_RPL26; KOW motif of Ribosomal Protein L26
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