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CHPF chondroitin polymerizing factor [ Homo sapiens (human) ]

Gene ID: 79586, updated on 7-Jun-2020

Summary

Official Symbol
CHPFprovided by HGNC
Official Full Name
chondroitin polymerizing factorprovided by HGNC
Primary source
HGNC:HGNC:24291
See related
Ensembl:ENSG00000123989 MIM:610405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSS2; CHSY2
Expression
Broad expression in testis (RPKM 33.7), placenta (RPKM 25.6) and 24 other tissues See more
Orthologs

Genomic context

See CHPF in Genome Data Viewer
Location:
2q35
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (219538947..219543809, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220403669..220408487, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ASIC4 antisense RNA 1 Neighboring gene GATA motif-containing MPRA enhancer 279/280 Neighboring gene acid sensing ion channel subunit family member 4 Neighboring gene transmembrane protein 198 Neighboring gene microRNA 3132 Neighboring gene obscurin like cytoskeletal adaptor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22678

Gene Ontology Provided by GOA

Process Evidence Code Pubs
chondroitin sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
cytosol IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chondroitin sulfate synthase 2
Names
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
N-acetylgalactosaminyltransferase 2
chondroitin glucuronyltransferase 2
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
NP_001182660.1
NP_078812.3
XP_011510140.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195731.1NP_001182660.1  chondroitin sulfate synthase 2 isoform 2

    See identical proteins and their annotated locations for NP_001182660.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1, resulting in translation initiation from an in-frame downstream AUG, and an isoform (2) with a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AB086063, AK302124, BC021223, DC341343
    Consensus CDS
    CCDS56169.1
    UniProtKB/Swiss-Prot
    Q8IZ52
    Related
    ENSP00000445571.1, ENST00000535926.2
    Conserved Domains (2) summary
    pfam05679
    Location:100600
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:32142
    Galactosyl_T; Galactosyltransferase
  2. NM_024536.6NP_078812.3  chondroitin sulfate synthase 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC009955
    Consensus CDS
    CCDS2443.1
    Related
    ENSP00000243776.6, ENST00000243776.11
    Conserved Domains (2) summary
    pfam05679
    Location:262762
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:194304
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    219538947..219543809 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511838.3XP_011510140.1  chondroitin sulfate synthase 2 isoform X1

    Conserved Domains (1) summary
    pfam05679
    Location:3471
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
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