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Chpf chondroitin polymerizing factor [ Mus musculus (house mouse) ]

Gene ID: 74241, updated on 18-Apr-2024

Summary

Official Symbol
Chpfprovided by MGI
Official Full Name
chondroitin polymerizing factorprovided by MGI
Primary source
MGI:MGI:106576
See related
Ensembl:ENSMUSG00000032997 AllianceGenome:MGI:106576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Bwg1363e; 1700028N03Rik
Summary
Enables glycosyltransferase activity. Acts upstream of or within chondroitin sulfate biosynthetic process. Predicted to be located in Golgi cisterna membrane and mitochondrion. Predicted to be integral component of membrane. Orthologous to human CHPF (chondroitin polymerizing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 121.4), adrenal adult (RPKM 100.6) and 24 other tissues See more
Orthologs
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Genomic context

Location:
1 C4; 1 39.14 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75451213..75456115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75474569..75479471, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene GDP-mannose pyrophosphorylase A Neighboring gene STARR-seq mESC enhancer starr_01359 Neighboring gene predicted gene, 53564 Neighboring gene acid-sensing ion channel family member 4 Neighboring gene predicted gene, 32506 Neighboring gene STARR-positive B cell enhancer ABC_E1997 Neighboring gene transmembrane protein 198 Neighboring gene obscurin-like 1 Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene inhibin alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chondroitin sulfate synthase 2
Names
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase II
N-acetylgalactosaminyltransferase 2
chondroitin glucuronyltransferase 2
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
NP_001001565.1
NP_001001566.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001565.2NP_001001565.1  chondroitin sulfate synthase 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the coding region and uses a downstream AUG compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC115011, BB651806, BC060598, BC071273
    Consensus CDS
    CCDS15075.1
    UniProtKB/Swiss-Prot
    Q6IQX7
    Related
    ENSMUSP00000092412.3, ENSMUST00000094818.4
    Conserved Domains (2) summary
    pfam05679
    Location:100599
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:32121
    Galactosyl_T; Galactosyltransferase
  2. NM_001001566.3NP_001001566.1  chondroitin sulfate synthase 2 isoform a

    See identical proteins and their annotated locations for NP_001001566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC115011, BC071273
    Consensus CDS
    CCDS15074.1
    UniProtKB/Swiss-Prot
    E9PUB9, Q6IQX7
    Related
    ENSMUSP00000078199.8, ENSMUST00000079205.14
    Conserved Domains (2) summary
    pfam05679
    Location:262761
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:194283
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75451213..75456115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)