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RIPOR1 RHO family interacting cell polarization regulator 1 [ Homo sapiens (human) ]

Gene ID: 79567, updated on 16-Oct-2021

Summary

Official Symbol
RIPOR1provided by HGNC
Official Full Name
RHO family interacting cell polarization regulator 1provided by HGNC
Primary source
HGNC:HGNC:25836
See related
Ensembl:ENSG00000039523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM65A
Expression
Ubiquitous expression in spleen (RPKM 22.0), lung (RPKM 16.7) and 25 other tissues See more
Orthologs
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Genomic context

See RIPOR1 in Genome Data Viewer
Location:
16q22.1
Exon count:
26
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67518423..67546786)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67562732..67580689)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit d1 Neighboring gene ATP6V0D1 divergent transcript Neighboring gene agouti related neuropeptide Neighboring gene uncharacterized LOC100505942 Neighboring gene CTCF divergent transcript Neighboring gene CCCTC-binding factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13725, KIAA1930

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
rho family-interacting cell polarization regulator 1
Names
family with sequence similarity 65 member A
protein FAM65A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193522.2NP_001180451.1  rho family-interacting cell polarization regulator 1 isoform 2

    See identical proteins and their annotated locations for NP_001180451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) has an additional segment in the N-terminal region, as compared to isoform 1.
    Source sequence(s)
    AK127792, BC098587
    Consensus CDS
    CCDS54028.1
    UniProtKB/Swiss-Prot
    Q6ZS17
    Related
    ENSP00000368614.3, ENST00000379312.7
    Conserved Domains (3) summary
    pfam13646
    Location:11261189
    HEAT_2; HEAT repeats
    pfam15903
    Location:17369
    PL48; Filopodia upregulated, FAM65
    sd00044
    Location:10971127
    HEAT; HEAT repeat [structural motif]
  2. NM_001193523.2NP_001180452.1  rho family-interacting cell polarization regulator 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, which includes an upstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (3) is the longest, and has a longer N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC027682, AK127792, AK293748, BC098587, DC310605
    Consensus CDS
    CCDS54026.1
    UniProtKB/Swiss-Prot
    Q6ZS17
    Related
    ENSP00000400099.2, ENST00000422602.8
    Conserved Domains (3) summary
    pfam13646
    Location:11421205
    HEAT_2; HEAT repeats
    pfam15903
    Location:37385
    PL48; Filopodia upregulated, FAM65
    sd00044
    Location:11131143
    HEAT; HEAT repeat [structural motif]
  3. NM_001193524.2NP_001180453.1  rho family-interacting cell polarization regulator 1 isoform 4

    See identical proteins and their annotated locations for NP_001180453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, which includes an upstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (4) has a longer N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK295677, BC098587, DC422629
    Consensus CDS
    CCDS54027.1
    UniProtKB/Swiss-Prot
    Q6ZS17
    Related
    ENSP00000389456.2, ENST00000428437.6
    Conserved Domains (3) summary
    pfam13646
    Location:11361199
    HEAT_2; HEAT repeats
    pfam15903
    Location:31379
    PL48; Filopodia upregulated, FAM65
    sd00044
    Location:11071137
    HEAT; HEAT repeat [structural motif]
  4. NM_024519.4NP_078795.2  rho family-interacting cell polarization regulator 1 isoform 1

    See identical proteins and their annotated locations for NP_078795.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shortest but dominant isoform (1).
    Source sequence(s)
    BC098587, CN401995
    Consensus CDS
    CCDS10840.1
    UniProtKB/Swiss-Prot
    Q6ZS17
    Related
    ENSP00000042381.4, ENST00000042381.9
    Conserved Domains (5) summary
    sd00044
    Location:10931123
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:11281185
    HEAT_2; HEAT repeats
    pfam15903
    Location:17365
    PL48; Filopodia upregulated, FAM65
    cl25496
    Location:417605
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl26464
    Location:392929
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67518423..67546786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450442.1XP_024306210.1  rho family-interacting cell polarization regulator 1 isoform X5

    Conserved Domains (5) summary
    sd00044
    Location:11021132
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:11371194
    HEAT_2; HEAT repeats
    pfam15903
    Location:17374
    PL48; Filopodia upregulated, FAM65
    cl25496
    Location:426614
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl26464
    Location:401938
    Atrophin-1; Atrophin-1 family
  2. XM_011523325.2XP_011521627.1  rho family-interacting cell polarization regulator 1 isoform X5

    See identical proteins and their annotated locations for XP_011521627.1

    Conserved Domains (5) summary
    sd00044
    Location:11021132
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:11371194
    HEAT_2; HEAT repeats
    pfam15903
    Location:17374
    PL48; Filopodia upregulated, FAM65
    cl25496
    Location:426614
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl26464
    Location:401938
    Atrophin-1; Atrophin-1 family
  3. XM_017023664.2XP_016879153.1  rho family-interacting cell polarization regulator 1 isoform X7

  4. XM_024450443.1XP_024306211.1  rho family-interacting cell polarization regulator 1 isoform X6

    Conserved Domains (5) summary
    sd00044
    Location:10931123
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:11281185
    HEAT_2; HEAT repeats
    pfam15903
    Location:17365
    PL48; Filopodia upregulated, FAM65
    cl25496
    Location:417605
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl26464
    Location:392929
    Atrophin-1; Atrophin-1 family
  5. XM_011523321.1XP_011521623.1  rho family-interacting cell polarization regulator 1 isoform X2

    Conserved Domains (3) summary
    pfam13646
    Location:11511214
    HEAT_2; HEAT repeats
    pfam15903
    Location:37394
    PL48; Filopodia upregulated, FAM65
    sd00044
    Location:11221152
    HEAT; HEAT repeat [structural motif]
  6. XM_011523326.1XP_011521628.1  rho family-interacting cell polarization regulator 1 isoform X5

    See identical proteins and their annotated locations for XP_011521628.1

    Conserved Domains (5) summary
    sd00044
    Location:11021132
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:11371194
    HEAT_2; HEAT repeats
    pfam15903
    Location:17374
    PL48; Filopodia upregulated, FAM65
    cl25496
    Location:426614
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl26464
    Location:401938
    Atrophin-1; Atrophin-1 family
  7. XM_011523322.1XP_011521624.1  rho family-interacting cell polarization regulator 1 isoform X1

    Conserved Domains (3) summary
    pfam13646
    Location:11511214
    HEAT_2; HEAT repeats
    pfam15903
    Location:37394
    PL48; Filopodia upregulated, FAM65
    sd00044
    Location:11221152
    HEAT; HEAT repeat [structural motif]
  8. XM_017023663.1XP_016879152.1  rho family-interacting cell polarization regulator 1 isoform X3

    Conserved Domains (4) summary
    PHA03247
    Location:421957
    PHA03247; large tegument protein UL36; Provisional
    pfam05109
    Location:446634
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00044
    Location:11211151
    HEAT; HEAT repeat [structural motif]
    cl00087
    Location:158225
    HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
  9. XM_011523324.3XP_011521626.1  rho family-interacting cell polarization regulator 1 isoform X4

    Conserved Domains (3) summary
    pfam13646
    Location:11451208
    HEAT_2; HEAT repeats
    pfam15903
    Location:31388
    PL48; Filopodia upregulated, FAM65
    sd00044
    Location:11161146
    HEAT; HEAT repeat [structural motif]
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