LST1 leukocyte specific transcript 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LST1provided by HGNC
Official Full Name: leukocyte specific transcript 1provided by HGNC
Primary source: HGNC:HGNC:14189
See related: Ensembl:ENSG00000204482 MIM:109170; AllianceGenome:HGNC:14189
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: B144; LST-1; D6S49E
Summary: The protein encoded by this gene is a membrane protein that can inhibit the proliferation of lymphocytes. Expression of this gene is enhanced by lipopolysaccharide, interferon-gamma, and bacteria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression: Biased expression in bone marrow (RPKM 68.1), spleen (RPKM 43.9) and 13 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (31586277..31588909)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (31439327..31441957)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (31554054..31556686)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Significance of leukocyte-specific transcript 1 levels in nasal mucosal tissue to predict recurrence of nasal polyps.
Title: Significance of leukocyte-specific transcript 1 levels in nasal mucosal tissue to predict recurrence of nasal polyps.
the present review describes LST1 promotor, gene organization, splice variants and expression in human tissues, cell lines and cancer with the focus on LST1 expression in inflammation, autoimmune diseases and cancer
Title: LST1: A multifunctional gene encoded in the MHC class III region.
Increased expression of LST1 in GC-responders before therapy warrants further investigation into their role as potential predictors for the response to GC, and in the inflammatory process of rheumatoid arthritis.
Title: Expression of ERAP2 and LST1 is increased before start of therapy in rheumatoid arthritis patients with good clinical response to glucocorticoids.
Data indicate that the MHC class III gene LST1 5' untranslated regions (5'-UTR) contains several upstream open reading frames (uORFs).
Title: An upstream open reading frame regulates LST1 expression during monocyte differentiation.
Psoriasis was associated with promoter variant, rs9267502 of LST1.Promoter activity was examined and it was larger than that of the other genetic variants, most probably due to changes in binding affinity to transcription factors.
Title: Identification of functional haplotypes in the promoter region of the LST1 gene.
This is the first report demonstrating regulated LST1 expression in human intestinal epithelial and microvascular endothelial cells and in inflamed colonic tissue from IBD patients.
Title: Regulated expression of leukocyte-specific transcript (LST) 1 in human intestinal inflammation.
induces the formation of functional nanotubes
Title: LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation.
LST1 is expressed specifically in leukocytes of the myeloid lineage, where it localizes to the tetraspanin-enriched microdomains andit binds SHP-1 and SHP-2 phosphatases.
Title: LST1/A is a myeloid leukocyte-specific transmembrane adaptor protein recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to the plasma membrane.
Study found association between extended LTA, TNF, LST1 and HLA gene haplotypes and rubella vaccine-induced immunity.
Title: Extended LTA, TNF, LST1 and HLA gene haplotypes and their association with rubella vaccine-induced immunity.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH76316 (e-PCR)
- UniSTS:92938

NoName (e-PCR)
- UniSTS:481830

NoName (e-PCR)
- UniSTS:482887

TNFd (e-PCR)
- UniSTS:256848

TNFd (e-PCR)
- UniSTS:256849

TNFe (e-PCR)
- UniSTS:515954

RH76281 (e-PCR)
- UniSTS:86153

D6S2790 (e-PCR)
- UniSTS:464287

D6S2789 (e-PCR)
- UniSTS:464288

SHGC-63639 (e-PCR)
- UniSTS:58789

STS-U00921 (e-PCR)
- UniSTS:45518

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dendrite development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in dendrite development	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of lymphocyte proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	NAS Non-traceable Author Statement more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: leukocyte-specific transcript 1 protein

Names: lymphocyte antigen 117

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030378.1 RefSeqGene

Range

5099..7731

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001166538.1 → NP_001160010.1 leukocyte-specific transcript 1 protein isoform 6

See identical proteins and their annotated locations for NP_001160010.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (6) that is shorter than isoform 1. The 5' UTR of this variant is incomplete because the transcripts supporting this CDS exon combination lack a complete 5' UTR, and alternative splicing choices exist further upstream.

Source sequence(s)

AI091696, Y18486

Consensus CDS

CCDS54987.1

UniProtKB/Swiss-Prot

O00453

Related

ENSP00000365254.3, ENST00000376086.7

Conserved Domains (1) summary

pfam05083
Location:7 → 72

LST1; LST-1 protein
NM_007161.3 → NP_009092.3 leukocyte-specific transcript 1 protein isoform 1

See identical proteins and their annotated locations for NP_009092.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). The 5' UTR of this variant is incomplete because the transcripts supporting this CDS exon combination lack a complete 5' UTR, and alternative splicing choices exist further upstream.

Source sequence(s)

AI091696, AL662801, AV715235, AY852266

Consensus CDS

CCDS54984.1

UniProtKB/Swiss-Prot

O00453

Related

ENSP00000365261.2, ENST00000376093.6

Conserved Domains (1) summary

pfam05083
Location:28 → 103

LST1; LST-1 protein
NM_205837.3 → NP_995309.2 leukocyte-specific transcript 1 protein isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) includes an additional exon in the 5' UTR and lacks an internal exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AF000424, AI091696

Consensus CDS

CCDS54985.1

UniProtKB/Swiss-Prot

O00453

Related

ENSP00000339201.4, ENST00000339530.8
NM_205838.3 → NP_995310.2 leukocyte-specific transcript 1 protein isoform 3

See identical proteins and their annotated locations for NP_995310.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) includes an additional exon in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AI091696, AV715235

Consensus CDS

CCDS4705.2

UniProtKB/Swiss-Prot

O00453

Related

ENSP00000405900.2, ENST00000418507.6

Conserved Domains (1) summary

pfam05083
Location:7 → 65

LST1; LST-1 protein
NM_205839.3 → NP_995311.2 leukocyte-specific transcript 1 protein isoform 4

See identical proteins and their annotated locations for NP_995311.2

Status: REVIEWED

Description

Transcript Variant: This variant (4) includes an additional exon in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AF000425, AI091696, AL662801

Consensus CDS

CCDS43450.2

UniProtKB/Swiss-Prot

O00453, Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6

Related

ENSP00000391929.3, ENST00000438075.7

Conserved Domains (1) summary

pfam05083
Location:28 → 96

LST1; LST-1 protein
NM_205840.2 → NP_995312.2 leukocyte-specific transcript 1 protein isoform 5

See identical proteins and their annotated locations for NP_995312.2

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate exon in the central coding region and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1. The 5' UTR of this variant is incomplete because the transcripts supporting this CDS exon combination lack a complete 5' UTR, and alternative splicing choices exist further upstream.

Source sequence(s)

AI091696, Y18487

Consensus CDS

CCDS54986.1

UniProtKB/Swiss-Prot

O00453

Related

ENSP00000303649.7, ENST00000303757.12

RNA

NR_029461.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) includes an additional 5' exon, lacks two alternate internal exons, and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding due to uncertainty about its protein-coding capacity; only a very short protein would result from translation initiation at the supported start codon, as used by variant 1.

Source sequence(s)

AI091696, AJ705986

Related

ENST00000376099.5
NR_029462.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) includes an additional 5' exon, lacks two alternate internal exons, and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding due to uncertainty about its protein-coding capacity; only a very short protein would result from translation initiation at the supported start codon, as used by variant 1.

Source sequence(s)

AI091696, AV711621

Related

ENST00000376096.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

31586277..31588909

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006715206.4 → XP_006715269.1 leukocyte-specific transcript 1 protein isoform X1

See identical proteins and their annotated locations for XP_006715269.1

UniProtKB/Swiss-Prot

O00453

Conserved Domains (1) summary

pfam05083
Location:28 → 103

LST1; LST-1 protein
XM_006715210.4 → XP_006715273.1 leukocyte-specific transcript 1 protein isoform X4

See identical proteins and their annotated locations for XP_006715273.1

UniProtKB/Swiss-Prot

O00453
XM_006715209.4 → XP_006715272.1 leukocyte-specific transcript 1 protein isoform X3

See identical proteins and their annotated locations for XP_006715272.1

UniProtKB/Swiss-Prot

O00453

Conserved Domains (1) summary

pfam05083
Location:7 → 72

LST1; LST-1 protein
XM_011514914.3 → XP_011513216.1 leukocyte-specific transcript 1 protein isoform X1

See identical proteins and their annotated locations for XP_011513216.1

UniProtKB/Swiss-Prot

O00453

Conserved Domains (1) summary

pfam05083
Location:28 → 103

LST1; LST-1 protein
XM_047419357.1 → XP_047275313.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

Range

2918856..2921488

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054328518.1 → XP_054184493.1 leukocyte-specific transcript 1 protein isoform X1
XM_054328522.1 → XP_054184497.1 leukocyte-specific transcript 1 protein isoform X4
XM_054328521.1 → XP_054184496.1 leukocyte-specific transcript 1 protein isoform X3
XM_054328519.1 → XP_054184494.1 leukocyte-specific transcript 1 protein isoform X1
XM_054328520.1 → XP_054184495.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

Range

3063564..3066192

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054329908.1 → XP_054185883.1 leukocyte-specific transcript 1 protein isoform X1
XM_054329913.1 → XP_054185888.1 leukocyte-specific transcript 1 protein isoform X4
XM_054329912.1 → XP_054185887.1 leukocyte-specific transcript 1 protein isoform X3
XM_054329909.1 → XP_054185884.1 leukocyte-specific transcript 1 protein isoform X1
XM_054329910.1 → XP_054185885.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6
XM_054329911.1 → XP_054185886.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

Range

2834012..2836646

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330400.1 → XP_054186375.1 leukocyte-specific transcript 1 protein isoform X1
XM_054330405.1 → XP_054186380.1 leukocyte-specific transcript 1 protein isoform X4
XM_054330404.1 → XP_054186379.1 leukocyte-specific transcript 1 protein isoform X3
XM_054330401.1 → XP_054186376.1 leukocyte-specific transcript 1 protein isoform X1
XM_054330402.1 → XP_054186377.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6
XM_054330403.1 → XP_054186378.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

Range

2891318..2893950

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330680.1 → XP_054186655.1 leukocyte-specific transcript 1 protein isoform X1
XM_054330684.1 → XP_054186659.1 leukocyte-specific transcript 1 protein isoform X4
XM_054330683.1 → XP_054186658.1 leukocyte-specific transcript 1 protein isoform X3
XM_054330681.1 → XP_054186656.1 leukocyte-specific transcript 1 protein isoform X1
XM_054330682.1 → XP_054186657.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

Range

2928172..2930802

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054330892.1 → XP_054186867.1 leukocyte-specific transcript 1 protein isoform X1
XM_054330898.1 → XP_054186873.1 leukocyte-specific transcript 1 protein isoform X4
XM_054330897.1 → XP_054186872.1 leukocyte-specific transcript 1 protein isoform X3
XM_054330893.1 → XP_054186868.1 leukocyte-specific transcript 1 protein isoform X1
XM_054330895.1 → XP_054186870.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6
XM_054330894.1 → XP_054186869.1 leukocyte-specific transcript 1 protein isoform X1
XM_054330896.1 → XP_054186871.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

Range

2842098..2844732

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331176.1 → XP_054187151.1 leukocyte-specific transcript 1 protein isoform X1
XM_054331181.1 → XP_054187156.1 leukocyte-specific transcript 1 protein isoform X4
XM_054331180.1 → XP_054187155.1 leukocyte-specific transcript 1 protein isoform X3
XM_054331177.1 → XP_054187152.1 leukocyte-specific transcript 1 protein isoform X1
XM_054331178.1 → XP_054187153.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6
XM_054331179.1 → XP_054187154.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

2885558..2888190

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331415.1 → XP_054187390.1 leukocyte-specific transcript 1 protein isoform X1
XM_054331418.1 → XP_054187393.1 leukocyte-specific transcript 1 protein isoform X4
XM_054331417.1 → XP_054187392.1 leukocyte-specific transcript 1 protein isoform X3
XM_054331416.1 → XP_054187391.1 leukocyte-specific transcript 1 protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

31439327..31441957

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356412.1 → XP_054212387.1 leukocyte-specific transcript 1 protein isoform X1
XM_054356418.1 → XP_054212393.1 leukocyte-specific transcript 1 protein isoform X4
XM_054356417.1 → XP_054212392.1 leukocyte-specific transcript 1 protein isoform X3
XM_054356413.1 → XP_054212388.1 leukocyte-specific transcript 1 protein isoform X1
XM_054356415.1 → XP_054212390.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6
XM_054356414.1 → XP_054212389.1 leukocyte-specific transcript 1 protein isoform X1
XM_054356416.1 → XP_054212391.1 leukocyte-specific transcript 1 protein isoform X2

UniProtKB/Swiss-Prot

Q9UJS1

UniProtKB/TrEMBL

A0A024RCT6