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SLC39A7 solute carrier family 39 member 7 [ Homo sapiens (human) ]

Gene ID: 7922, updated on 4-Oct-2020

Summary

Official Symbol
SLC39A7provided by HGNC
Official Full Name
solute carrier family 39 member 7provided by HGNC
Primary source
HGNC:HGNC:4927
See related
Ensembl:ENSG00000112473 MIM:601416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KE4; HKE4; ZIP7; RING5; H2-KE4; D6S115E; D6S2244E
Summary
The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in prostate (RPKM 58.8), placenta (RPKM 52.4) and 25 other tissues See more
Orthologs

Genomic context

See SLC39A7 in Genome Data Viewer
Location:
6p21.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (33200867..33204437)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33168603..33172214)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene collagen type XI alpha 2 chain Neighboring gene retinoid X receptor beta Neighboring gene RNY4 pseudogene 10 Neighboring gene hydroxysteroid 17-beta dehydrogenase 8 Neighboring gene microRNA 219a-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
cellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc transporter SLC39A7
Names
HLA class II region expressed gene KE4
Ke4 gene, mouse, human homolog of
histidine-rich membrane protein Ke4
really interesting new gene 5 protein
solute carrier family 39 (zinc transporter), member 7
zrt-, Irt-like protein 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077516.2NP_001070984.1  zinc transporter SLC39A7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001070984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    BC000645, DA573310
    Consensus CDS
    CCDS43453.1
    UniProtKB/Swiss-Prot
    Q92504
    UniProtKB/TrEMBL
    A0A024RCX7
    Related
    ENSP00000363807.3, ENST00000374675.7
    Conserved Domains (1) summary
    pfam02535
    Location:132446
    Zip; ZIP Zinc transporter
  2. NM_001288777.2NP_001275706.1  zinc transporter SLC39A7 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which contains a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK303158, BC000645
    UniProtKB/Swiss-Prot
    Q92504
    UniProtKB/TrEMBL
    B4DZZ8
    Conserved Domains (1) summary
    pfam02535
    Location:16321
    Zip; ZIP Zinc transporter
  3. NM_006979.3NP_008910.2  zinc transporter SLC39A7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_008910.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000645, DA573310, DR158641
    Consensus CDS
    CCDS43453.1
    UniProtKB/Swiss-Prot
    Q92504
    UniProtKB/TrEMBL
    A0A024RCX7
    Related
    ENSP00000363809.3, ENST00000374677.8
    Conserved Domains (1) summary
    pfam02535
    Location:132446
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    33200867..33204437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p13 ALT_REF_LOCI_2

    Range
    4612372..4615942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p13 ALT_REF_LOCI_3

    Range
    4444366..4447936
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p13 ALT_REF_LOCI_4

    Range
    4620340..4623910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p13 ALT_REF_LOCI_5

    Range
    4636820..4640390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p13 ALT_REF_LOCI_6

    Range
    4395271..4398841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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