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Slc39a7 solute carrier family 39 (zinc transporter), member 7 [ Mus musculus (house mouse) ]

Gene ID: 14977, updated on 12-May-2024

Summary

Official Symbol
Slc39a7provided by MGI
Official Full Name
solute carrier family 39 (zinc transporter), member 7provided by MGI
Primary source
MGI:MGI:95909
See related
Ensembl:ENSMUSG00000024327 AllianceGenome:MGI:95909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ke4; Ke-4; Zip7; Ring5; H-2Ke4; H2-Ke4
Summary
Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in cellular zinc ion homeostasis and zinc ion transmembrane transport. Predicted to act upstream of or within zinc ion transport. Predicted to be located in endoplasmic reticulum and nucleoplasm. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; immune system; and nervous system. Orthologous to human SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 99.5), adrenal adult (RPKM 66.7) and 28 other tissues See more
Orthologs
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Genomic context

See Slc39a7 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34247240..34250664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34028266..34031690, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene microRNA 219a-1 Neighboring gene microRNA 219c Neighboring gene STARR-positive B cell enhancer ABC_E5594 Neighboring gene hydroxysteroid 17-beta dehydrogenase 8 Neighboring gene STARR-positive B cell enhancer ABC_E5595 Neighboring gene retinoid X receptor beta Neighboring gene collagen, type XI, alpha 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC143814, MGC143815

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular zinc ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in metal ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ferroptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in skin epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in zinc ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in zinc ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in zinc ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within zinc ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc transporter SLC39A7
Names
H2-K region expressed gene 4
histidine-rich membrane protein Ke4
solute carrier family 39 member 7
zrt-, Irt-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077709.1NP_001071177.1  zinc transporter SLC39A7 precursor

    See identical proteins and their annotated locations for NP_001071177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA170090, AK159968, AK167344, BY288782
    Consensus CDS
    CCDS37576.1
    UniProtKB/Swiss-Prot
    Q31125, Q3TVU6, Q9Z1W1
    UniProtKB/TrEMBL
    A0A068BIT0, Q14C53
    Related
    ENSMUSP00000130102.2, ENSMUST00000169397.9
    Conserved Domains (1) summary
    pfam02535
    Location:140453
    Zip; ZIP Zinc transporter
  2. NM_008202.2NP_032228.2  zinc transporter SLC39A7 precursor

    See identical proteins and their annotated locations for NP_032228.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA170090, AK159968, AK167344, BY288782
    Consensus CDS
    CCDS37576.1
    UniProtKB/Swiss-Prot
    Q31125, Q3TVU6, Q9Z1W1
    UniProtKB/TrEMBL
    A0A068BIT0, Q14C53
    Related
    ENSMUSP00000025186.9, ENSMUST00000025186.16
    Conserved Domains (1) summary
    pfam02535
    Location:140453
    Zip; ZIP Zinc transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34247240..34250664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)