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RNF26 ring finger protein 26 [ Homo sapiens (human) ]

Gene ID: 79102, updated on 22-Aug-2021

Summary

Official Symbol
RNF26provided by HGNC
Official Full Name
ring finger protein 26provided by HGNC
Primary source
HGNC:HGNC:14646
See related
Ensembl:ENSG00000173456 MIM:606130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See RNF26 in Genome Data Viewer
Location:
11q23.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119334527..119337309)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (119205237..119208019)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene Cbl proto-oncogene Neighboring gene RNA, U6 small nuclear 262, pseudogene Neighboring gene microRNA 6756 Neighboring gene melanoma cell adhesion molecule Neighboring gene C1q and TNF related 5 Neighboring gene membrane frizzled-related protein Neighboring gene HNF4 motif-containing MPRA enhancer 223 Neighboring gene ubiquitin specific peptidase 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ring finger protein 26 (RNF26) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of ring finger protein 26 (RNF26) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2642

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF26
Names
ring finger protein with leucine zipper
NP_114404.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032015.5NP_114404.1  E3 ubiquitin-protein ligase RNF26

    See identical proteins and their annotated locations for NP_114404.1

    Status: REVIEWED

    Source sequence(s)
    AP003396
    Consensus CDS
    CCDS8419.1
    UniProtKB/Swiss-Prot
    Q9BY78
    Related
    ENSP00000312439.4, ENST00000311413.5
    Conserved Domains (1) summary
    cd16788
    Location:378425
    mRING-HC-C3HC5_RNF26; Modified RING finger, HC subclass (C3HC5-type), found in RING finger protein 26 (RNF26) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    119334527..119337309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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