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TMUB2 transmembrane and ubiquitin like domain containing 2 [ Homo sapiens (human) ]

Gene ID: 79089, updated on 6-Nov-2022

Summary

Official Symbol
TMUB2provided by HGNC
Official Full Name
transmembrane and ubiquitin like domain containing 2provided by HGNC
Primary source
HGNC:HGNC:28459
See related
Ensembl:ENSG00000168591 AllianceGenome:HGNC:28459
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FP2653
Summary
Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 16.4), spleen (RPKM 14.8) and 25 other tissues See more
Orthologs
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Genomic context

See TMUB2 in Genome Data Viewer
Location:
17q21.31
Exon count:
7
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (44186972..44191929)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45040074..45045031)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (42264340..42269297)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene homologous recombination factor with OB-fold Neighboring gene ankyrin repeat and SOCS box containing 16 Neighboring gene ASB16 antisense RNA 1 Neighboring gene ataxin 7 like 3 Neighboring gene Sharpr-MPRA regulatory region 8559 Neighboring gene microRNA 6782 Neighboring gene upstream binding transcription factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane and ubiquitin-like domain-containing protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076674.3NP_001070142.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001070142.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate exon with an upstream start codon, compared to variant 1. The resulting protein (isoform b) has a longer N-terminus, compared to isoform a.
    Source sequence(s)
    AC004596, AL533563, AL538440, BI906577, BM999307
    Consensus CDS
    CCDS54134.1
    UniProtKB/Swiss-Prot
    Q71RG4, Q9HAG3
    Related
    ENSP00000444565.1, ENST00000538716.7
    Conserved Domains (1) summary
    pfam00240
    Location:176245
    ubiquitin; Ubiquitin family
  2. NM_001330235.2NP_001317164.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AK294198, BC004306, BM999307
    Consensus CDS
    CCDS82137.1
    UniProtKB/Swiss-Prot
    Q71RG4
    UniProtKB/TrEMBL
    B4DFQ1, E7ESS3
    Related
    ENSP00000413127.2, ENST00000446571.7
    Conserved Domains (1) summary
    pfam00240
    Location:119188
    ubiquitin; Ubiquitin family
  3. NM_001353173.2NP_001340102.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  4. NM_001353174.2NP_001340103.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS82137.1
    UniProtKB/TrEMBL
    E7ESS3
    Conserved Domains (1) summary
    pfam00240
    Location:119188
    ubiquitin; Ubiquitin family
  5. NM_001353175.2NP_001340104.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  6. NM_001353176.2NP_001340105.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  7. NM_001353177.2NP_001340106.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS54134.1
    UniProtKB/Swiss-Prot
    Q9HAG3
    Related
    ENSP00000466971.1, ENST00000587989.1
    Conserved Domains (1) summary
    pfam00240
    Location:176245
    ubiquitin; Ubiquitin family
  8. NM_001353178.2NP_001340107.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  9. NM_001353180.2NP_001340109.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Conserved Domains (1) summary
    cd17132
    Location:164234
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  10. NM_001353181.2NP_001340110.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS54134.1
    UniProtKB/Swiss-Prot
    Q9HAG3
    Conserved Domains (1) summary
    pfam00240
    Location:176245
    ubiquitin; Ubiquitin family
  11. NM_001353182.2NP_001340111.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Related
    ENSP00000467364.1, ENST00000589785.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  12. NM_001353183.2NP_001340112.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  13. NM_001353184.2NP_001340113.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS54134.1
    UniProtKB/Swiss-Prot
    Q9HAG3
    Conserved Domains (1) summary
    pfam00240
    Location:176245
    ubiquitin; Ubiquitin family
  14. NM_001353185.2NP_001340114.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Conserved Domains (1) summary
    pfam00240
    Location:130199
    ubiquitin; Ubiquitin family
  15. NM_001353186.2NP_001340115.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC004596
  16. NM_001353187.2NP_001340116.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Conserved Domains (1) summary
    pfam00240
    Location:130199
    ubiquitin; Ubiquitin family
  17. NM_001353188.2NP_001340117.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  18. NM_001353189.2NP_001340118.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Conserved Domains (1) summary
    cd17132
    Location:164234
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  19. NM_001353190.2NP_001340119.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  20. NM_001353191.2NP_001340120.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Consensus CDS
    CCDS11479.1
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  21. NM_024107.4NP_077012.2  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_077012.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC004596, BC063489, BI906577, BM999307
    Consensus CDS
    CCDS11479.1
    UniProtKB/Swiss-Prot
    Q71RG4
    Related
    ENSP00000350672.3, ENST00000357984.7
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)
  22. NM_177441.4NP_803190.2  transmembrane and ubiquitin-like domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_803190.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC004596, AL833899, BM999307, HY071246
    Consensus CDS
    CCDS11479.1
    UniProtKB/Swiss-Prot
    Q71RG4
    Related
    ENSP00000313214.5, ENST00000319511.6
    Conserved Domains (1) summary
    cd17132
    Location:153223
    Ubl_TMUB2; ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)

RNA

  1. NR_148386.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004596, BC004306, BM999307
    Related
    ENST00000590235.5
  2. NR_148387.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004596
  3. NR_148388.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004596
  4. NR_148389.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004596
  5. NR_148390.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC004596
    Related
    ENST00000592825.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    44186972..44191929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450929.2XP_024306697.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    pfam00240
    Location:139208
    ubiquitin; Ubiquitin family
  2. XM_047436704.1XP_047292660.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X3

  3. XM_024450930.2XP_024306698.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X5

    Conserved Domains (1) summary
    pfam00240
    Location:130199
    ubiquitin; Ubiquitin family
  4. XM_047436712.1XP_047292668.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X8

  5. XM_047436706.1XP_047292662.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X4

  6. XM_047436707.1XP_047292663.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X4

  7. XM_047436710.1XP_047292666.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7ESS3
  8. XM_047436702.1XP_047292658.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X3

  9. XM_047436703.1XP_047292659.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X3

  10. XM_047436711.1XP_047292667.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X8

  11. XM_011525201.3XP_011523503.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011523503.1

    UniProtKB/Swiss-Prot
    Q71RG4, Q9HAG3
    Conserved Domains (1) summary
    pfam00240
    Location:176245
    ubiquitin; Ubiquitin family
  12. XM_047436708.1XP_047292664.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X2

  13. XM_047436705.1XP_047292661.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X3

  14. XM_047436699.1XP_047292655.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9HAG3
  15. XM_047436700.1XP_047292656.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9HAG3
  16. XM_047436701.1XP_047292657.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X2

  17. XM_011525200.4XP_011523502.2  transmembrane and ubiquitin-like domain-containing protein 2 isoform X2

  18. XM_011525211.4XP_011523513.2  transmembrane and ubiquitin-like domain-containing protein 2 isoform X7

  19. XM_047436709.1XP_047292665.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7ESS3
  20. XM_024450933.2XP_024306701.1  transmembrane and ubiquitin-like domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    E7ESS3
    Conserved Domains (1) summary
    pfam00240
    Location:119188
    ubiquitin; Ubiquitin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    45040074..45045031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)