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PVRIG PVR related immunoglobulin domain containing [ Homo sapiens (human) ]

Gene ID: 79037, updated on 26-Oct-2022

Summary

Official Symbol
PVRIGprovided by HGNC
Official Full Name
PVR related immunoglobulin domain containingprovided by HGNC
Primary source
HGNC:HGNC:32190
See related
Ensembl:ENSG00000213413 MIM:617012; AllianceGenome:HGNC:32190
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD112R; C7orf15
Summary
Enables phosphatase binding activity and signaling receptor activity. Involved in negative regulation of T cell receptor signaling pathway. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lymph node (RPKM 13.9), spleen (RPKM 12.7) and 25 other tissues See more
Orthologs
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Genomic context

See PVRIG in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100219248..100221490)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101459061..101461299)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99816871..99819113)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L29-like Neighboring gene glypican 2 Neighboring gene stromal antigen 3 Neighboring gene CASTOR family member 3, pseudogene Neighboring gene uncharacterized LOC105375426 Neighboring gene speedy/RINGO cell cycle regulator family member E3 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2463, MGC104322, MGC138295, MGC138297

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transmembrane protein PVRIG
Names
CD112 receptor
nectin-2 receptor
poliovirus receptor related immunoglobulin domain containing
poliovirus receptor-related immunoglobulin domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001387134.1NP_001374063.1  transmembrane protein PVRIG isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC005071
    Conserved Domains (2) summary
    cd00096
    Location:2326
    Ig; Ig strand A [structural motif]
    cl11960
    Location:23125
    Ig; Immunoglobulin domain
  2. NM_001397246.1NP_001384175.1  transmembrane protein PVRIG isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC005071
    Consensus CDS
    CCDS94154.1
    Related
    ENSP00000514123.1, ENST00000699088.1
    Conserved Domains (1) summary
    PHA03247
    Location:64304
    PHA03247; large tegument protein UL36; Provisional
  3. NM_024070.3NP_076975.2  transmembrane protein PVRIG isoform 1

    See identical proteins and their annotated locations for NP_076975.2

    Status: VALIDATED

    Source sequence(s)
    AC005071, BC073861
    Consensus CDS
    CCDS5690.1
    UniProtKB/Swiss-Prot
    Q6DKI7, Q9BVK3
    Related
    ENSP00000316675.2, ENST00000317271.3
    Conserved Domains (2) summary
    cl11960
    Location:57145
    Ig; Immunoglobulin domain
    cl26464
    Location:84324
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    100219248..100221490
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    101459061..101461299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)