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FNDC11 fibronectin type III domain containing 11 [ Homo sapiens (human) ]

Gene ID: 79025, updated on 23-Nov-2021

Summary

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Official Symbol
FNDC11provided by HGNC
Official Full Name
fibronectin type III domain containing 11provided by HGNC
Primary source
HGNC:HGNC:28764
See related
Ensembl:ENSG00000125531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf195
Expression
Restricted expression toward testis (RPKM 14.6) See more
Orthologs
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Genomic context

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See FNDC11 in Genome Data Viewer
Location:
20q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63553020..63556712)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62184373..62188061)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 6 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene Sharpr-MPRA regulatory region 13995 Neighboring gene helicase with zinc finger 2 Neighboring gene glucocorticoid modulatory element binding protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Eeles RA, et al. Nat Genet, 2013 Apr. PMID 23535732, Free PMC Article
  2. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  3. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
  4. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article

See all (14) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC5356

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
fibronectin type III domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319152.2 → NP_001306081.1  fibronectin type III domain-containing protein 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AW590437, BC000912, BM554007, BQ109512
    Consensus CDS
    CCDS13526.1
    UniProtKB/Swiss-Prot
    Q9BVV2
    Related
    ENSP00000359115.1, ENST00000370097.2
    Conserved Domains (1) summary
    cd00063
    Location:215 → 289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001319153.2 → NP_001306082.1  fibronectin type III domain-containing protein 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AL121829, AW590437, BC000912, BG772889, BI828873
    Consensus CDS
    CCDS13526.1
    UniProtKB/Swiss-Prot
    Q9BVV2
    Conserved Domains (1) summary
    cd00063
    Location:215 → 289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_024059.3 → NP_076964.1  fibronectin type III domain-containing protein 11

    See identical proteins and their annotated locations for NP_076964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AW590437, BC000912
    Consensus CDS
    CCDS13526.1
    UniProtKB/Swiss-Prot
    Q9BVV2
    Related
    ENSP00000359116.3, ENST00000370098.4
    Conserved Domains (1) summary
    cd00063
    Location:215 → 289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63553020..63556712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529041.2 → XP_011527343.1  fibronectin type III domain-containing protein 11 isoform X2

    See identical proteins and their annotated locations for XP_011527343.1

    UniProtKB/Swiss-Prot
    Q9BVV2
    Related
    ENSP00000480914.1, ENST00000615526.1
    Conserved Domains (1) summary
    cd00063
    Location:215 → 289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_017028060.1 → XP_016883549.1  fibronectin type III domain-containing protein 11 isoform X1

    Conserved Domains (1) summary
    cd00063
    Location:220 → 294
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVV2.1 GenPept UniProtKB/Swiss-Prot:Q9BVV2

Gene LinkOut

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