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FNDC11 fibronectin type III domain containing 11 [ Homo sapiens (human) ]

Gene ID: 79025, updated on 23-Nov-2021

Summary

Official Symbol
FNDC11provided by HGNC
Official Full Name
fibronectin type III domain containing 11provided by HGNC
Primary source
HGNC:HGNC:28764
See related
Ensembl:ENSG00000125531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C20orf195
Expression
Restricted expression toward testis (RPKM 14.6) See more
Orthologs
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Genomic context

See FNDC11 in Genome Data Viewer
Location:
20q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63553020..63556712)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62184373..62188061)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 6 Neighboring gene src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites Neighboring gene Sharpr-MPRA regulatory region 13995 Neighboring gene helicase with zinc finger 2 Neighboring gene glucocorticoid modulatory element binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC5356

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
fibronectin type III domain-containing protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319152.2NP_001306081.1  fibronectin type III domain-containing protein 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AW590437, BC000912, BM554007, BQ109512
    Consensus CDS
    CCDS13526.1
    UniProtKB/Swiss-Prot
    Q9BVV2
    Related
    ENSP00000359115.1, ENST00000370097.2
    Conserved Domains (1) summary
    cd00063
    Location:215289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001319153.2NP_001306082.1  fibronectin type III domain-containing protein 11

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AL121829, AW590437, BC000912, BG772889, BI828873
    Consensus CDS
    CCDS13526.1
    UniProtKB/Swiss-Prot
    Q9BVV2
    Conserved Domains (1) summary
    cd00063
    Location:215289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_024059.3NP_076964.1  fibronectin type III domain-containing protein 11

    See identical proteins and their annotated locations for NP_076964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AW590437, BC000912
    Consensus CDS
    CCDS13526.1
    UniProtKB/Swiss-Prot
    Q9BVV2
    Related
    ENSP00000359116.3, ENST00000370098.4
    Conserved Domains (1) summary
    cd00063
    Location:215289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63553020..63556712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529041.2XP_011527343.1  fibronectin type III domain-containing protein 11 isoform X2

    See identical proteins and their annotated locations for XP_011527343.1

    UniProtKB/Swiss-Prot
    Q9BVV2
    Related
    ENSP00000480914.1, ENST00000615526.1
    Conserved Domains (1) summary
    cd00063
    Location:215289
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_017028060.1XP_016883549.1  fibronectin type III domain-containing protein 11 isoform X1

    Conserved Domains (1) summary
    cd00063
    Location:220294
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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