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GID4 GID complex subunit 4 homolog [ Homo sapiens (human) ]

Gene ID: 79018, updated on 2-Nov-2024

Summary

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Official Symbol
GID4provided by HGNC
Official Full Name
GID complex subunit 4 homologprovided by HGNC
Primary source
HGNC:HGNC:28453
See related
Ensembl:ENSG00000141034 MIM:617699; AllianceGenome:HGNC:28453
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VID2; VID24; C17orf39
Summary
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 9.8), esophagus (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

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See GID4 in Genome Data Viewer
Location:
17p11.2; 17p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (18039408..18068405)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (17986211..18015201)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17942722..17971719)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 3 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 6800 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:17925691-17925854 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11821 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11822 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11824 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991145-17991646 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:17991647-17992146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18010366-18011013 Neighboring gene uncharacterized LOC105371566 Neighboring gene developmentally regulated GTP binding protein 2 Neighboring gene myosin XVA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18038431-18039424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:18039425-18040418 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18045565-18046530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:18046531-18047495 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway. Dong C, et al. Nat Chem Biol, 2018 May. PMID 29632410
  2. The hGID(GID4) E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration. Bagci H, et al. Life Sci Alliance, 2024 Dec. PMID 39389782, Free PMC Article
  3. Recognition of the gluconeogenic enzyme, Pck1, via the Gid4 E3 ligase: An in silico perspective. Ismail AM, et al. J Mol Recognit, 2020 Mar. PMID 31883179
  4. Genomic organisation of the approximately 1.5 Mb Smith-Magenis syndrome critical interval: transcription map, genomic contig, and candidate gene analysis. Lucas RE, et al. Eur J Hum Genet, 2001 Dec. PMID 11840190
  5. The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation. Maitland MER, et al. Sci Rep, 2019 Jul 8. PMID 31285494, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The hGID[GID4] E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration.
    Title: The hGID(GID4) E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration.
  2. Recognition of the gluconeogenic enzyme, Pck1, via the Gid4 E3 ligase: An in silico perspective.
    Title: Recognition of the gluconeogenic enzyme, Pck1, via the Gid4 E3 ligase: An in silico perspective.
  3. crystallographic analysis of human GID4 alone and in complex with various Pro/N-degrons
    Title: Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC3048

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glucose-induced degradation protein 4 homolog
Names
GID complex subunit 4, VID24 homolog
vacuolar import and degradation 24
vacuolar import and degradation protein 24 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411057.1 → NP_001397986.1  glucose-induced degradation protein 4 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087164
    Consensus CDS
    CCDS92267.1
    UniProtKB/TrEMBL
    K4DI96
    Related
    ENSP00000365523.3, ENST00000376345.3

  2. NM_024052.5 → NP_076957.3  glucose-induced degradation protein 4 homolog isoform 1

    See identical proteins and their annotated locations for NP_076957.3

    Status: VALIDATED

    Source sequence(s)
    AC087164, AK127580, BC041829
    Consensus CDS
    CCDS11190.1
    UniProtKB/Swiss-Prot
    Q8IVV7, Q8TEB5, Q9BW50
    Related
    ENSP00000268719.4, ENST00000268719.9
    Conserved Domains (1) summary
    pfam09783
    Location:121 → 289
    Vac_ImportDeg; Vacuolar import and degradation protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    18039408..18068405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256800.2 → XP_005256857.1  glucose-induced degradation protein 4 homolog isoform X1

    Conserved Domains (1) summary
    pfam09783
    Location:121 → 236
    Vac_ImportDeg; Vacuolar import and degradation protein

  2. XM_011524008.2 → XP_011522310.1  glucose-induced degradation protein 4 homolog isoform X2

    Conserved Domains (1) summary
    pfam09783
    Location:122 → 236
    Vac_ImportDeg; Vacuolar import and degradation protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    17986211..18015201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317124.1 → XP_054173099.1  glucose-induced degradation protein 4 homolog isoform X1

  2. XM_054317125.1 → XP_054173100.1  glucose-induced degradation protein 4 homolog isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVV7.1 GenPept UniProtKB/Swiss-Prot:Q8IVV7

Gene LinkOut

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