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GID4 GID complex subunit 4 homolog [ Homo sapiens (human) ]

Gene ID: 79018, updated on 7-Oct-2018

Summary

Official Symbol
GID4provided by HGNC
Official Full Name
GID complex subunit 4 homologprovided by HGNC
Primary source
HGNC:HGNC:28453
See related
Ensembl:ENSG00000141034 MIM:617699; Vega:OTTHUMG00000059398
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VID2; VID24; C17orf39
Summary
The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 9.8), esophagus (RPKM 5.1) and 25 other tissues See more
Orthologs

Genomic context

See GID4 in Genome Data Viewer
Location:
17p11.2; 17p11.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (18039297..18068405)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (17942611..17971719)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene dynein regulatory complex subunit 3 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene uncharacterized LOC105371566 Neighboring gene developmentally regulated GTP binding protein 2 Neighboring gene myosin XVA Neighboring gene uncharacterized LOC105371567

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3048

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glucose-induced degradation protein 4 homolog
Names
GID complex subunit 4, VID24 homolog
vacuolar import and degradation 24
vacuolar import and degradation protein 24 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024052.4NP_076957.3  glucose-induced degradation protein 4 homolog

    See identical proteins and their annotated locations for NP_076957.3

    Status: VALIDATED

    Source sequence(s)
    AK127580, BC041829
    Consensus CDS
    CCDS11190.1
    UniProtKB/Swiss-Prot
    Q8IVV7
    UniProtKB/TrEMBL
    B3KXL6
    Related
    ENSP00000268719.4, OTTHUMP00000065702, ENST00000268719.8, OTTHUMT00000132071
    Conserved Domains (1) summary
    pfam09783
    Location:122289
    Vac_ImportDeg; Vacuolar import and degradation protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    18039297..18068405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256800.2XP_005256857.1  glucose-induced degradation protein 4 homolog isoform X2

    Conserved Domains (1) summary
    pfam09783
    Location:122236
    Vac_ImportDeg; Vacuolar import and degradation protein
  2. XM_011524008.2XP_011522310.1  glucose-induced degradation protein 4 homolog isoform X3

    Conserved Domains (1) summary
    pfam09783
    Location:122236
    Vac_ImportDeg; Vacuolar import and degradation protein
  3. XM_005256799.5XP_005256856.1  glucose-induced degradation protein 4 homolog isoform X1

    UniProtKB/TrEMBL
    K4DI96
    Related
    ENSP00000365523.3, OTTHUMP00000065703, ENST00000376345.3
    Conserved Domains (1) summary
    pfam09783
    Location:122202
    Vac_ImportDeg; Vacuolar import and degradation protein
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