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Chsy3 chondroitin sulfate synthase 3 [ Mus musculus (house mouse) ]

Gene ID: 78923, updated on 18-Apr-2024

Summary

Official Symbol
Chsy3provided by MGI
Official Full Name
chondroitin sulfate synthase 3provided by MGI
Primary source
MGI:MGI:1926173
See related
Ensembl:ENSMUSG00000058152 AllianceGenome:MGI:1926173
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833446K15Rik
Summary
Predicted to enable glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Predicted to be involved in chondroitin sulfate biosynthetic process. Predicted to be located in Golgi cisterna membrane. Predicted to be integral component of membrane. Orthologous to human CHSY3 (chondroitin sulfate synthase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 3.3), limb E14.5 (RPKM 3.1) and 23 other tissues See more
Orthologs
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Genomic context

Location:
18 D3; 18 33.93 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (59308412..59544408)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (59175340..59411336)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 19 Neighboring gene STARR-seq mESC enhancer starr_44706 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene membrane integral NOTCH2 associated receptor 2 Neighboring gene predicted gene, 54033 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 52338 Neighboring gene microRNA 6355

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chondroitin sulfate biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chondroitin sulfate synthase 3
Names
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3
N-acetylgalactosaminyltransferase 3
carbohydrate synthase 2
chSy-2
chondroitin glucuronyltransferase 3
chondroitin synthase 2
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
NP_001074797.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081328.1NP_001074797.1  chondroitin sulfate synthase 3

    See identical proteins and their annotated locations for NP_001074797.1

    Status: PROVISIONAL

    Source sequence(s)
    AC102257, AC127301
    Consensus CDS
    CCDS37829.1
    UniProtKB/Swiss-Prot
    B2RXU7, Q5DTK1
    Related
    ENSMUSP00000079546.5, ENSMUST00000080721.6
    Conserved Domains (3) summary
    pfam05679
    Location:330866
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    pfam16214
    Location:35165
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    cl21608
    Location:170400
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    59308412..59544408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)