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Chsy3 chondroitin sulfate synthase 3 [ Mus musculus (house mouse) ]

Gene ID: 78923, updated on 2-Nov-2024

Summary

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Official Symbol
Chsy3provided by MGI
Official Full Name
chondroitin sulfate synthase 3provided by MGI
Primary source
MGI:MGI:1926173
See related
Ensembl:ENSMUSG00000058152 AllianceGenome:MGI:1926173
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4833446K15Rik
Summary
Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process. Is active in Golgi apparatus. Is expressed in articular cartilage; cartilage; cerebral cortex; and humerus. Orthologous to human CHSY3 (chondroitin sulfate synthase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in placenta adult (RPKM 3.3), limb E14.5 (RPKM 3.1) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Chsy3 in Genome Data Viewer
Location:
18 D3; 18 33.93 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (59308412..59544408)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (59175340..59411336)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 19 Neighboring gene STARR-seq mESC enhancer starr_44706 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene membrane integral NOTCH2 associated receptor 2 Neighboring gene predicted gene, 54033 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 52338 Neighboring gene microRNA 6355

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. Izumikawa T, et al. Biochem J, 2007 May 1. PMID 17253960, Free PMC Article
  2. Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells. Silbert JE, et al. Biochem J, 1980 Aug 15. PMID 6781479, Free PMC Article
  3. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. Sakai K, et al. J Biol Chem, 2007 Feb 9. PMID 17145758
  4. Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis. Hu B, et al. Adv Sci (Weinh), 2022 Oct. PMID 36047655, Free PMC Article
  5. Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2. Shimbo M, et al. PLoS One, 2017. PMID 29287114, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
chondroitin sulfate synthase 3
Names
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3
N-acetylgalactosaminyltransferase 3
carbohydrate synthase 2
chSy-2
chondroitin glucuronyltransferase 3
chondroitin synthase 2
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
NP_001074797.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081328.1 → NP_001074797.1  chondroitin sulfate synthase 3

    See identical proteins and their annotated locations for NP_001074797.1

    Status: PROVISIONAL

    Source sequence(s)
    AC102257, AC127301
    Consensus CDS
    CCDS37829.1
    UniProtKB/Swiss-Prot
    B2RXU7, Q5DTK1
    Related
    ENSMUSP00000079546.5, ENSMUST00000080721.6
    Conserved Domains (3) summary
    pfam05679
    Location:330 → 866
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    pfam16214
    Location:35 → 165
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
    cl21608
    Location:170 → 400
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    59308412..59544408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTK1.3 GenPept UniProtKB/Swiss-Prot:Q5DTK1

Gene LinkOut

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