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CHSY3 chondroitin sulfate synthase 3 [ Homo sapiens (human) ]

Gene ID: 337876, updated on 22-Sep-2022

Summary

Official Symbol
CHSY3provided by HGNC
Official Full Name
chondroitin sulfate synthase 3provided by HGNC
Primary source
HGNC:HGNC:24293
See related
Ensembl:ENSG00000198108 MIM:609963; AllianceGenome:HGNC:24293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSS3; CHSY2
Summary
CSS3 is a glycosyltransferase that has both glucuronyltransferase and N-acetylgalactosaminyltransferase activities (Yada et al., 2003 [PubMed 12907687]).[supplied by OMIM, Mar 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See CHSY3 in Genome Data Viewer
Location:
5q23.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (129903979..130186634)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (130423273..130705475)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (129240158..129522327)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene ADAMTS19 antisense RNA 1 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 19 Neighboring gene membrane integral NOTCH2 associated receptor 2 Neighboring gene uncharacterized LOC112267944 Neighboring gene RNA, U6atac small nuclear 10, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 191 Neighboring gene OCT4-NANOG hESC enhancers GRCh37_chr5:129502144-129502824 and GRCh37_chr5:129502825-129503503 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 4 Neighboring gene uncharacterized LOC105379171 Neighboring gene RNA, U7 small nuclear 53 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
chondroitin sulfate synthase 3
Names
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3
N-acetylgalactosaminyltransferase 3
carbohydrate synthase 2
chSy-2
chondroitin glucuronyltransferase 3
chondroitin synthase-2
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
NP_787052.3
XP_005272039.1
XP_005272040.1
XP_011541665.1
XP_011541666.1
XP_011541667.1
XP_016864923.1
XP_016864924.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175856.5NP_787052.3  chondroitin sulfate synthase 3

    See identical proteins and their annotated locations for NP_787052.3

    Status: VALIDATED

    Source sequence(s)
    AB086062, AC011360, AJ504664, AJ578034
    Consensus CDS
    CCDS34223.1
    UniProtKB/Swiss-Prot
    Q70JA7, Q86Y52
    Related
    ENSP00000302629.4, ENST00000305031.5
    Conserved Domains (2) summary
    pfam05679
    Location:328864
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
    cl21608
    Location:173398
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    129903979..130186634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543363.4XP_011541665.1  chondroitin sulfate synthase 3 isoform X1

    Conserved Domains (1) summary
    pfam05679
    Location:19555
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
  2. XM_011543365.4XP_011541667.1  chondroitin sulfate synthase 3 isoform X4

    Conserved Domains (2) summary
    cl11394
    Location:328369
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    cl21608
    Location:173351
    Galactosyl_T; Galactosyltransferase
  3. XM_005271982.5XP_005272039.1  chondroitin sulfate synthase 3 isoform X5

    Conserved Domains (2) summary
    cl11394
    Location:328362
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    cl21608
    Location:173351
    Galactosyl_T; Galactosyltransferase
  4. XM_017009435.3XP_016864924.1  chondroitin sulfate synthase 3 isoform X3

  5. XM_005271983.5XP_005272040.1  chondroitin sulfate synthase 3 isoform X6

    Conserved Domains (2) summary
    cl11394
    Location:328363
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    cl21608
    Location:173351
    Galactosyl_T; Galactosyltransferase
  6. XM_017009434.2XP_016864923.1  chondroitin sulfate synthase 3 isoform X2

    Conserved Domains (1) summary
    pfam05679
    Location:1502
    CHGN; Chondroitin N-acetylgalactosaminyltransferase
  7. XM_011543364.3XP_011541666.1  chondroitin sulfate synthase 3 isoform X2

    Conserved Domains (1) summary
    pfam05679
    Location:1502
    CHGN; Chondroitin N-acetylgalactosaminyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    130423273..130705475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)