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Cnot10 CCR4-NOT transcription complex, subunit 10 [ Mus musculus (house mouse) ]

Gene ID: 78893, updated on 2-Nov-2024

Summary

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Official Symbol
Cnot10provided by MGI
Official Full Name
CCR4-NOT transcription complex, subunit 10provided by MGI
Primary source
MGI:MGI:1926143
See related
Ensembl:ENSMUSG00000056167 AllianceGenome:MGI:1926143
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600001P13Rik
Summary
Predicted to be involved in mRNA catabolic process and negative regulation of translation. Predicted to be located in cytosol. Predicted to be part of CCR4-NOT complex. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and white fat. Orthologous to human CNOT10 (CCR4-NOT transcription complex subunit 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 25.5), CNS E11.5 (RPKM 22.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cnot10 in Genome Data Viewer
Location:
9 F3; 9 64.72 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (114414942..114469289, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (114585874..114640220, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25350 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114419096-114419279 Neighboring gene C-C motif chemokine receptor 4 Neighboring gene tripartite motif-containing 71 Neighboring gene STARR-seq mESC enhancer starr_25364 Neighboring gene STARR-seq mESC enhancer starr_25369 Neighboring gene STARR-seq mESC enhancer starr_25371 Neighboring gene STARR-seq mESC enhancer starr_25375 Neighboring gene predicted gene, 53512 Neighboring gene STARR-positive B cell enhancer ABC_E9776 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:114549332-114549515 Neighboring gene predicted gene, 51659 Neighboring gene predicted gene 7780 Neighboring gene dynein cytoplasmic 1 light intermediate chain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation. Du H, et al. J Mol Cell Biol, 2020 Oct 26. PMID 33104214, Free PMC Article
  2. Distinct expression patterns of the subunits of the CCR4-NOT deadenylase complex during neural development. Chen C, et al. Biochem Biophys Res Commun, 2011 Jul 29. PMID 21741365
  3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
    Title: RNF219 interacts with CCR4-NOT in regulating stem cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37693

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CCR4-NOT complex ISO
Inferred from Sequence Orthology
more info
  
part_of CCR4-NOT complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CCR4-NOT transcription complex subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153585.5 → NP_705813.2  CCR4-NOT transcription complex subunit 10

    See identical proteins and their annotated locations for NP_705813.2

    Status: VALIDATED

    Source sequence(s)
    AK029103, CA537067, CX222096
    Consensus CDS
    CCDS40794.1
    UniProtKB/Swiss-Prot
    Q05CH8, Q3TSS4, Q3UDS5, Q80VN2, Q8BH15, Q8CI74
    Related
    ENSMUSP00000064840.7, ENSMUST00000070117.8
    Conserved Domains (2) summary
    COG0457
    Location:59 → 274
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:296 → 321
    TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    114414942..114469289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155411.1 → XP_036011304.1  CCR4-NOT transcription complex subunit 10 isoform X4

    Conserved Domains (1) summary
    sd00006
    Location:296 → 321
    TPR; TPR repeat [structural motif]

  2. XM_030244727.2 → XP_030100587.1  CCR4-NOT transcription complex subunit 10 isoform X3

    Conserved Domains (1) summary
    sd00006
    Location:296 → 321
    TPR; TPR repeat [structural motif]

  3. XM_006512399.4 → XP_006512462.1  CCR4-NOT transcription complex subunit 10 isoform X1

    See identical proteins and their annotated locations for XP_006512462.1

    UniProtKB/Swiss-Prot
    Q8BH15
    Conserved Domains (1) summary
    sd00006
    Location:296 → 321
    TPR; TPR repeat [structural motif]

  4. XM_017313699.2 → XP_017169188.1  CCR4-NOT transcription complex subunit 10 isoform X2

    Conserved Domains (1) summary
    sd00006
    Location:296 → 321
    TPR; TPR repeat [structural motif]

RNA

  1. XR_003948060.2 RNA Sequence

  2. XR_003948061.2 RNA Sequence

    Related
    ENSMUST00000215155.2

  3. XR_003948062.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH15.1 GenPept UniProtKB/Swiss-Prot:Q8BH15

Gene LinkOut

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