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CNOT10 CCR4-NOT transcription complex subunit 10 [ Homo sapiens (human) ]

Gene ID: 25904, updated on 8-Jul-2021

Summary

Official Symbol
CNOT10provided by HGNC
Official Full Name
CCR4-NOT transcription complex subunit 10provided by HGNC
Primary source
HGNC:HGNC:23817
See related
Ensembl:ENSG00000182973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 18.8), thyroid (RPKM 7.6) and 24 other tissues See more
Orthologs
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Genomic context

See CNOT10 in Genome Data Viewer
Location:
3p22.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (32685188..32773875)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (32726680..32815367)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene immunoglobulin (CD79A) binding protein 1 pseudogene 3 Neighboring gene ribosomal protein L30 pseudogene 4 Neighboring gene SUGT1 pseudogene 2 Neighboring gene ribosomal protein L23a pseudogene 43 Neighboring gene Sharpr-MPRA regulatory region 2511

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12890, FLJ13165, DKFZp434K115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in gene silencing by RNA IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CCR4-NOT transcription complex subunit 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256741.2NP_001243670.1  CCR4-NOT transcription complex subunit 10 isoform 2

    See identical proteins and their annotated locations for NP_001243670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC138972, AC139452
    Consensus CDS
    CCDS58821.1
    UniProtKB/Swiss-Prot
    Q9H9A5
    Related
    ENSP00000329376.6, ENST00000331889.10
    Conserved Domains (2) summary
    COG0457
    Location:86274
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:296321
    TPR; TPR repeat [structural motif]
  2. NM_001256742.2NP_001243671.1  CCR4-NOT transcription complex subunit 10 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC138972, AC139452
    Consensus CDS
    CCDS58822.1
    UniProtKB/Swiss-Prot
    Q9H9A5
    Related
    ENSP00000399862.2, ENST00000454516.7
    Conserved Domains (2) summary
    COG0457
    Location:146334
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:356381
    TPR; TPR repeat [structural motif]
  3. NM_001393366.1NP_001380295.1  CCR4-NOT transcription complex subunit 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138972, AC139452
    Conserved Domains (2) summary
    COG0457
    Location:86274
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:296321
    TPR; TPR repeat [structural motif]
  4. NM_001393367.1NP_001380296.1  CCR4-NOT transcription complex subunit 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC138972, AC139452
    Conserved Domains (2) summary
    COG0457
    Location:86274
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:296321
    TPR; TPR repeat [structural motif]
  5. NM_001393368.1NP_001380297.1  CCR4-NOT transcription complex subunit 10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC138972, AC139452
    Conserved Domains (2) summary
    COG0457
    Location:86274
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:296321
    TPR; TPR repeat [structural motif]
  6. NM_001393369.1NP_001380298.1  CCR4-NOT transcription complex subunit 10 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC138972, AC139452
    Conserved Domains (2) summary
    COG0457
    Location:86274
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:296321
    TPR; TPR repeat [structural motif]
  7. NM_015442.3NP_056257.1  CCR4-NOT transcription complex subunit 10 isoform 1

    See identical proteins and their annotated locations for NP_056257.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC138972, AC139452
    Consensus CDS
    CCDS2655.1
    UniProtKB/Swiss-Prot
    Q9H9A5
    Related
    ENSP00000330060.5, ENST00000328834.9
    Conserved Domains (2) summary
    COG0457
    Location:86274
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:296321
    TPR; TPR repeat [structural motif]

RNA

  1. NR_046352.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three exons and includes an alternate exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC138972, AC139452
    Related
    ENST00000435630.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    32685188..32773875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713085.3XP_006713148.1  CCR4-NOT transcription complex subunit 10 isoform X2

    Conserved Domains (2) summary
    COG0457
    Location:146334
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:356381
    TPR; TPR repeat [structural motif]
  2. XM_006713084.3XP_006713147.1  CCR4-NOT transcription complex subunit 10 isoform X1

    Conserved Domains (2) summary
    COG0457
    Location:146334
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:356381
    TPR; TPR repeat [structural motif]
  3. XM_011533566.2XP_011531868.1  CCR4-NOT transcription complex subunit 10 isoform X3

    Conserved Domains (2) summary
    COG0457
    Location:146334
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:356381
    TPR; TPR repeat [structural motif]
  4. XM_011533567.2XP_011531869.1  CCR4-NOT transcription complex subunit 10 isoform X8

    Conserved Domains (1) summary
    sd00006
    Location:6893
    TPR; TPR repeat [structural motif]

RNA

  1. XR_001740089.1 RNA Sequence

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