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Sfi1 Sfi1 homolog, spindle assembly associated (yeast) [ Mus musculus (house mouse) ]

Gene ID: 78887, updated on 5-Mar-2024

Summary

Official Symbol
Sfi1provided by MGI
Official Full Name
Sfi1 homolog, spindle assembly associated (yeast)provided by MGI
Primary source
MGI:MGI:1926137
See related
Ensembl:ENSMUSG00000023764 AllianceGenome:MGI:1926137
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable phosphatase binding activity. Predicted to be located in cytoplasm and cytoskeleton. Is expressed in several structures, including alimentary system; metanephros; perioptic mesenchyme; respiratory system; and skeleton. Orthologous to human SFI1 (SFI1 centrin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 8.7), ovary adult (RPKM 8.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
11 A1; 11 2.19 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3081850..3153344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3131850..3203347, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28338 Neighboring gene STARR-positive B cell enhancer mm9_chr11:3020927-3021228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:3023824-3024011 Neighboring gene phosphatidylserine decarboxylase, pseudogene 1 Neighboring gene predicted gene, 33862 Neighboring gene elongation factor 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6943 Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), pseudogene 2 Neighboring gene predicted gene, 51877 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_28343 Neighboring gene STARR-seq mESC enhancer starr_28345 Neighboring gene POZ (BTB) and AT hook containing zinc finger 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • KIAA0542, mKIAA0542, C330046E03, 2310047I15Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363222.1NP_001350151.1  protein SFI1 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL671968, BX572640
    Conserved Domains (1) summary
    pfam08457
    Location:93369
    Sfi1; Sfi1 spindle body protein
  2. NM_001363223.1NP_001350152.1  protein SFI1 homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL671968, BX572640
    Conserved Domains (2) summary
    pfam08457
    Location:93369
    Sfi1; Sfi1 spindle body protein
    cl25732
    Location:669762
    SMC_N; RecF/RecN/SMC N terminal domain
  3. NM_001363224.1NP_001350153.1  protein SFI1 homolog isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL671968, BX572640
    Conserved Domains (2) summary
    pfam08457
    Location:68344
    Sfi1; Sfi1 spindle body protein
    cl25732
    Location:644737
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_030207.3NP_084483.2  protein SFI1 homolog isoform 1

    See identical proteins and their annotated locations for NP_084483.2

    Status: VALIDATED

    Source sequence(s)
    AK133558, BY303229, CK639032
    Consensus CDS
    CCDS36094.1
    UniProtKB/Swiss-Prot
    Q3KQN2, Q3UZY0, Q5NC00, Q6ZQ99, Q80ZJ4, Q80ZY0, Q8R0V8, Q9CTY8
    UniProtKB/TrEMBL
    E9QJT8
    Related
    ENSMUSP00000080066.7, ENSMUST00000081318.13
    Conserved Domains (1) summary
    pfam08457
    Location:328808
    Sfi1; Sfi1 spindle body protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3081850..3153344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006514902.5XP_006514965.1  protein SFI1 homolog isoform X7

    UniProtKB/TrEMBL
    E9QJT8
    Conserved Domains (1) summary
    pfam08457
    Location:328808
    Sfi1; Sfi1 spindle body protein
  2. XM_006514903.5XP_006514966.1  protein SFI1 homolog isoform X8

    UniProtKB/TrEMBL
    E9QJT8
    Conserved Domains (1) summary
    pfam08457
    Location:328808
    Sfi1; Sfi1 spindle body protein
  3. XM_006514900.3XP_006514963.1  protein SFI1 homolog isoform X5

    See identical proteins and their annotated locations for XP_006514963.1

    UniProtKB/TrEMBL
    E9Q799
    Conserved Domains (1) summary
    pfam08457
    Location:182662
    Sfi1; Sfi1 spindle body protein
  4. XM_030246435.1XP_030102295.1  protein SFI1 homolog isoform X17

    Conserved Domains (1) summary
    pfam08457
    Location:32308
    Sfi1; Sfi1 spindle body protein
  5. XM_036157095.1XP_036012988.1  protein SFI1 homolog isoform X10

    UniProtKB/TrEMBL
    E9Q799
    Conserved Domains (1) summary
    pfam08457
    Location:95592
    Sfi1; Sfi1 spindle body protein
  6. XM_011243795.2XP_011242097.1  protein SFI1 homolog isoform X13

    Conserved Domains (1) summary
    pfam08457
    Location:51405
    Sfi1; Sfi1 spindle body protein
  7. XM_011243792.2XP_011242094.1  protein SFI1 homolog isoform X11

    Conserved Domains (2) summary
    pfam08457
    Location:1431
    Sfi1; Sfi1 spindle body protein
    pfam15385
    Location:564713
    SARG; Specifically androgen-regulated gene protein
  8. XM_006514901.3XP_006514964.1  protein SFI1 homolog isoform X6

    UniProtKB/TrEMBL
    E9Q799
    Conserved Domains (1) summary
    pfam08457
    Location:166646
    Sfi1; Sfi1 spindle body protein
  9. XM_036157100.1XP_036012993.1  protein SFI1 homolog isoform X16

    Conserved Domains (1) summary
    pfam08457
    Location:15369
    Sfi1; Sfi1 spindle body protein
  10. XM_036157098.1XP_036012991.1  protein SFI1 homolog isoform X16

    Conserved Domains (1) summary
    pfam08457
    Location:15369
    Sfi1; Sfi1 spindle body protein
  11. XM_036157099.1XP_036012992.1  protein SFI1 homolog isoform X16

    Conserved Domains (1) summary
    pfam08457
    Location:15369
    Sfi1; Sfi1 spindle body protein
  12. XM_030246434.1XP_030102294.1  protein SFI1 homolog isoform X15

    Conserved Domains (1) summary
    pfam08457
    Location:68344
    Sfi1; Sfi1 spindle body protein
  13. XM_006514908.3XP_006514971.1  protein SFI1 homolog isoform X14

    Conserved Domains (1) summary
    pfam08457
    Location:93369
    Sfi1; Sfi1 spindle body protein
  14. XM_030246433.1XP_030102293.1  protein SFI1 homolog isoform X12

    Conserved Domains (1) summary
    pfam08457
    Location:76430
    Sfi1; Sfi1 spindle body protein
  15. XM_006514898.3XP_006514961.1  protein SFI1 homolog isoform X4

    UniProtKB/TrEMBL
    E9QJT8
    Related
    ENSMUSP00000067261.8, ENSMUST00000066391.14
    Conserved Domains (2) summary
    TIGR02169
    Location:10901183
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam08457
    Location:244790
    Sfi1; Sfi1 spindle body protein
  16. XM_006514897.3XP_006514960.1  protein SFI1 homolog isoform X3

    UniProtKB/TrEMBL
    E9QJT8
    Conserved Domains (1) summary
    pfam08457
    Location:211790
    Sfi1; Sfi1 spindle body protein
  17. XM_006514896.3XP_006514959.1  protein SFI1 homolog isoform X2

    See identical proteins and their annotated locations for XP_006514959.1

    UniProtKB/Swiss-Prot
    Q3KQN2, Q3UZY0, Q5NC00, Q6ZQ99, Q80ZJ4, Q80ZY0, Q8R0V8, Q9CTY8
    UniProtKB/TrEMBL
    E9QJT8
    Conserved Domains (1) summary
    pfam08457
    Location:328808
    Sfi1; Sfi1 spindle body protein
  18. XM_006514894.3XP_006514957.1  protein SFI1 homolog isoform X1

    UniProtKB/TrEMBL
    E9QJT8
    Conserved Domains (1) summary
    pfam08457
    Location:328808
    Sfi1; Sfi1 spindle body protein
  19. XM_017314844.1XP_017170333.1  protein SFI1 homolog isoform X15

    Conserved Domains (1) summary
    pfam08457
    Location:68344
    Sfi1; Sfi1 spindle body protein
  20. XM_036157101.1XP_036012994.1  protein SFI1 homolog isoform X16

    Conserved Domains (1) summary
    pfam08457
    Location:15369
    Sfi1; Sfi1 spindle body protein
  21. XM_036157096.1XP_036012989.1  protein SFI1 homolog isoform X12

    Conserved Domains (1) summary
    pfam08457
    Location:76430
    Sfi1; Sfi1 spindle body protein
  22. XM_006514899.3XP_006514962.1  protein SFI1 homolog isoform X5

    See identical proteins and their annotated locations for XP_006514962.1

    UniProtKB/TrEMBL
    E9Q799
    Conserved Domains (1) summary
    pfam08457
    Location:182662
    Sfi1; Sfi1 spindle body protein
  23. XM_017314841.2XP_017170330.1  protein SFI1 homolog isoform X1

    UniProtKB/TrEMBL
    E9QJT8
    Conserved Domains (1) summary
    pfam08457
    Location:328808
    Sfi1; Sfi1 spindle body protein
  24. XM_017314842.3XP_017170331.1  protein SFI1 homolog isoform X1

    UniProtKB/TrEMBL
    E9QJT8
    Conserved Domains (1) summary
    pfam08457
    Location:328808
    Sfi1; Sfi1 spindle body protein
  25. XM_036157097.1XP_036012990.1  protein SFI1 homolog isoform X13

    Conserved Domains (1) summary
    pfam08457
    Location:51405
    Sfi1; Sfi1 spindle body protein
  26. XM_036157094.1XP_036012987.1  protein SFI1 homolog isoform X9

    UniProtKB/TrEMBL
    E9Q799
    Conserved Domains (1) summary
    pfam08457
    Location:112609
    Sfi1; Sfi1 spindle body protein
  27. XM_036157102.1XP_036012995.1  protein SFI1 homolog isoform X18

    Conserved Domains (2) summary
    TIGR02169
    Location:608701
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam08457
    Location:32308
    Sfi1; Sfi1 spindle body protein

RNA

  1. XR_003949531.2 RNA Sequence

  2. XR_004937060.1 RNA Sequence

  3. XR_003949530.2 RNA Sequence

  4. XR_004937059.1 RNA Sequence

  5. XR_001780078.3 RNA Sequence

  6. XR_001780077.3 RNA Sequence

  7. XR_004937058.1 RNA Sequence

  8. XR_380988.5 RNA Sequence

  9. XR_872210.4 RNA Sequence

  10. XR_001780076.3 RNA Sequence

  11. XR_004937061.1 RNA Sequence