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SFI1 SFI1 centrin binding protein [ Homo sapiens (human) ]

Gene ID: 9814, updated on 24-Nov-2020

Summary

Official Symbol
SFI1provided by HGNC
Official Full Name
SFI1 centrin binding proteinprovided by HGNC
Primary source
HGNC:HGNC:29064
See related
Ensembl:ENSG00000198089 MIM:612765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PISD; hSfi1p; PPP1R139
Expression
Broad expression in lymph node (RPKM 6.7), spleen (RPKM 6.6) and 25 other tissues See more
Orthologs

Genomic context

See SFI1 in Genome Data Viewer
Location:
22q12.2
Exon count:
35
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (31496139..31618588)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31892125..32014537)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene RNA, U6 small nuclear 28, pseudogene Neighboring gene H2A.Z histone pseudogene 6 Neighboring gene ribosomal protein S18 pseudogene 14 Neighboring gene VISTA enhancer hs2240 Neighboring gene microRNA 7109 Neighboring gene phosphatidylserine decarboxylase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Sfi1 homolog, spindle assembly associated (yeast) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC57874, MGC131712, MGC150663, MGC156283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
centriole IEA
Inferred from Electronic Annotation
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein SFI1 homolog
Names
Sfi1 homolog, spindle assembly associated
homolog of yeast Sfi1
protein phosphatase 1, regulatory subunit 139

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007467.3NP_001007468.1  protein SFI1 homolog isoform a

    See identical proteins and their annotated locations for NP_001007468.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI141022, AK292408, AL096768, AL708501, BC021576, DC369842
    Consensus CDS
    CCDS43004.1
    UniProtKB/Swiss-Prot
    A8K8P3
    Related
    ENSP00000383145.2, ENST00000400288.7
    Conserved Domains (3) summary
    pfam08457
    Location:340846
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:9631124
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:9861081
    RelB_transactiv; RelB transactivation domain
  2. NM_001258325.1NP_001245254.1  protein SFI1 homolog isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AI141022, AK293987, AL708501, BC021576, DA534059, DC369327, DC369842
    Consensus CDS
    CCDS58803.1
    UniProtKB/Swiss-Prot
    A8K8P3
    Related
    ENSP00000443025.1, ENST00000540643.5
    Conserved Domains (3) summary
    pfam08457
    Location:328791
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:9081069
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:9311026
    RelB_transactiv; RelB transactivation domain
  3. NM_001258326.2NP_001245255.1  protein SFI1 homolog isoform d

    See identical proteins and their annotated locations for NP_001245255.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks two consecutive exons in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AI141022, AL096768, AL708501, BC021576, BC110814, DA202472, DC369842
    Consensus CDS
    CCDS58804.1
    UniProtKB/Swiss-Prot
    A8K8P3
    Related
    ENSP00000383146.1, ENST00000400289.5
    Conserved Domains (3) summary
    pfam08457
    Location:258758
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:8811042
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:904999
    RelB_transactiv; RelB transactivation domain
  4. NM_001258327.2NP_001245256.1  protein SFI1 homolog isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AI141022, AK303362, AL096768, AL708501, DA391957
    UniProtKB/Swiss-Prot
    A8K8P3
    Conserved Domains (3) summary
    pfam08457
    Location:416779
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:8691030
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:892987
    RelB_transactiv; RelB transactivation domain
  5. NM_014775.4NP_055590.2  protein SFI1 homolog isoform b

    See identical proteins and their annotated locations for NP_055590.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB011114, AI141022, AL096768, AL708501, BC021576
    Consensus CDS
    CCDS43005.1
    UniProtKB/Swiss-Prot
    A8K8P3
    Related
    ENSP00000402679.1, ENST00000432498.5
    Conserved Domains (3) summary
    pfam08457
    Location:352815
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:9321093
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:9551050
    RelB_transactiv; RelB transactivation domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    31496139..31618588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530570.2XP_011528872.1  protein SFI1 homolog isoform X1

    See identical proteins and their annotated locations for XP_011528872.1

    Conserved Domains (2) summary
    pfam08457
    Location:340828
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:10031101
    RelB_transactiv; RelB transactivation domain
  2. XM_011530575.2XP_011528877.1  protein SFI1 homolog isoform X6

    Conserved Domains (2) summary
    pfam08457
    Location:340846
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:9861084
    RelB_transactiv; RelB transactivation domain
  3. XM_005261868.2XP_005261925.1  protein SFI1 homolog isoform X7

    Conserved Domains (3) summary
    pfam08457
    Location:340846
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:9631124
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:9861081
    RelB_transactiv; RelB transactivation domain
  4. XM_011530580.2XP_011528882.1  protein SFI1 homolog isoform X9

    Conserved Domains (2) summary
    pfam08457
    Location:144683
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:9721070
    RelB_transactiv; RelB transactivation domain
  5. XM_017029144.1XP_016884633.1  protein SFI1 homolog isoform X13

  6. XM_024452311.1XP_024308079.1  protein SFI1 homolog isoform X32

    Conserved Domains (2) summary
    pfam08457
    Location:2234
    Sfi1; Sfi1 spindle body protein
    cl26464
    Location:301490
    Atrophin-1; Atrophin-1 family
  7. XM_011530576.2XP_011528878.1  protein SFI1 homolog isoform X3

    See identical proteins and their annotated locations for XP_011528878.1

    Conserved Domains (2) summary
    pfam08457
    Location:316804
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:9791077
    RelB_transactiv; RelB transactivation domain
  8. XM_017029142.1XP_016884631.1  protein SFI1 homolog isoform X12

  9. XM_017029149.2XP_016884638.1  protein SFI1 homolog isoform X19

  10. XM_017029140.1XP_016884629.1  protein SFI1 homolog isoform X10

  11. XM_017029147.1XP_016884636.1  protein SFI1 homolog isoform X18

  12. XM_017029145.1XP_016884634.1  protein SFI1 homolog isoform X14

  13. XM_024452309.1XP_024308077.1  protein SFI1 homolog isoform X30

    Conserved Domains (2) summary
    pfam08457
    Location:2243
    Sfi1; Sfi1 spindle body protein
    cl25496
    Location:377505
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  14. XM_024452310.1XP_024308078.1  protein SFI1 homolog isoform X31

    Conserved Domains (2) summary
    pfam08457
    Location:2243
    Sfi1; Sfi1 spindle body protein
    cl26464
    Location:297490
    Atrophin-1; Atrophin-1 family
  15. XM_017029159.2XP_016884648.1  protein SFI1 homolog isoform X29

    Conserved Domains (2) summary
    pfam16181
    Location:436534
    RelB_transactiv; RelB transactivation domain
    cl00459
    Location:600642
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
  16. XM_011530582.2XP_011528884.1  protein SFI1 homolog isoform X16

    See identical proteins and their annotated locations for XP_011528884.1

    Conserved Domains (2) summary
    pfam08457
    Location:258746
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:9211019
    RelB_transactiv; RelB transactivation domain
  17. XM_006724390.3XP_006724453.1  protein SFI1 homolog isoform X24

    See identical proteins and their annotated locations for XP_006724453.1

    UniProtKB/Swiss-Prot
    A8K8P3
    Related
    ENSP00000401199.1, ENST00000443011.5
    Conserved Domains (3) summary
    pfam08457
    Location:258758
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:8811042
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:904999
    RelB_transactiv; RelB transactivation domain
  18. XM_017029152.1XP_016884641.1  protein SFI1 homolog isoform X21

  19. XM_017029155.1XP_016884644.1  protein SFI1 homolog isoform X25

  20. XM_017029156.2XP_016884645.1  protein SFI1 homolog isoform X26

  21. XM_011530571.2XP_011528873.1  protein SFI1 homolog isoform X1

    See identical proteins and their annotated locations for XP_011528873.1

    Conserved Domains (2) summary
    pfam08457
    Location:340828
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:10031101
    RelB_transactiv; RelB transactivation domain
  22. XM_017029143.1XP_016884632.1  protein SFI1 homolog isoform X8

  23. XM_017029151.2XP_016884640.1  protein SFI1 homolog isoform X20

    UniProtKB/Swiss-Prot
    A8K8P3
    Conserved Domains (3) summary
    pfam08457
    Location:352815
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:9321093
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:9551050
    RelB_transactiv; RelB transactivation domain
  24. XM_011530577.2XP_011528879.1  protein SFI1 homolog isoform X3

    See identical proteins and their annotated locations for XP_011528879.1

    Conserved Domains (2) summary
    pfam08457
    Location:316804
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:9791077
    RelB_transactiv; RelB transactivation domain
  25. XM_017029150.2XP_016884639.1  protein SFI1 homolog isoform X19

  26. XM_017029148.1XP_016884637.1  protein SFI1 homolog isoform X18

  27. XM_017029154.2XP_016884643.1  protein SFI1 homolog isoform X23

    UniProtKB/Swiss-Prot
    A8K8P3
    Conserved Domains (3) summary
    pfam08457
    Location:328791
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:9081069
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:9311026
    RelB_transactiv; RelB transactivation domain
  28. XM_011530583.2XP_011528885.1  protein SFI1 homolog isoform X16

    See identical proteins and their annotated locations for XP_011528885.1

    Conserved Domains (2) summary
    pfam08457
    Location:258746
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:9211019
    RelB_transactiv; RelB transactivation domain
  29. XM_017029153.1XP_016884642.1  protein SFI1 homolog isoform X22

  30. XM_017029158.1XP_016884647.1  protein SFI1 homolog isoform X28

  31. XM_011530579.3XP_011528881.1  protein SFI1 homolog isoform X4

    Conserved Domains (2) summary
    pfam08457
    Location:340828
    Sfi1; Sfi1 spindle body protein
    pfam16181
    Location:10031101
    RelB_transactiv; RelB transactivation domain
  32. XM_011530574.3XP_011528876.1  protein SFI1 homolog isoform X2

    Conserved Domains (3) summary
    pfam08457
    Location:340828
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:9801141
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:10031098
    RelB_transactiv; RelB transactivation domain
  33. XM_011530581.3XP_011528883.1  protein SFI1 homolog isoform X5

    Conserved Domains (3) summary
    pfam08457
    Location:340828
    Sfi1; Sfi1 spindle body protein
    pfam11235
    Location:9801141
    Med25_SD1; Mediator complex subunit 25 synapsin 1
    pfam16181
    Location:10031098
    RelB_transactiv; RelB transactivation domain
  34. XM_017029146.2XP_016884635.1  protein SFI1 homolog isoform X17

  35. XM_017029141.2XP_016884630.1  protein SFI1 homolog isoform X11

  36. XM_017029139.2XP_016884628.1  protein SFI1 homolog isoform X8

  37. XM_024452308.1XP_024308076.1  protein SFI1 homolog isoform X15

    Conserved Domains (2) summary
    pfam08457
    Location:352815
    Sfi1; Sfi1 spindle body protein
    cl26464
    Location:9451109
    Atrophin-1; Atrophin-1 family
  38. XM_017029157.1XP_016884646.1  protein SFI1 homolog isoform X27

  39. XM_011530587.3XP_011528889.1  protein SFI1 homolog isoform X29

    See identical proteins and their annotated locations for XP_011528889.1

    Conserved Domains (2) summary
    pfam16181
    Location:436534
    RelB_transactiv; RelB transactivation domain
    cl00459
    Location:600642
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
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