U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Usp54 ubiquitin specific peptidase 54 [ Mus musculus (house mouse) ]

Gene ID: 78787, updated on 9-May-2024

Summary

Official Symbol
Usp54provided by MGI
Official Full Name
ubiquitin specific peptidase 54provided by MGI
Primary source
MGI:MGI:1926037
See related
Ensembl:ENSMUSG00000034235 AllianceGenome:MGI:1926037
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930429G18Rik; C030002J06Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Orthologous to human USP54 (ubiquitin specific peptidase 54). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.3), cortex adult (RPKM 4.8) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Usp54 in Genome Data Viewer
Location:
14 A3; 14 11.53 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20598980..20694559, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20548912..20644491, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene MSS51 mitochondrial translational activator Neighboring gene STARR-seq mESC enhancer starr_36112 Neighboring gene protein phosphatase 3, catalytic subunit, beta isoform Neighboring gene RIKEN cDNA 1810062O18 gene Neighboring gene STARR-positive B cell enhancer ABC_E11565 Neighboring gene STARR-positive B cell enhancer ABC_E7297 Neighboring gene myozenin 1 Neighboring gene synaptopodin 2-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
inactive ubiquitin carboxyl-terminal hydrolase 54
Names
inactive ubiquitin-specific peptidase 54
ubiquitin specific protease 54

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403077.1NP_001390006.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC146594
  2. NM_001403078.1NP_001390007.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC146594
    UniProtKB/Swiss-Prot
    Q149D8, Q149D9, Q6NZE1, Q8BL06, Q8BZ28, Q9D2I9
    Related
    ENSMUSP00000022356.5, ENSMUST00000022356.12
  3. NM_001403079.1NP_001390008.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC146594
  4. NM_001403080.1NP_001390009.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC146594
  5. NM_001403081.1NP_001390010.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC146594
  6. NM_030180.3NP_084456.2  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1

    See identical proteins and their annotated locations for NP_084456.2

    Status: VALIDATED

    Source sequence(s)
    AC146594
    Consensus CDS
    CCDS26847.2
    UniProtKB/Swiss-Prot
    Q149D8, Q149D9, Q6NZE1, Q8BL06, Q8BZ28, Q9D2I9
    Related
    ENSMUSP00000036214.8, ENSMUST00000035340.14
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase

RNA

  1. NR_175348.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC146594
  2. NR_175349.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC146594

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    20598980..20694559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158911.1XP_036014804.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X3

    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. XM_036158913.1XP_036014806.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X6

    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. XM_036158908.1XP_036014801.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  4. XM_036158915.1XP_036014808.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X9

  5. XM_036158910.1XP_036014803.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  6. XM_036158909.1XP_036014802.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X1

    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  7. XM_036158912.1XP_036014805.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform X5

    Conserved Domains (1) summary
    cd02257
    Location:12220
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

  1. XR_001781171.2 RNA Sequence

  2. XR_001781170.2 RNA Sequence

  3. XR_004938462.1 RNA Sequence

  4. XR_004938461.1 RNA Sequence

  5. XR_001781172.2 RNA Sequence