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USP54 ubiquitin specific peptidase 54 [ Homo sapiens (human) ]

Gene ID: 159195, updated on 8-Jan-2023

Summary

Official Symbol
USP54provided by HGNC
Official Full Name
ubiquitin specific peptidase 54provided by HGNC
Primary source
HGNC:HGNC:23513
See related
Ensembl:ENSG00000166348 AllianceGenome:HGNC:23513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf29; bA137L10.3; bA137L10.4
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thyroid (RPKM 13.4), brain (RPKM 8.5) and 22 other tissues See more
Orthologs
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Genomic context

See USP54 in Genome Data Viewer
Location:
10q22.2
Exon count:
29
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73497538..73625981, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74368953..74497405, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75257296..75385739, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene MSS51 mitochondrial translational activator Neighboring gene protein phosphatase 3 catalytic subunit beta Neighboring gene PPP3CB antisense RNA 1 (head to head) Neighboring gene Sharpr-MPRA regulatory region 13746 Neighboring gene RNA, U6 small nuclear 883, pseudogene Neighboring gene ribosomal protein S26 pseudogene 41 Neighboring gene myozenin 1 Neighboring gene Sharpr-MPRA regulatory region 4994 Neighboring gene SYNPO2L antisense RNA 1 Neighboring gene synaptopodin 2 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ37318

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inactive ubiquitin carboxyl-terminal hydrolase 54
Names
inactive ubiquitin-specific peptidase 54
ubiquitin specific protease 54
ubiquitin specific proteinase 54

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320437.2NP_001307366.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK127267, AK302598, AL359074, BC064967, DA327288, DC322498
    UniProtKB/Swiss-Prot
    Q70EL1
    UniProtKB/TrEMBL
    B7Z7X1
    Conserved Domains (2) summary
    cd02257
    Location:32349
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_001320441.2NP_001307370.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK302598, AL359074, DC322498
    UniProtKB/TrEMBL
    B7Z7X1
    Related
    ENSP00000510416.1, ENST00000687418.1
    Conserved Domains (3) summary
    cd02257
    Location:120349
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cl02553
    Location:40176
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. NM_001350995.2NP_001337924.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC073389, AK127267, AK302598, AL359074, BC026037, BC064967
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  4. NM_001378208.1NP_001365137.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  5. NM_001378209.1NP_001365138.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  6. NM_001378210.1NP_001365139.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  7. NM_001391941.1NP_001378870.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32371
    UCH; Ubiquitin carboxyl-terminal hydrolase
  8. NM_001391942.1NP_001378871.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  9. NM_001391945.1NP_001378874.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  10. NM_001391946.1NP_001378875.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  11. NM_001391947.1NP_001378876.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  12. NM_001391948.1NP_001378877.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  13. NM_001391949.1NP_001378878.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Consensus CDS
    CCDS91265.1
    UniProtKB/TrEMBL
    A0A7P0T9K1
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  14. NM_001391950.1NP_001378879.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  15. NM_001391951.1NP_001378880.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32128
    UCH; Ubiquitin carboxyl-terminal hydrolase
  16. NM_001391952.1NP_001378881.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Consensus CDS
    CCDS91265.1
    UniProtKB/TrEMBL
    A0A7P0T9K1
    Related
    ENSP00000505692.1, ENST00000681793.1
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  17. NM_001391953.1NP_001378882.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Consensus CDS
    CCDS7329.2
    UniProtKB/Swiss-Prot
    Q8N1X2
    Related
    ENSP00000345216.4, ENST00000339859.8
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  18. NM_001391954.1NP_001378883.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  19. NM_001391955.1NP_001378884.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL359074
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  20. NM_001391956.1NP_001378885.1  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL359074
    Consensus CDS
    CCDS7329.2
    UniProtKB/Swiss-Prot
    Q8N1X2
    Related
    ENSP00000510226.1, ENST00000687698.1
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase
  21. NM_152586.4NP_689799.3  inactive ubiquitin carboxyl-terminal hydrolase 54 isoform 1

    See identical proteins and their annotated locations for NP_689799.3

    Status: VALIDATED

    Source sequence(s)
    AC073389, AL359074
    Consensus CDS
    CCDS7329.2
    UniProtKB/Swiss-Prot
    Q70EL1, Q8N1X2
    Conserved Domains (1) summary
    pfam00443
    Location:32349
    UCH; Ubiquitin carboxyl-terminal hydrolase

RNA

  1. NR_135249.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK302598, AL359074, BC064967, BC110845, DC322498
  2. NR_135250.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK127267, AL359074, BC064967
    Related
    ENST00000497106.5
  3. NR_146997.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK302598, AL359074, BC026037, BC064967, BC110845, DA416496, DC322498
  4. NR_146998.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK302598, AL359074, BC026037, BC064967, BC110845, BC130633, DA416496, DC322498
    Related
    ENST00000422491.7
  5. NR_165442.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359074
    Related
    ENST00000691043.1
  6. NR_165443.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL359074
    Related
    ENST00000693251.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73497538..73625981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74368953..74497405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)