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KMT2B lysine methyltransferase 2B [ Bos taurus (domestic cattle) ]

Gene ID: 785776, updated on 17-Aug-2024

Summary

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Official Symbol
KMT2Bprovided by VGNC
Official Full Name
lysine methyltransferase 2Bprovided by VGNC
Primary source
VGNC:VGNC:30691
See related
Ensembl:ENSBTAG00000002763
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 18 NC_037345.1 (46433304..46453716)

Chromosome 18 - NC_037345.1Genomic Context describing neighboring genes Neighboring gene uroplakin 1A Neighboring gene zinc finger and BTB domain containing 32 Neighboring gene IGF like family receptor 1 Neighboring gene U2 small nuclear RNA auxiliary factor 1 like 4 Neighboring gene presenilin enhancer, gamma-secretase subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037345.1 Chromosome 18 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K4 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone methyltransferase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037345.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    46433304..46453716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059877503.1 → XP_059733486.1  histone-lysine N-methyltransferase 2B isoform X1

    UniProtKB/TrEMBL
    A0A3Q1M7X1

  2. XM_003587241.6 → XP_003587289.1  histone-lysine N-methyltransferase 2B isoform X2

    UniProtKB/TrEMBL
    A0A3Q1M7X1, E1BKN0
    Related
    ENSBTAP00000003584.5, ENSBTAT00000003584.7
    Conserved Domains (10) summary
    cd05493
    Location:1369 → 1511
    Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...
    smart00542
    Location:2409 → 2493
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:2573 → 2693
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG2940
    Location:2555 → 2711
    SET; SET domain-containing protein (function unknown) [General function prediction only]
    pfam02008
    Location:952 → 999
    zf-CXXC; CXXC zinc finger domain
    cd15589
    Location:1198 → 1244
    PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15591
    Location:1246 → 1295
    PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15593
    Location:1332 → 1388
    PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)
    cd15694
    Location:1576 → 1680
    ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)
    pfam05964
    Location:1729 → 1775
    FYRN; F/Y-rich N-terminus

  3. XM_059877504.1 → XP_059733487.1  histone-lysine N-methyltransferase 2B isoform X3

    UniProtKB/TrEMBL
    A0A3Q1M7X1
    Related
    ENSBTAP00000066181.1, ENSBTAT00000082857.2

  4. XM_059877505.1 → XP_059733488.1  histone-lysine N-methyltransferase 2B isoform X4

    UniProtKB/TrEMBL
    A0A3Q1M7X1

  5. XM_059877506.1 → XP_059733489.1  histone-lysine N-methyltransferase 2B isoform X5

    UniProtKB/TrEMBL
    A0A3Q1M7X1

  6. XM_059877508.1 → XP_059733491.1  histone-lysine N-methyltransferase 2B isoform X6

    UniProtKB/TrEMBL
    A0A3Q1M7X1

  7. XM_059877507.1 → XP_059733490.1  histone-lysine N-methyltransferase 2B isoform X6

    UniProtKB/TrEMBL
    A0A3Q1M7X1
Nucleotide Protein
Heading Accession and Version

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