U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cul9 cullin 9 [ Mus musculus (house mouse) ]

Gene ID: 78309, updated on 8-Feb-2024

Summary

Official Symbol
Cul9provided by MGI
Official Full Name
cullin 9provided by MGI
Primary source
MGI:MGI:1925559
See related
Ensembl:ENSMUSG00000040327 AllianceGenome:MGI:1925559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Parc; Cul-9; mKIAA0708; 1810035I07Rik
Summary
Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Predicted to be located in cytosol. Predicted to be part of cullin-RING ubiquitin ligase complex. Is expressed in several structures, including brain; retina nuclear layer; and testis. Orthologous to human CUL9 (cullin 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.3), adrenal adult (RPKM 12.3) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cul9 in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46811535..46857314, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46500609..46546388, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42667 Neighboring gene tau tubulin kinase 1 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cullin-9
Names
p53-associated parkin-like cytoplasmic protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081335.2NP_001074804.2  cullin-9

    Status: VALIDATED

    Source sequence(s)
    AK051474, AK147675, AK162968, BP753198, CF534354, CJ110581
    Consensus CDS
    CCDS37636.2
    UniProtKB/TrEMBL
    E9QP09, S4R1Y1
    Related
    ENSMUSP00000138418.2, ENSMUST00000182485.8
    Conserved Domains (7) summary
    COG5647
    Location:16941947
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cl02148
    Location:11691299
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00888
    Location:15971815
    Cullin; Cullin family
    pfam11515
    Location:367441
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cd20347
    Location:21502223
    BRcat_RBR_CUL9; BRcat domain found in cullin-9 (CUL-9) and similar proteins
    cd20359
    Location:22312288
    Rcat_RBR_CUL9; Rcat domain found in cullin-9 (CUL-9) and similar proteins
    cl17238
    Location:20722124
    RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46811535..46857314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246723.4XP_011245025.1  cullin-9 isoform X2

    UniProtKB/TrEMBL
    E9QP09
    Conserved Domains (8) summary
    smart00647
    Location:21832245
    IBR; In Between Ring fingers
    COG5647
    Location:17321985
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:21122162
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00888
    Location:17361852
    Cullin; Cullin family
    pfam01485
    Location:22762311
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:382456
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:11841314
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl17238
    Location:21112162
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  2. XM_011246722.4XP_011245024.1  cullin-9 isoform X1

    UniProtKB/TrEMBL
    E9QP09
    Conserved Domains (8) summary
    smart00647
    Location:21872249
    IBR; In Between Ring fingers
    COG5647
    Location:17361989
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:21162166
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00888
    Location:17401856
    Cullin; Cullin family
    pfam01485
    Location:22802315
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:382456
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:11841314
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl17238
    Location:21152166
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  3. XM_006525135.5XP_006525198.1  cullin-9 isoform X3

    UniProtKB/TrEMBL
    E9QP09
    Related
    ENSMUST00000182315.8
    Conserved Domains (8) summary
    smart00647
    Location:21602222
    IBR; In Between Ring fingers
    COG5647
    Location:17091962
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:20892139
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00888
    Location:16121829
    Cullin; Cullin family
    pfam01485
    Location:22532288
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:382456
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:11841314
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl17238
    Location:20882139
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  4. XM_006525136.5XP_006525199.1  cullin-9 isoform X4

    UniProtKB/TrEMBL
    E9QP09
    Conserved Domains (8) summary
    smart00647
    Location:21602222
    IBR; In Between Ring fingers
    COG5647
    Location:17091962
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:20892139
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00888
    Location:16121829
    Cullin; Cullin family
    pfam01485
    Location:22532288
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:382456
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:11841314
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl17238
    Location:20882139
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain