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Cul9 cullin 9 [ Mus musculus (house mouse) ]

Gene ID: 78309, updated on 2-Nov-2024

Summary

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Official Symbol
Cul9provided by MGI
Official Full Name
cullin 9provided by MGI
Primary source
MGI:MGI:1925559
See related
Ensembl:ENSMUSG00000040327 AllianceGenome:MGI:1925559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Parc; Cul-9; mKIAA0708; 1810035I07Rik
Summary
Predicted to enable several functions, including ATP binding activity; ubiquitin protein ligase binding activity; and zinc ion binding activity. Predicted to be involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Predicted to be located in cytosol. Predicted to be part of cullin-RING ubiquitin ligase complex. Is expressed in several structures, including brain; hemolymphoid system gland; muscle tissue; retina nuclear layer; and testis. Orthologous to human CUL9 (cullin 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 12.3), adrenal adult (RPKM 12.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Cul9 in Genome Data Viewer
Location:
17 C; 17 22.9 cM
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46811535..46857314, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46500609..46546388, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42667 Neighboring gene tau tubulin kinase 1 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease. Hollville E, et al. Sci Rep, 2020 Oct 9. PMID 33037272, Free PMC Article
  2. Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamics via Survivin. Dai X, et al. Biochim Biophys Acta, 2016 Dec. PMID 27678504
  3. Cytoplasmic E3 ubiquitin ligase CUL9 controls cell proliferation, senescence, apoptosis and genome integrity through p53. Li Z, et al. Oncogene, 2017 Sep 7. PMID 28481879, Free PMC Article
  4. Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Pei XH, et al. Cancer Res, 2011 Apr 15. PMID 21487039, Free PMC Article
  5. Identification of far upstream element-binding protein-1 as an authentic Parkin substrate. Ko HS, et al. J Biol Chem, 2006 Jun 16. PMID 16672220

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.
    Title: Characterization of a Cul9-Parkin double knockout mouse model for Parkinson's disease.
  2. The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
    Title: Cullin9 protects mouse eggs from aneuploidy by controlling microtubule dynamics via Survivin.
  3. A 3M-CUL9-survivin pathway is implicated in maintaining microtubule and genome integrity, normal development, and tumor suppression.
    Title: CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity.
  4. Dimerization of Cul7 and Parc is not required for all Cul7 functions and mouse development.
    Title: Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development.
  5. FUBP1 is an authentic substrate of Parkin that might play an important role in development of Parkinson disease pathology along with aminoacyl-tRNA synthetase interacting multifunctional protein type 2
    Title: Identification of far upstream element-binding protein-1 as an authentic Parkin substrate.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic nuclear division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cullin-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of cullin-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cullin-9
Names
p53-associated parkin-like cytoplasmic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081335.2 → NP_001074804.2  cullin-9

    Status: VALIDATED

    Source sequence(s)
    AK051474, AK147675, AK162968, BP753198, CF534354, CJ110581
    Consensus CDS
    CCDS37636.2
    UniProtKB/TrEMBL
    E9QP09, S4R1Y1
    Related
    ENSMUSP00000138418.2, ENSMUST00000182485.8
    Conserved Domains (7) summary
    COG5647
    Location:1694 → 1947
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cl02148
    Location:1169 → 1299
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00888
    Location:1597 → 1815
    Cullin; Cullin family
    pfam11515
    Location:367 → 441
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cd20347
    Location:2150 → 2223
    BRcat_RBR_CUL9; BRcat domain found in cullin-9 (CUL-9) and similar proteins
    cd20359
    Location:2231 → 2288
    Rcat_RBR_CUL9; Rcat domain found in cullin-9 (CUL-9) and similar proteins
    cl17238
    Location:2072 → 2124
    RING_Ubox; RING finger (Really Interesting New Gene) domain and U-box domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    46811535..46857314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246723.4 → XP_011245025.1  cullin-9 isoform X2

    UniProtKB/TrEMBL
    E9QP09
    Conserved Domains (8) summary
    smart00647
    Location:2183 → 2245
    IBR; In Between Ring fingers
    COG5647
    Location:1732 → 1985
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:2112 → 2162
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00888
    Location:1736 → 1852
    Cullin; Cullin family
    pfam01485
    Location:2276 → 2311
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:382 → 456
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:1184 → 1314
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl17238
    Location:2111 → 2162
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  2. XM_011246722.4 → XP_011245024.1  cullin-9 isoform X1

    UniProtKB/TrEMBL
    E9QP09
    Conserved Domains (8) summary
    smart00647
    Location:2187 → 2249
    IBR; In Between Ring fingers
    COG5647
    Location:1736 → 1989
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:2116 → 2166
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00888
    Location:1740 → 1856
    Cullin; Cullin family
    pfam01485
    Location:2280 → 2315
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:382 → 456
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:1184 → 1314
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl17238
    Location:2115 → 2166
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_006525135.5 → XP_006525198.1  cullin-9 isoform X3

    UniProtKB/TrEMBL
    E9QP09
    Related
    ENSMUST00000182315.8
    Conserved Domains (8) summary
    smart00647
    Location:2160 → 2222
    IBR; In Between Ring fingers
    COG5647
    Location:1709 → 1962
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:2089 → 2139
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00888
    Location:1612 → 1829
    Cullin; Cullin family
    pfam01485
    Location:2253 → 2288
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:382 → 456
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:1184 → 1314
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl17238
    Location:2088 → 2139
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  4. XM_006525136.5 → XP_006525199.1  cullin-9 isoform X4

    UniProtKB/TrEMBL
    E9QP09
    Conserved Domains (8) summary
    smart00647
    Location:2160 → 2222
    IBR; In Between Ring fingers
    COG5647
    Location:1709 → 1962
    COG5647; Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones]
    cd00162
    Location:2089 → 2139
    RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
    pfam00888
    Location:1612 → 1829
    Cullin; Cullin family
    pfam01485
    Location:2253 → 2288
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:382 → 456
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    cl02148
    Location:1184 → 1314
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl17238
    Location:2088 → 2139
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80TT8.2 GenPept UniProtKB/Swiss-Prot:Q80TT8

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