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CUL9 cullin 9 [ Homo sapiens (human) ]

Gene ID: 23113, updated on 5-Aug-2018

Summary

Official Symbol
CUL9provided by HGNC
Official Full Name
cullin 9provided by HGNC
Primary source
HGNC:HGNC:15982
See related
Ensembl:ENSG00000112659 MIM:607489; Vega:OTTHUMG00000014723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARC; H7AP1
Expression
Ubiquitous expression in testis (RPKM 6.1), skin (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See CUL9 in Genome Data Viewer
Location:
6p21.1
Exon count:
43
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (43182170..43224587)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43149913..43192325)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene serum response factor Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene tau tubulin kinase 1 Neighboring gene uncharacterized LOC105375064

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686G1042, DKFZp686P2024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cullin-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cullin-9
Names
CUL-9
UbcH7-associated protein 1
p53-associated parkin-like cytoplasmic protein
parkin-like cytoplasmic p53 binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015089.3NP_055904.1  cullin-9

    See identical proteins and their annotated locations for NP_055904.1

    Status: VALIDATED

    Source sequence(s)
    AJ318215, AL133375, BC002879, KF458162
    Consensus CDS
    CCDS4890.1
    UniProtKB/Swiss-Prot
    Q8IWT3
    Related
    ENSP00000252050.4, OTTHUMP00000016423, ENST00000252050.8, OTTHUMT00000040582
    Conserved Domains (8) summary
    smart00182
    Location:15931764
    CULLIN; Cullin
    smart00647
    Location:21412203
    IBR; In Between Ring fingers
    pfam01485
    Location:22342272
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:20682117
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:18641944
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    43182170..43224587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514423.2XP_011512725.1  cullin-9 isoform X1

    See identical proteins and their annotated locations for XP_011512725.1

    Conserved Domains (8) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    smart00647
    Location:21902252
    IBR; In Between Ring fingers
    pfam01485
    Location:22832321
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:21172166
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:19131993
    Cullin_Nedd8; Cullin protein neddylation domain
  2. XM_011514422.1XP_011512724.1  cullin-9 isoform X1

    See identical proteins and their annotated locations for XP_011512724.1

    Conserved Domains (8) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    smart00647
    Location:21902252
    IBR; In Between Ring fingers
    pfam01485
    Location:22832321
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:21172166
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:19131993
    Cullin_Nedd8; Cullin protein neddylation domain
  3. XM_011514424.1XP_011512726.1  cullin-9 isoform X2

    Conserved Domains (8) summary
    smart00182
    Location:16151786
    CULLIN; Cullin
    smart00647
    Location:21632225
    IBR; In Between Ring fingers
    pfam01485
    Location:22562294
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:20902139
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11401270
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:18861966
    Cullin_Nedd8; Cullin protein neddylation domain
  4. XM_011514425.1XP_011512727.1  cullin-9 isoform X3

    Conserved Domains (8) summary
    smart00182
    Location:15321703
    CULLIN; Cullin
    smart00647
    Location:20802142
    IBR; In Between Ring fingers
    pfam01485
    Location:21732211
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366419
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:20072056
    zf-RING_2; Ring finger domain
    pfam16195
    Location:483528
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:10571187
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:18031883
    Cullin_Nedd8; Cullin protein neddylation domain
  5. XM_011514426.1XP_011512728.1  cullin-9 isoform X4

    Conserved Domains (8) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    smart00647
    Location:21902252
    IBR; In Between Ring fingers
    pfam01485
    Location:22832321
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:21172166
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:19131993
    Cullin_Nedd8; Cullin protein neddylation domain
  6. XM_011514428.1XP_011512730.1  cullin-9 isoform X7

    Conserved Domains (4) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  7. XM_011514430.1XP_011512732.1  cullin-9 isoform X9

    Conserved Domains (3) summary
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  8. XM_017010589.1XP_016866078.1  cullin-9 isoform X1

    Conserved Domains (8) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    smart00647
    Location:21902252
    IBR; In Between Ring fingers
    pfam01485
    Location:22832321
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:21172166
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:19131993
    Cullin_Nedd8; Cullin protein neddylation domain
  9. XM_011514427.1XP_011512729.1  cullin-9 isoform X5

    Conserved Domains (6) summary
    smart00182
    Location:11711342
    CULLIN; Cullin
    smart00647
    Location:17191781
    IBR; In Between Ring fingers
    pfam01485
    Location:18121850
    IBR; IBR domain, a half RING-finger domain
    pfam16195
    Location:122167
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:696826
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:14421522
    Cullin_Nedd8; Cullin protein neddylation domain
  10. XM_011514429.1XP_011512731.1  cullin-9 isoform X8

    Conserved Domains (5) summary
    smart00182
    Location:9101081
    CULLIN; Cullin
    smart00647
    Location:14581520
    IBR; In Between Ring fingers
    pfam01485
    Location:15511589
    IBR; IBR domain, a half RING-finger domain
    cl02148
    Location:435565
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:11811261
    Cullin_Nedd8; Cullin protein neddylation domain
  11. XM_017010590.1XP_016866079.1  cullin-9 isoform X6

RNA

  1. XR_002956271.1 RNA Sequence

  2. XR_001743278.2 RNA Sequence

    Related
    ENST00000515773.5
  3. XR_926123.1 RNA Sequence

  4. XR_001743281.1 RNA Sequence

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