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CUL9 cullin 9 [ Homo sapiens (human) ]

Gene ID: 23113, updated on 6-Sep-2022

Summary

Official Symbol
CUL9provided by HGNC
Official Full Name
cullin 9provided by HGNC
Primary source
HGNC:HGNC:15982
See related
Ensembl:ENSG00000112659 MIM:607489; AllianceGenome:HGNC:15982
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PARC; H7AP1
Summary
Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and ubiquitin protein ligase binding activity. Involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Located in cytosol. Part of cullin-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 6.1), skin (RPKM 5.9) and 25 other tissues See more
Orthologs
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Genomic context

See CUL9 in Genome Data Viewer
Location:
6p21.1
Exon count:
43
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43182196..43224587)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43010969..43053382)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43149934..43192325)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene serum response factor Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene tau tubulin kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686G1042, DKFZp686P2024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity TAS
Traceable Author Statement
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination TAS
Traceable Author Statement
more info
 
involved_in regulation of mitotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cullin-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cullin-9
Names
CUL-9
UbcH7-associated protein 1
p53-associated parkin-like cytoplasmic protein
parkin-like cytoplasmic p53 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015089.4NP_055904.1  cullin-9

    See identical proteins and their annotated locations for NP_055904.1

    Status: VALIDATED

    Source sequence(s)
    AJ318215, AL133375, BC002879, KF458162
    Consensus CDS
    CCDS4890.1
    UniProtKB/Swiss-Prot
    Q8IWT3, Q9BU56
    Related
    ENSP00000252050.4, ENST00000252050.9
    Conserved Domains (8) summary
    smart00182
    Location:15931764
    CULLIN; Cullin
    smart00647
    Location:21412203
    IBR; In Between Ring fingers
    pfam01485
    Location:22342272
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:20682117
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:18641944
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43182196..43224587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017010589.2XP_016866078.1  cullin-9 isoform X1

    Conserved Domains (8) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    smart00647
    Location:21902252
    IBR; In Between Ring fingers
    pfam01485
    Location:22832321
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:21172166
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:19131993
    Cullin_Nedd8; Cullin protein neddylation domain
  2. XM_011514423.3XP_011512725.1  cullin-9 isoform X1

    See identical proteins and their annotated locations for XP_011512725.1

    Conserved Domains (8) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    smart00647
    Location:21902252
    IBR; In Between Ring fingers
    pfam01485
    Location:22832321
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:21172166
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:19131993
    Cullin_Nedd8; Cullin protein neddylation domain
  3. XM_047418475.1XP_047274431.1  cullin-9 isoform X3

    UniProtKB/Swiss-Prot
    Q9BU56
  4. XM_047418478.1XP_047274434.1  cullin-9 isoform X6

  5. XM_011514422.2XP_011512724.1  cullin-9 isoform X1

    See identical proteins and their annotated locations for XP_011512724.1

    Conserved Domains (8) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    smart00647
    Location:21902252
    IBR; In Between Ring fingers
    pfam01485
    Location:22832321
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:21172166
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:19131993
    Cullin_Nedd8; Cullin protein neddylation domain
  6. XM_011514424.2XP_011512726.1  cullin-9 isoform X2

    Conserved Domains (8) summary
    smart00182
    Location:16151786
    CULLIN; Cullin
    smart00647
    Location:21632225
    IBR; In Between Ring fingers
    pfam01485
    Location:22562294
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:20902139
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11401270
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:18861966
    Cullin_Nedd8; Cullin protein neddylation domain
  7. XM_047418476.1XP_047274432.1  cullin-9 isoform X4

  8. XM_011514425.2XP_011512727.1  cullin-9 isoform X5

    Conserved Domains (8) summary
    smart00182
    Location:15321703
    CULLIN; Cullin
    smart00647
    Location:20802142
    IBR; In Between Ring fingers
    pfam01485
    Location:21732211
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366419
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:20072056
    zf-RING_2; Ring finger domain
    pfam16195
    Location:483528
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:10571187
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:18031883
    Cullin_Nedd8; Cullin protein neddylation domain
  9. XM_047418479.1XP_047274435.1  cullin-9 isoform X7

  10. XM_047418477.1XP_047274433.1  cullin-9 isoform X6

  11. XM_047418480.1XP_047274436.1  cullin-9 isoform X9

  12. XM_011514426.2XP_011512728.1  cullin-9 isoform X8

    Conserved Domains (8) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    smart00647
    Location:21902252
    IBR; In Between Ring fingers
    pfam01485
    Location:22832321
    IBR; IBR domain, a half RING-finger domain
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam13639
    Location:21172166
    zf-RING_2; Ring finger domain
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:19131993
    Cullin_Nedd8; Cullin protein neddylation domain
  13. XM_047418481.1XP_047274437.1  cullin-9 isoform X11

  14. XM_011514428.2XP_011512730.1  cullin-9 isoform X13

    Conserved Domains (4) summary
    smart00182
    Location:16421813
    CULLIN; Cullin
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  15. XM_047418482.1XP_047274438.1  cullin-9 isoform X14

  16. XM_011514430.2XP_011512732.1  cullin-9 isoform X15

    Conserved Domains (3) summary
    pfam11515
    Location:366440
    Cul7; Mouse development and cellular proliferation protein Cullin-7
    pfam16195
    Location:593638
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:11671297
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
  17. XM_047418483.1XP_047274439.1  cullin-9 isoform X15

  18. XM_011514427.1XP_011512729.1  cullin-9 isoform X10

    Conserved Domains (6) summary
    smart00182
    Location:11711342
    CULLIN; Cullin
    smart00647
    Location:17191781
    IBR; In Between Ring fingers
    pfam01485
    Location:18121850
    IBR; IBR domain, a half RING-finger domain
    pfam16195
    Location:122167
    UBA2_C; SUMO-activating enzyme subunit 2 C-terminus
    cl02148
    Location:696826
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    cl11186
    Location:14421522
    Cullin_Nedd8; Cullin protein neddylation domain
  19. XM_017010590.1XP_016866079.1  cullin-9 isoform X12

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    43010969..43053382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)