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kremen2 kringle containing transmembrane protein 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 780393, updated on 17-Aug-2024

Summary

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Official Symbol
kremen2provided by Xenbase
Official Full Name
kringle containing transmembrane protein 2provided by Xenbase
Primary source
Xenbase:XB-GENE-855741
See related
Ensembl:ENSXETG00000018365
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
krm2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
11
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 9 NC_030685.2 (12646993..12661033)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 9 NC_030685.1 (7094457..7105303)

Chromosome 9 - NC_030685.2Genomic Context describing neighboring genes Neighboring gene claudin 6, gene 2 Neighboring gene uncharacterized LOC116407636 Neighboring gene pelota homolog Neighboring gene progestin and adipoQ receptor family member IV Neighboring gene protein kinase, membrane associated tyrosine/threonine 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling. Hassler C, et al. Development, 2007 Dec. PMID 17978005
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kremen2 knockdown specifically reduces lipoprotein receptor-related protein 6 level in neurl crest explants.
    Title: Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC147633

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kremen protein 2
Names
kremen 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079463.1 → NP_001072931.1  kremen protein 2 precursor

    See identical proteins and their annotated locations for NP_001072931.1

    Status: PROVISIONAL

    Source sequence(s)
    BC124059
    UniProtKB/TrEMBL
    Q08CW3
    Conserved Domains (2) summary
    smart00130
    Location:23 → 106
    KR; Kringle domain
    cl02568
    Location:111 → 151
    WSC; WSC domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030685.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    12646993..12661033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031892759.1 → XP_031748619.1  kremen protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A803JY53
    Related
    ENSXETP00000110071.1, ENSXETT00000105956.1
    Conserved Domains (3) summary
    smart00130
    Location:27 → 110
    KR; Kringle domain
    cd00041
    Location:210 → 315
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam01822
    Location:116 → 196
    WSC; WSC domain

  2. XM_031892758.1 → XP_031748618.1  kremen protein 2 isoform X1

    UniProtKB/TrEMBL
    F6V5Z7
    Related
    ENSXETP00000039786.4, ENSXETT00000039786.4
    Conserved Domains (3) summary
    smart00130
    Location:27 → 110
    KR; Kringle domain
    cd00041
    Location:210 → 315
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam01822
    Location:116 → 196
    WSC; WSC domain

  3. XM_031892760.1 → XP_031748620.1  kremen protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8J1IV42
    Conserved Domains (3) summary
    cd00041
    Location:150 → 255
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    pfam01822
    Location:56 → 136
    WSC; WSC domain
    cl00100
    Location:12 → 50
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
Nucleotide Protein Strain
Heading Accession and Version

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