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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001253725.2 → NP_001240654.1 kremen protein 2 isoform e precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (5) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform d.
- Source sequence(s)
-
AC004235, AK075033, AK223422
- Consensus CDS
-
CCDS58413.1
- UniProtKB/TrEMBL
-
Q53F67
- Related
- ENSP00000459878.1, ENST00000575885.5
- Conserved Domains (3) summary
-
- smart00130
Location:34 → 119
- KR; Kringle domain
- cd00041
Location:180 → 285
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cl02568
Location:124 → 165
- WSC; WSC domain
-
NM_001253726.2 → NP_001240655.1 kremen protein 2 isoform f precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform f), compared to isoform d.
- Source sequence(s)
-
AK301953, BC003533
- Consensus CDS
-
CCDS58412.1
- UniProtKB/TrEMBL
-
Q53F67
- Related
- ENSP00000461860.1, ENST00000571007.5
- Conserved Domains (3) summary
-
- cd00041
Location:180 → 285
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00108
Location:35 → 119
- KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
- cl02568
Location:124 → 165
- WSC; WSC domain
-
NM_024507.4 → NP_078783.1 kremen protein 2 isoform b precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (2), also called kremen2b, lacks an exon in the 3' coding region compared to variant 4, resulting in a frameshift. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform d.
- Source sequence(s)
-
BC003533, BC009383
- Consensus CDS
-
CCDS10484.1
- UniProtKB/TrEMBL
-
Q53F67
- Related
- ENSP00000322079.6, ENST00000319500.11
- Conserved Domains (3) summary
-
- smart00130
Location:34 → 119
- KR; Kringle domain
- cd00041
Location:219 → 324
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- pfam01822
Location:124 → 205
- WSC; WSC domain
-
NM_172229.3 → NP_757384.1 kremen protein 2 isoform d precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
- Source sequence(s)
-
AB086405, BC003533, BC009383
- Consensus CDS
-
CCDS10483.1
- UniProtKB/Swiss-Prot
- B4DXF6, I3L2S2, Q8N2J4, Q8NCW0, Q8NCW1, Q96GL8, Q9BTP9
- UniProtKB/TrEMBL
-
Q53F67
- Related
- ENSP00000304422.5, ENST00000303746.10
- Conserved Domains (3) summary
-
- cd00041
Location:219 → 324
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00108
Location:35 → 119
- KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
- pfam01822
Location:124 → 205
- WSC; WSC domain
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCh38.p14 Primary Assembly
Genomic
-
NC_000016.10 Reference GRCh38.p14 Primary Assembly
- Range
-
2964275..2968380
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate T2T-CHM13v2.0
Genomic
-
NC_060940.1 Alternate T2T-CHM13v2.0
- Range
-
2990954..2995059
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the
cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related
sequence links, or BLAST links (BLink), but may still be retrieved by clicking on
their accession.version below.
-
NM_145347.1: Suppressed sequence
- Description
- NM_145347.1: This RefSeq was temporarily suppressed because currently there is insufficient data to support this transcript.
-
NM_145348.1: Suppressed sequence
- Description
- NM_145348.1: This RefSeq was temporarily suppressed because currently there is insufficient data to support this transcript.