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DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 780, updated on 9-Sep-2018

Summary

Official Symbol
DDR1provided by HGNC
Official Full Name
discoidin domain receptor tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:2730
See related
Ensembl:ENSG00000204580 MIM:600408; Vega:OTTHUMG00000031236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
Summary
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in brain (RPKM 49.5), thyroid (RPKM 24.8) and 22 other tissues See more
Orthologs

Genomic context

See DDR1 in Genome Data Viewer
Location:
6p21.33
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (30880958..30900156)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30850694..30867933)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2570 Neighboring gene RNA, 7SK small nuclear pseudogene 186 Neighboring gene microRNA 4640 Neighboring gene general transcription factor IIH subunit 4 Neighboring gene valyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
NHGRI GWA Catalog
Genetic predictors of medically refractory ulcerative colitis.
NHGRI GWA Catalog
Seven new loci associated with age-related macular degeneration.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
collagen binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase collagen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase collagen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
axon development IEA
Inferred from Electronic Annotation
more info
 
branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
ear development IEA
Inferred from Electronic Annotation
more info
 
embryo implantation IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
wound healing, spreading of cells IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
epithelial discoidin domain-containing receptor 1
Names
CD167 antigen-like family member A
PTK3A protein tyrosine kinase 3A
cell adhesion kinase
mammary carcinoma kinase 10
neuroepithelial tyrosine kinase
neurotrophic tyrosine kinase, receptor, type 4
protein-tyrosine kinase RTK-6
tyrosine kinase DDR
tyrosine-protein kinase CAK
NP_001189450.1
NP_001189451.1
NP_001189452.1
NP_001284581.1
NP_001284582.1
NP_001284583.1
NP_001945.3
NP_054699.2
NP_054700.2
XP_006715248.1
XP_011513184.1
XP_011513185.1
XP_011513186.1
XP_011513187.1
XP_011513188.1
XP_011513189.1
XP_011513190.1
XP_016866757.1
XP_016866758.1
XP_024302308.1
XP_024302309.1
XP_024302310.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029066.1 RefSeqGene

    Range
    5001..21073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202521.1NP_001189450.1  epithelial discoidin domain-containing receptor 1 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is missing an internal coding exon compared to variant 1. This results in a frame-shift, and early translation termination, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, the encoded isoform (4, also known as DDR1d) is represented as it has been detected in vivo in several colon carcinoma cell lines (PMID:11344127). This isoform is truncated and lacks the catalytic tyrosine kinase domain, therefore, most likely lacks intrinsic tyrosine kinase activity. It may function in some other regulatory capacity.
    Source sequence(s)
    AF353182, BC008716, L20817
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    Q96T62
    Conserved Domains (2) summary
    smart00231
    Location:30185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. NM_001202522.1NP_001189451.1  epithelial discoidin domain-containing receptor 1 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is missing an internal coding exon, and uses an alternate acceptor splice site at one of the coding exons compared to variant 1. This results in localized frame-shift, and a shorter isoform (5, also known as DDR1e) compared to isoform 1. This isoform lacks the ATP binding site, therefore, most likely lacks intrinsic tyrosine kinase activity. It may function in some other regulatory capacity.
    Source sequence(s)
    AF353183, BC008716, L20817
    Consensus CDS
    CCDS75419.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A0A0MSX3, Q96T61
    Related
    ENSP00000405998.2, ENST00000446312.5
    Conserved Domains (2) summary
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:478761
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001202523.1NP_001189452.1  epithelial discoidin domain-containing receptor 1 isoform 6 precursor

    See identical proteins and their annotated locations for NP_001189452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame upstream start codon, and a longer isoform (6) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK294793, BC008716, DC369107
    Consensus CDS
    CCDS56411.1
    UniProtKB/Swiss-Prot
    Q08345
    Related
    ENSP00000422442.1, OTTHUMP00000222080, ENST00000508312.5, OTTHUMT00000369045
    Conserved Domains (2) summary
    cd05096
    Location:585888
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:78202
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. NM_001297652.1NP_001284581.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001284581.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. It encodes isoform 1 (also known as DDR1a). Variants 1, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    AK291621, AK294793, BC008716, DA461082
    Consensus CDS
    CCDS4690.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCQ1
    Related
    ENSP00000407699.2, OTTHUMP00000164863, ENST00000418800.6, OTTHUMT00000257572
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  5. NM_001297653.1NP_001284582.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001284582.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. It encodes isoform 1 (also known as DDR1a). Variants 1, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    BC008716, L57508
    Consensus CDS
    CCDS4690.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCQ1
    Related
    ENSP00000365753.3, OTTHUMP00000029344, ENST00000376569.7, OTTHUMT00000076491
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  6. NM_001297654.1NP_001284583.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001284583.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an additional in-frame coding exon and differs in the 5' UTR compared to variant 1, resulting in a longer isoform (2, also known as DDR1b) with a 37 aa protein segment not found in isoform 1. Variants 2 and 9 encode the same isoform (2).
    Source sequence(s)
    BC008716, L20817
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCL1
    Related
    ENSP00000365752.3, OTTHUMP00000029345, ENST00000376568.7, OTTHUMT00000076492
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  7. NM_001954.4NP_001945.3  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001945.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1 (also known as DDR1a). Variants 1, 7, and 8 encode the same isoform (1).
    Source sequence(s)
    BC008716, BC070070
    Consensus CDS
    CCDS4690.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCQ1
    Related
    ENSP00000365754.4, ENST00000376570.8
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  8. NM_013993.2NP_054699.2  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_054699.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to variant 1, resulting in a longer isoform (2, also known as DDR1b) with a 37 aa protein segment not found in isoform 1. Variants 2 and 9 encode the same isoform (2).
    Source sequence(s)
    BC008716, CN362335, L11315
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCL1
    Related
    ENSP00000405039.1, ENST00000452441.5
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  9. NM_013994.2NP_054700.2  epithelial discoidin domain-containing receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_054700.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional in-frame coding exon, and uses an alternate in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in the longest isoform (3, also known as DDR1c) with additional protein segments not found in isoform 1.
    Source sequence(s)
    BC008716, BI193181, L11315, Z29093
    Consensus CDS
    CCDS47396.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCJ0
    Related
    ENSP00000427552.1, OTTHUMP00000164867, ENST00000513240.5, OTTHUMT00000257577
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    30880958..30900156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514887.2XP_011513189.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513189.1

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_017011269.2XP_016866758.1  epithelial discoidin domain-containing receptor 1 isoform X4

  3. XM_011514884.1XP_011513186.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513186.1

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. XM_011514886.2XP_011513188.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513188.1

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  5. XM_011514883.2XP_011513185.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513185.1

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  6. XM_024446542.1XP_024302310.1  epithelial discoidin domain-containing receptor 1 isoform X5

    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  7. XM_024446541.1XP_024302309.1  epithelial discoidin domain-containing receptor 1 isoform X5

    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  8. XM_017011268.2XP_016866757.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  9. XM_024446540.1XP_024302308.1  epithelial discoidin domain-containing receptor 1 isoform X5

    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  10. XM_011514885.2XP_011513187.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513187.1

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  11. XM_011514882.2XP_011513184.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011513184.1

    Conserved Domains (4) summary
    cd05096
    Location:622931
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00221
    Location:628929
    STYKc; Protein kinase; unclassified specificity
    smart00231
    Location:48203
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:78202
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  12. XM_006715185.2XP_006715248.1  epithelial discoidin domain-containing receptor 1 isoform X2

    See identical proteins and their annotated locations for XP_006715248.1

    Conserved Domains (4) summary
    cd05096
    Location:622925
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00221
    Location:628923
    STYKc; Protein kinase; unclassified specificity
    smart00231
    Location:48203
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:78202
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  13. XM_011514888.3XP_011513190.1  epithelial discoidin domain-containing receptor 1 isoform X3

    See identical proteins and their annotated locations for XP_011513190.1

    Conserved Domains (4) summary
    cd05096
    Location:585894
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    smart00221
    Location:591892
    STYKc; Protein kinase; unclassified specificity
    smart00231
    Location:48203
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:78202
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    2214565..2218962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p12 ALT_REF_LOCI_2

    Range
    2362382..2379927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p12 ALT_REF_LOCI_3

    Range
    2138908..2156466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p12 ALT_REF_LOCI_4

    Range
    2192855..2210394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p12 ALT_REF_LOCI_5

    Range
    2226762..2249066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p12 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p12 ALT_REF_LOCI_6

    Range
    2137781..2155326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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