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DDR1 discoidin domain receptor tyrosine kinase 1 [ Homo sapiens (human) ]

Gene ID: 780, updated on 25-Sep-2022

Summary

Official Symbol
DDR1provided by HGNC
Official Full Name
discoidin domain receptor tyrosine kinase 1provided by HGNC
Primary source
HGNC:HGNC:2730
See related
Ensembl:ENSG00000204580 MIM:600408; AllianceGenome:HGNC:2730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
Summary
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in brain (RPKM 49.5), thyroid (RPKM 24.8) and 22 other tissues See more
Orthologs
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Genomic context

See DDR1 in Genome Data Viewer
Location:
6p21.33
Exon count:
27
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (30880970..30900156)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (30745627..30764828)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (30848747..30867933)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13207 Neighboring gene RN7SK pseudogene 186 Neighboring gene microRNA 4640 Neighboring gene general transcription factor IIH subunit 4 Neighboring gene valyl-tRNA synthetase 2, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Genetic predictors of medically refractory ulcerative colitis.
EBI GWAS Catalog
Seven new loci associated with age-related macular degeneration.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables collagen binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase collagen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine kinase collagen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in axon development IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion TAS
Traceable Author Statement
more info
PubMed 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen-activated tyrosine kinase receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ear development IEA
Inferred from Electronic Annotation
more info
 
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
 
involved_in lactation IEA
Inferred from Electronic Annotation
more info
 
involved_in mammary gland alveolus development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
epithelial discoidin domain-containing receptor 1
Names
CD167 antigen-like family member A
PTK3A protein tyrosine kinase 3A
cell adhesion kinase
mammary carcinoma kinase 10
neuroepithelial tyrosine kinase
neurotrophic tyrosine kinase, receptor, type 4
protein-tyrosine kinase RTK-6
tyrosine kinase DDR
tyrosine-protein kinase CAK
NP_001189450.1
NP_001189451.1
NP_001189452.2
NP_001284581.1
NP_001284582.1
NP_001284583.1
NP_001374821.1
NP_001374822.1
NP_001374823.1
NP_001374824.1
NP_001374825.1
NP_001374826.1
NP_001374827.1
NP_001374828.1
NP_001374829.1
NP_001374830.1
NP_001374831.1
NP_001374832.1
NP_001374833.1
NP_001374834.1
NP_001374835.1
NP_001374836.1
NP_001374837.1
NP_001374838.1
NP_001374839.1
NP_001374840.1
NP_001374841.1
NP_001374842.1
NP_001374843.1
NP_001374844.1
NP_001374845.1
NP_001374846.1
NP_001374847.1
NP_001945.3
NP_054699.2
NP_054700.2
XP_011513186.1
XP_011513189.1
XP_016866757.1
XP_024302308.1
XP_024302309.1
XP_047275274.1
XP_047275275.1
XP_047275276.1
XP_047275277.1
XP_047275278.1
XP_047275279.1
XP_047275280.1
XP_047275281.1
XP_047275282.1
XP_047275283.1
XP_047275284.1
XP_047275285.1
XP_047275286.1
XP_047275287.1
XP_047275288.1
XP_047275289.1
XP_047275290.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029066.1 RefSeqGene

    Range
    5436..21073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202521.1NP_001189450.1  epithelial discoidin domain-containing receptor 1 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AF353182, BC008716, L20817
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    Q96T62
    Conserved Domains (2) summary
    smart00231
    Location:30185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. NM_001202522.1NP_001189451.1  epithelial discoidin domain-containing receptor 1 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AF353183, BC008716, L20817
    Consensus CDS
    CCDS75419.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A0A0MSX3, Q96T61
    Related
    ENSP00000405998.2, ENST00000446312.5
    Conserved Domains (2) summary
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:478761
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001202523.3NP_001189452.2  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS56411.1
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. NM_001297652.2NP_001284581.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001284581.1

    Status: REVIEWED

    Source sequence(s)
    AK291621, AK294793, BC008716, DA461082
    Consensus CDS
    CCDS4690.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCQ1
    Related
    ENSP00000407699.2, ENST00000418800.6
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  5. NM_001297653.2NP_001284582.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001284582.1

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS4690.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  6. NM_001297654.2NP_001284583.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001284583.1

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    Q08345, Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Related
    ENSP00000365752.3, ENST00000376568.8
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  7. NM_001387892.1NP_001374821.1  epithelial discoidin domain-containing receptor 1 isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCJ0
    Related
    ENSP00000427552.1, ENST00000513240.5
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  8. NM_001387893.1NP_001374822.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  9. NM_001387894.1NP_001374823.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  10. NM_001387895.1NP_001374824.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  11. NM_001387896.1NP_001374825.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  12. NM_001387897.1NP_001374826.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  13. NM_001387898.1NP_001374827.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  14. NM_001387899.1NP_001374828.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  15. NM_001387900.1NP_001374829.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  16. NM_001387901.1NP_001374830.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  17. NM_001387902.1NP_001374831.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  18. NM_001387903.1NP_001374832.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  19. NM_001387904.1NP_001374833.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/Swiss-Prot
    Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  20. NM_001387905.1NP_001374834.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Conserved Domains (2) summary
    cd05096
    Location:567876
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  21. NM_001387906.1NP_001374835.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Conserved Domains (2) summary
    cd05096
    Location:567876
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  22. NM_001387907.1NP_001374836.1  epithelial discoidin domain-containing receptor 1 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Conserved Domains (2) summary
    cd05096
    Location:567876
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  23. NM_001387908.1NP_001374837.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  24. NM_001387909.1NP_001374838.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  25. NM_001387910.1NP_001374839.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  26. NM_001387911.1NP_001374840.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  27. NM_001387912.1NP_001374841.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  28. NM_001387913.1NP_001374842.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  29. NM_001387914.1NP_001374843.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Related
    ENSP00000365753.3, ENST00000376569.7
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  30. NM_001387915.1NP_001374844.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  31. NM_001387916.1NP_001374845.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  32. NM_001387917.1NP_001374846.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  33. NM_001387918.1NP_001374847.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
    UniProtKB/TrEMBL
    A0A024RCQ1
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  34. NM_001410869.1NP_001397798.1  epithelial discoidin domain-containing receptor 1 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AL662870
  35. NM_001954.5NP_001945.3  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001945.3

    Status: REVIEWED

    Source sequence(s)
    BC008716, BC070070
    Consensus CDS
    CCDS4690.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCQ1
    Related
    ENSP00000365754.4, ENST00000376570.8
    Conserved Domains (2) summary
    cd05096
    Location:567870
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  36. NM_013993.3NP_054699.2  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_054699.2

    Status: REVIEWED

    Source sequence(s)
    AL662870, BC008716, CN362335, L11315
    Consensus CDS
    CCDS34385.1
    UniProtKB/Swiss-Prot
    Q08345, Q9UDL2
    UniProtKB/TrEMBL
    A0A024RCL1
    Related
    ENSP00000405039.1, ENST00000452441.5
    Conserved Domains (2) summary
    cd05096
    Location:604907
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  37. NM_013994.3NP_054700.2  epithelial discoidin domain-containing receptor 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_054700.2

    Status: REVIEWED

    Source sequence(s)
    AL662870
    Consensus CDS
    CCDS47396.1
    UniProtKB/Swiss-Prot
    Q08345
    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    30880970..30900156
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419324.1XP_047275280.1  epithelial discoidin domain-containing receptor 1 isoform X1

  2. XM_011514884.2XP_011513186.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513186.1

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_011514887.3XP_011513189.1  epithelial discoidin domain-containing receptor 1 isoform X5

    See identical proteins and their annotated locations for XP_011513189.1

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  4. XM_047419329.1XP_047275285.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A024RCJ0
  5. XM_047419318.1XP_047275274.1  epithelial discoidin domain-containing receptor 1 isoform X1

  6. XM_024446541.2XP_024302309.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  7. XM_047419321.1XP_047275277.1  epithelial discoidin domain-containing receptor 1 isoform X1

  8. XM_047419322.1XP_047275278.1  epithelial discoidin domain-containing receptor 1 isoform X1

  9. XM_047419320.1XP_047275276.1  epithelial discoidin domain-containing receptor 1 isoform X1

  10. XM_047419319.1XP_047275275.1  epithelial discoidin domain-containing receptor 1 isoform X1

  11. XM_047419326.1XP_047275282.1  epithelial discoidin domain-containing receptor 1 isoform X2

  12. XM_047419333.1XP_047275289.1  epithelial discoidin domain-containing receptor 1 isoform X4

  13. XM_017011268.3XP_016866757.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  14. XM_047419323.1XP_047275279.1  epithelial discoidin domain-containing receptor 1 isoform X1

  15. XM_047419330.1XP_047275286.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A024RCJ0
  16. XM_047419328.1XP_047275284.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A024RCJ0
  17. XM_047419325.1XP_047275281.1  epithelial discoidin domain-containing receptor 1 isoform X2

  18. XM_047419331.1XP_047275287.1  epithelial discoidin domain-containing receptor 1 isoform X3

  19. XM_047419332.1XP_047275288.1  epithelial discoidin domain-containing receptor 1 isoform X4

  20. XM_024446540.2XP_024302308.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A024RCJ0
    Conserved Domains (2) summary
    cd05096
    Location:604913
    PTKc_DDR1; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1
    cd00057
    Location:60184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  21. XM_047419327.1XP_047275283.1  epithelial discoidin domain-containing receptor 1 isoform X5

    UniProtKB/TrEMBL
    A0A024RCJ0
  22. XM_047419334.1XP_047275290.1  epithelial discoidin domain-containing receptor 1 isoform X4

    Related
    ENSP00000422442.1, ENST00000508312.5

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_167244.2 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    2214565..2218962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    2360739..2379927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

    Range
    2137265..2156466
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_4

Genomic

  1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

    Range
    2191212..2210394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

    Range
    2225119..2249066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

    Range
    2136138..2155326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    30745627..30764828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)