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Ddr1 discoidin domain receptor family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 12305, updated on 9-May-2024

Summary

Official Symbol
Ddr1provided by MGI
Official Full Name
discoidin domain receptor family, member 1provided by MGI
Primary source
MGI:MGI:99216
See related
Ensembl:ENSMUSG00000003534 AllianceGenome:MGI:99216
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cak; Nep; PTK3A; CD167a; 6030432F18
Summary
Enables collagen binding activity. Involved in several processes, including smooth muscle cell migration; smooth muscle cell-matrix adhesion; and wound healing, spreading of cells. Acts upstream of or within several processes, including collagen-activated tyrosine kinase receptor signaling pathway; mammary gland development; and neuron projection development. Located in plasma membrane. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; mammary gland; and retina. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human DDR1 (discoidin domain receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 32.9), colon adult (RPKM 31.1) and 24 other tissues See more
Orthologs
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Genomic context

See Ddr1 in Genome Data Viewer
Location:
17 B1; 17 18.7 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35992459..36015633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35681567..35704741, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7529 Neighboring gene valyl-tRNA synthetase 2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35808865-35809171 Neighboring gene STARR-positive B cell enhancer ABC_E7530 Neighboring gene general transcription factor II H, polypeptide 4 Neighboring gene STARR-seq mESC enhancer starr_42470 Neighboring gene STARR-seq mESC enhancer starr_42472 Neighboring gene predicted gene, 23864 Neighboring gene predicted gene 4577 Neighboring gene VISTA enhancer mm90 Neighboring gene STARR-positive B cell enhancer mm9_chr17:35874761-35875062 Neighboring gene predicted gene 20443 Neighboring gene RIKEN cDNA 4833427F10 gene Neighboring gene predicted gene, 32409

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
enables collagen binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase collagen receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine kinase collagen receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within axon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in collagen-activated tyrosine kinase receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in collagen-activated tyrosine kinase receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within female pregnancy IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lactation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of extracellular matrix disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in smooth muscle cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth muscle cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing, spreading of cells ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
epithelial discoidin domain-containing receptor 1
Names
CD167 antigen-like family member A
cell adhesion kinase
discoidin receptor tyrosine kinase
epithelial discoidin domain receptor 1
protein-tyrosine kinase MPK-6
tyrosine kinase DDR
tyrosine-protein kinase CAK
NP_001185760.1
NP_001185762.1
NP_001411562.1
NP_001411564.1
NP_001411566.1
NP_001411568.1
NP_001411569.1
NP_001411570.1
NP_031610.1
NP_766550.1
XP_006523598.1
XP_006523599.1
XP_006523600.1
XP_011244561.1
XP_030105324.1
XP_036016169.1
XP_036016171.1
XP_036016172.1
XP_036016173.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198831.1NP_001185760.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185760.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, CK790776, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Related
    ENSMUSP00000133047.3, ENSMUST00000166980.9
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001198833.1NP_001185762.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, BY062785, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Related
    ENSMUSP00000113062.2, ENSMUST00000119825.8
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001424633.1NP_001411562.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/Swiss-Prot
    Q03146
  4. NM_001424635.1NP_001411564.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/Swiss-Prot
    Q03146
  5. NM_001424637.1NP_001411566.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/TrEMBL
    Q544T2
  6. NM_001424639.1NP_001411568.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/TrEMBL
    Q544T2
  7. NM_001424640.1NP_001411569.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/TrEMBL
    Q544T2
  8. NM_001424641.1NP_001411570.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    CR974483
    UniProtKB/TrEMBL
    Q544T2
  9. NM_007584.3NP_031610.1  epithelial discoidin domain-containing receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AK143088, BC037108, L57509
    Consensus CDS
    CCDS28703.1
    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Related
    ENSMUSP00000112570.2, ENSMUST00000117301.8
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  10. NM_172962.2NP_766550.1  epithelial discoidin domain-containing receptor 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_766550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (2) than isoform 1.
    Source sequence(s)
    CR974483
    Consensus CDS
    CCDS37603.1
    UniProtKB/TrEMBL
    O35407, Q544T2
    Related
    ENSMUSP00000094945.4, ENSMUST00000097333.10
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35992459..36015633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523536.4XP_006523599.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006523599.1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  2. XM_030249464.2XP_030105324.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    O35407, Q544T2
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006523537.3XP_006523600.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006523600.1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  4. XM_036160276.1XP_036016169.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    O35407, Q544T2
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006523535.5XP_006523598.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_006523598.1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  6. XM_036160280.1XP_036016173.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    O35407, Q544T2
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  7. XM_036160279.1XP_036016172.1  epithelial discoidin domain-containing receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain
  8. XM_036160278.1XP_036016171.1  epithelial discoidin domain-containing receptor 1 isoform X2

    UniProtKB/TrEMBL
    O35407, Q544T2
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:565868
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011246259.3XP_011244561.1  epithelial discoidin domain-containing receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_011244561.1

    UniProtKB/Swiss-Prot
    Q03146
    UniProtKB/TrEMBL
    O35407
    Conserved Domains (2) summary
    cd00057
    Location:58185
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21453
    Location:602905
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001782030.3 RNA Sequence

  2. XR_004939465.1 RNA Sequence

  3. XR_004939464.1 RNA Sequence

    Related
    ENSMUST00000155957.8