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Ube2s ubiquitin-conjugating enzyme E2S [ Mus musculus (house mouse) ]

Gene ID: 77891, updated on 7-Apr-2024

Summary

Official Symbol
Ube2sprovided by MGI
Official Full Name
ubiquitin-conjugating enzyme E2Sprovided by MGI
Primary source
MGI:MGI:1925141
See related
Ensembl:ENSMUSG00000060860 AllianceGenome:MGI:1925141
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E2-EPF; 0910001J09Rik; 6720465F12Rik
Summary
Predicted to enable anaphase-promoting complex binding activity and ubiquitin conjugating enzyme activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; free ubiquitin chain polymerization; and protein polyubiquitination. Predicted to act upstream of or within protein K11-linked ubiquitination. Predicted to be part of anaphase-promoting complex. Predicted to be active in nucleus. Orthologous to human UBE2S (ubiquitin conjugating enzyme E2 S). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 313.9), thymus adult (RPKM 179.6) and 27 other tissues See more
Orthologs
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Genomic context

Location:
7 A1; 7 2.78 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4811013..4815339, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4808014..4812340, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 238 Neighboring gene STARR-positive B cell enhancer ABC_E6507 Neighboring gene predicted gene, 57780 Neighboring gene ribosomal protein L28 Neighboring gene STARR-positive B cell enhancer ABC_E441 Neighboring gene STARR-seq mESC enhancer starr_17941 Neighboring gene shisa family member 7 Neighboring gene predicted gene, 36127 Neighboring gene isochorismatase domain containing 2b Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:4817662-4817771 Neighboring gene predicted gene, 53350

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC101982

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables anaphase-promoting complex binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in exit from mitosis ISO
Inferred from Sequence Orthology
more info
 
involved_in free ubiquitin chain polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K27-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K29-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K6-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 S
Names
E2 ubiquitin-conjugating enzyme S
E2-EPF5
ubiquitin carrier protein S
ubiquitin-conjugating enzyme E2-24 kDa
ubiquitin-conjugating enzyme E2-EPF5
ubiquitin-protein ligase S
NP_598538.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133777.2NP_598538.1  ubiquitin-conjugating enzyme E2 S

    See identical proteins and their annotated locations for NP_598538.1

    Status: PROVISIONAL

    Source sequence(s)
    AC162034
    Consensus CDS
    CCDS39743.1
    UniProtKB/Swiss-Prot
    Q3U4V7, Q8CF67, Q921J4
    UniProtKB/TrEMBL
    A0A6I8MX03
    Related
    ENSMUSP00000078459.8, ENSMUST00000079496.9
    Conserved Domains (1) summary
    pfam00179
    Location:16152
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    4811013..4815339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)