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UBE2S ubiquitin conjugating enzyme E2 S [ Homo sapiens (human) ]

Gene ID: 27338, updated on 19-Sep-2021

Summary

Official Symbol
UBE2Sprovided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 Sprovided by HGNC
Primary source
HGNC:HGNC:17895
See related
Ensembl:ENSG00000108106 MIM:610309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPF5; E2EPF; E2-EPF
Summary
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 34.2), bone marrow (RPKM 25.4) and 21 other tissues See more
Orthologs
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Genomic context

See UBE2S in Genome Data Viewer
Location:
19q13.42
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55399745..55408439, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55911113..55919156, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 238 Neighboring gene ribosomal protein L28 Neighboring gene microRNA 6805 Neighboring gene small nucleolar RNA, C/D box 157 Neighboring gene uncharacterized LOC105372462 Neighboring gene Sharpr-MPRA regulatory region 8373 Neighboring gene shisa family member 7 Neighboring gene isochorismatase domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables anaphase-promoting complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
involved_in exit from mitosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in free ubiquitin chain polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K27-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K29-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K6-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 S
Names
E2 ubiquitin-conjugating enzyme S
E2-EPF5
ubiquitin carrier protein S
ubiquitin conjugating enzyme E2S
ubiquitin-conjugating enzyme E2-24 kDa
ubiquitin-conjugating enzyme E2-EPF5
ubiquitin-protein ligase S
NP_055316.2
XP_011525054.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014501.3NP_055316.2  ubiquitin-conjugating enzyme E2 S

    See identical proteins and their annotated locations for NP_055316.2

    Status: REVIEWED

    Source sequence(s)
    AC020922, BC065364, CA421746, CN305224
    Consensus CDS
    CCDS33114.1
    UniProtKB/Swiss-Prot
    Q16763
    Related
    ENSP00000264552.8, ENST00000264552.14
    Conserved Domains (1) summary
    pfam00179
    Location:16152
    UQ_con; Ubiquitin-conjugating enzyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55399745..55408439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526752.2XP_011525054.1  ubiquitin-conjugating enzyme E2 S isoform X1

    Conserved Domains (1) summary
    pfam00179
    Location:16114
    UQ_con; Ubiquitin-conjugating enzyme
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