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Usp45 ubiquitin specific petidase 45 [ Mus musculus (house mouse) ]

Gene ID: 77593, updated on 12-May-2024

Summary

Official Symbol
Usp45provided by MGI
Official Full Name
ubiquitin specific petidase 45provided by MGI
Primary source
MGI:MGI:101850
See related
Ensembl:ENSMUSG00000040455 AllianceGenome:MGI:101850
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gcap7; 3110003C05Rik; 4930550B20Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Involved in photoreceptor cell maintenance. Predicted to be located in cytoplasm; nucleus; and photoreceptor inner segment. Human ortholog(s) of this gene implicated in Leber congenital amaurosis. Orthologous to human USP45 (ubiquitin specific peptidase 45). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 6.8), liver E14.5 (RPKM 5.5) and 27 other tissues See more
Orthologs
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Genomic context

See Usp45 in Genome Data Viewer
Location:
4 A3; 4 8.93 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (21767161..21837872)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (21767161..21837872)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 13 Neighboring gene STARR-seq mESC enhancer starr_09729 Neighboring gene STARR-seq mESC enhancer starr_09730 Neighboring gene cyclin C Neighboring gene STARR-positive B cell enhancer ABC_E3481 Neighboring gene STARR-seq mESC enhancer starr_09732 Neighboring gene STARR-seq mESC enhancer starr_09733 Neighboring gene thiosulfate sulfurtransferase (rhodanese)-like domain containing 3 Neighboring gene RIKEN cDNA 4930528A17 gene Neighboring gene STARR-seq mESC enhancer starr_09734 Neighboring gene PNN interacting serine/arginine-rich Neighboring gene coenzyme Q3 methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • RP23-38K18.3

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA repair ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein deubiquitination ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 45
Names
deubiquitinating enzyme 45
granule cell antiserum positive 7
ubiquitin specific protease 45
ubiquitin thioesterase 45
ubiquitin thiolesterase 45
ubiquitin-specific-processing protease 45
NP_001277354.1
NP_690038.1
XP_006538424.1
XP_006538425.1
XP_011248434.1
XP_030109769.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290425.1NP_001277354.1  ubiquitin carboxyl-terminal hydrolase 45 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AI465456, AK019756, AL772187, BB213271
    Consensus CDS
    CCDS71351.1
    UniProtKB/Swiss-Prot
    Q8K387
    Related
    ENSMUSP00000048324.6, ENSMUST00000040429.12
    Conserved Domains (3) summary
    cd02667
    Location:192762
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:192761
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:62132
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. NM_152825.2NP_690038.1  ubiquitin carboxyl-terminal hydrolase 45 isoform 1

    See identical proteins and their annotated locations for NP_690038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AI465456, AK019756, AK040660, AL772187, BM227454
    Consensus CDS
    CCDS38700.1
    UniProtKB/Swiss-Prot
    A2AJT1, Q8BU19, Q8BZ19, Q8K387
    Related
    ENSMUSP00000067109.9, ENSMUST00000065111.15
    Conserved Domains (3) summary
    COG5207
    Location:72359
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02667
    Location:587810
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:192388
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    21767161..21837872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250132.1XP_011248434.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X1

    See identical proteins and their annotated locations for XP_011248434.1

    UniProtKB/Swiss-Prot
    A2AJT1, Q8BU19, Q8BZ19, Q8K387
    Conserved Domains (3) summary
    COG5207
    Location:72359
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02667
    Location:587810
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:192388
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  2. XM_006538362.1XP_006538425.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X2

    Conserved Domains (3) summary
    COG5207
    Location:71358
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02667
    Location:586809
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:191387
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  3. XM_030253909.1XP_030109769.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X3

    Conserved Domains (3) summary
    COG5560
    Location:192713
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cl02553
    Location:192388
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:62132
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  4. XM_006538361.5XP_006538424.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X1

    See identical proteins and their annotated locations for XP_006538424.1

    UniProtKB/Swiss-Prot
    A2AJT1, Q8BU19, Q8BZ19, Q8K387
    Conserved Domains (3) summary
    COG5207
    Location:72359
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02667
    Location:587810
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:192388
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

  1. XR_004942010.1 RNA Sequence

    Related
    ENSMUST00000137293.8
  2. XR_004942011.1 RNA Sequence