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USP45 ubiquitin specific peptidase 45 [ Homo sapiens (human) ]

Gene ID: 85015, updated on 27-Jun-2020

Summary

Official Symbol
USP45provided by HGNC
Official Full Name
ubiquitin specific peptidase 45provided by HGNC
Primary source
HGNC:HGNC:20080
See related
Ensembl:ENSG00000123552 MIM:618439
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCA19
Summary
The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in gall bladder (RPKM 1.4), small intestine (RPKM 1.4) and 25 other tissues See more
Orthologs

Genomic context

See USP45 in Genome Data Viewer
Location:
6q16.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (99432306..99515770, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99880182..99963565, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene coenzyme Q3, methyltransferase Neighboring gene PNN interacting serine and arginine rich protein Neighboring gene uncharacterized LOC101927365 Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene cyclin C Neighboring gene ribosomal protein S3 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC14793

Gene Ontology Provided by GOA

Function Evidence Code Pubs
thiol-dependent ubiquitin-specific protease activity IDA
Inferred from Direct Assay
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
global genome nucleotide-excision repair TAS
Traceable Author Statement
more info
 
photoreceptor cell maintenance ISS
Inferred from Sequence or Structural Similarity
more info
 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 45
Names
deubiquitinating enzyme 45
ubiquitin specific protease 45
ubiquitin thioesterase 45
ubiquitin thiolesterase 45
ubiquitin-specific-processing protease 45
NP_001073950.1
NP_001332950.1
NP_001332951.1
NP_001332952.1
NP_001332953.1
NP_001332954.1
NP_001332955.1
NP_001332956.1
NP_001332957.1
NP_001332958.1
NP_001332959.1
NP_001332962.1
NP_116318.2
XP_005267227.1
XP_016866870.1
XP_016866871.1
XP_016866874.1
XP_016866875.1
XP_024302342.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080481.2NP_001073950.1  ubiquitin carboxyl-terminal hydrolase 45 isoform a

    See identical proteins and their annotated locations for NP_001073950.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-3 all encode the same isoform (a).
    Source sequence(s)
    AL137784, AL513550
    Consensus CDS
    CCDS34501.1
    UniProtKB/Swiss-Prot
    Q70EL2
    Related
    ENSP00000333376.6, ENST00000327681.10
    Conserved Domains (3) summary
    cd02667
    Location:603811
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:191387
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:62132
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. NM_001346021.2NP_001332950.1  ubiquitin carboxyl-terminal hydrolase 45 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1 and 3, encodes isoform a.
    Source sequence(s)
    AL137784, AL513550
    Consensus CDS
    CCDS34501.1
    UniProtKB/Swiss-Prot
    Q70EL2
  3. NM_001346022.3NP_001332951.1  ubiquitin carboxyl-terminal hydrolase 45 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
    Source sequence(s)
    AL137784, AL513550
    Consensus CDS
    CCDS34501.1
    UniProtKB/Swiss-Prot
    Q70EL2
    Related
    ENSP00000424372.1, ENST00000500704.6
  4. NM_001346023.2NP_001332952.1  ubiquitin carboxyl-terminal hydrolase 45 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
  5. NM_001346024.2NP_001332953.1  ubiquitin carboxyl-terminal hydrolase 45 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
  6. NM_001346025.2NP_001332954.1  ubiquitin carboxyl-terminal hydrolase 45 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
  7. NM_001346026.2NP_001332955.1  ubiquitin carboxyl-terminal hydrolase 45 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
  8. NM_001346027.2NP_001332956.1  ubiquitin carboxyl-terminal hydrolase 45 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 9 and 10, encodes isoform f.
    Source sequence(s)
    AL137784, AL513550
    Conserved Domains (1) summary
    cd02667
    Location:243451
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  9. NM_001346028.2NP_001332957.1  ubiquitin carboxyl-terminal hydrolase 45 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 8 and 10, encodes isoform f.
    Source sequence(s)
    AL137784, AL513550
    Conserved Domains (1) summary
    cd02667
    Location:243451
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  10. NM_001346029.2NP_001332958.1  ubiquitin carboxyl-terminal hydrolase 45 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 8 and 9, encodes isoform f.
    Source sequence(s)
    AL137784, AL513550
    Conserved Domains (1) summary
    cd02667
    Location:243451
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  11. NM_001346030.2NP_001332959.1  ubiquitin carboxyl-terminal hydrolase 45 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
  12. NM_001346033.1NP_001332962.1  ubiquitin carboxyl-terminal hydrolase 45 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 12, encodes isoform h.
    Source sequence(s)
    AL137784, AL513550
    Consensus CDS
    CCDS87419.1
    UniProtKB/TrEMBL
    D6RBV3
    Related
    ENSP00000423993.1, ENST00000472914.6
  13. NM_032929.2NP_116318.2  ubiquitin carboxyl-terminal hydrolase 45 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variant 13, encodes isoform h.
    Source sequence(s)
    AL137784, AL513550
    Consensus CDS
    CCDS87419.1
    UniProtKB/TrEMBL
    D6RBV3
    Related
    ENSP00000330540.5, ENST00000329966.10

RNA

  1. NR_144344.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
    Related
    ENST00000496518.6
  2. NR_144345.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
  3. NR_144346.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
  4. NR_144347.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550
  5. NR_144348.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL137784, AL513550

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    99432306..99515770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267170.4XP_005267227.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X1

    See identical proteins and their annotated locations for XP_005267227.1

    UniProtKB/Swiss-Prot
    Q70EL2
    Conserved Domains (3) summary
    cd02667
    Location:603811
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:191387
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam02148
    Location:62132
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein
  2. XM_024446574.1XP_024302342.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X3

    Conserved Domains (1) summary
    cd02667
    Location:243451
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  3. XM_017011382.1XP_016866871.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X3

    Conserved Domains (1) summary
    cd02667
    Location:243451
    Peptidase_C19K; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  4. XM_017011381.1XP_016866870.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X2

  5. XM_017011385.2XP_016866874.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X4

  6. XM_017011386.2XP_016866875.1  ubiquitin carboxyl-terminal hydrolase 45 isoform X5

RNA

  1. XR_001743700.2 RNA Sequence

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